Results 51 to 60 of about 33,494,515 (149)

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study [PDF]

, 2012
BACKGROUND: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Delta27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is ...
Reeder, J. C., Livingstone Tavul (46297), Danielle I. Stanisic (137910), Laman Moses, Peter Siba (112258), Dabod Elijah, Laman, M, Siba, P., Zimmerman, P. A., Senn, Nicolas, Davis, TME, Nicolas Senn, J. Robinson, Leanne, Patricia Rarau (137896), Leanne J. Robinson (137914), Rarau, Patricia, Pascal Michon, Robinson Leanne J., Dabod, Elijah, Tavul, L., Laurens Manning (112248), Livingstone Tavul, Grimberg, B. T., Manning, Laurens, Aponte, JJ, Elijah Dabod (137918), Reeder John C., Moses Laman, Michon, P., Robinson, LJ, Zimmerman Peter A., Aponte John J., Lin, E., Laman, M., I. Stanisic, Danielle, Ivo Mueller (46609), Dabod, E., Senn, N, Laurens Manning, Tavul, Livingstone, John J Aponte, Enmoore Lin, Davis Timothy M. E., Michon, P, Grimberg, BT, Mueller, Ivo, Siba, P, Tavul, L, Ivo Mueller, Senn, N., Enmoore Lin (137888), Lin, Enmoore, Manning, L., King Christopher L., Leanne J Robinson, Brian T. Grimberg (137907), Stanisic Danielle I., Pascal Michon (46294), John C Reeder, Timothy M. E. Davis (112260), Robinson, L. J., Christopher L. King (137930), Rarau, P., Dabod, E, Rosanas-Urgell, Anna, Reeder, JC, Rosanas-Urgell Anna, Rosanas-Urgell, A., Aponte, J. J., T. Grimberg, Brian, Stanisic, D. I., Michon, Pascal, Davis, T. M., Rarau Patricia, John C. Reeder (137922), Lin Enmoore, Senn Nicolas, C. Reeder, John, Peter A. Zimmerman (137926), Peter Siba, Zimmerman, PA, Siba, Peter, Mueller, I, Manning, L, Brian T Grimberg, Manning Laurens, L. King, Christopher, Michon Pascal, Siba Peter, Mueller Ivo, Christopher L King, Timothy M E Davis, M. E. Davis, Timothy, Moses Laman (112250), King, CL, Laman, Moses, J. Aponte, John, Grimberg Brian T., Tavul Livingstone, Danielle I Stanisic, Elijah Dabod, Stanisic, DI, Patricia Rarau, King, C. L., Anna Rosanas-Urgell, Lin, E, Mueller, I., John J. Aponte (89761), Nicolas Senn (137902), A. Zimmerman, Peter, Anna Rosanas-Urgell (112252), Rarau, P, Peter A Zimmerman, Rosanas-Urgell, A   +113 more
core   +1 more source

N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A series of extended aromatic compounds with tunable substituents was synthesized using a multistep methodology which allows various substitutions of the 8H‐quino[4,3,2‐kl]acridine scaffold. This chemical series appeared as a promising way to new antimalarial drug candidates with high activity (IC50 < 100 nM), exhibiting a novel mechanism of action ...
Steve Saulnier, Marco Antônio G. B. Gomes, Mariam Salim, Maxime Guichonnet, Michel Nguyen, Laure Vendier, Flore Nardella, Jean‐Michel Augereau, Dennis Gomez, Anne Robert, Françoise Benoit‐Vical   +10 more
wiley   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell [PDF]

, 2013
The malaria parasite exports proteins across its plasma membrane and a surrounding parasitophorous vacuole membrane, into its host erythrocyte. Most exported proteins contain a Host Targeting motif (HT motif) that targets them for export. In the parasite
Thalassinos, Konstantinos, Tarr, Sarah J., Osborne, Andrew R., Cryar, Adam, Haldar, K.   +4 more
core   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism‐Based Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Phenolic antioxidants in CHMs mainly include chalcone, stilbene, flavonoid, xanthone, and Diels–Alder‐type adducts. They undergo direct and indirect pathways to exert antioxidant action. The indirect pathway is transition metal‐chelating, while the direct pathway comprises several redox‐based reactions (e.g., SET and HAT) and RAF reactions.
Xican Li
wiley   +1 more source

An In Vitro and In Vivo Assessment of the Anti‐Breast Cancer Activity of Erythrina excelsa Baker (Fabaceae) Bark Extracts

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Breast cancer remains a topic of interest due to its high mortality rate among Cameroonian women. The barks of Erythrina excelsa are traditionally used for medicinal purposes in the management of various conditions including cancer.
Jonas Walantini, Marius Trésor Kemegne Sipping, Merline Nguedia Ymele, Roland Nhouma Rebe, Joël Abel Gbaweng Yaya, Derek Tantoh Ndinteh, Dieudonné Njamen, Stéphane Zingue   +7 more
wiley   +1 more source

Deep intronic ANK1 variants causing pseudo‐exon inclusion in hereditary spherocytosis: Whole‐genome sequencing and functional assessment

British Journal of Haematology, EarlyView.
Victor Marin, Alexandre Janin, Céline Renoux, Yoann Huguenin, AURAGEN consortium, Stéphanie Dulucq, Louis Lebreton, Philippe Joly, Julian Boutin   +8 more
wiley   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source