Results 261 to 270 of about 3,774,880 (304)

The Impact of Plasma Protein Binding on the Renal Transport of Organic Anions

The Journal of Pharmacology and Experimental Therapeutics, 2006
Drugs and xenobiotics bind to plasma proteins with varying degrees of affinity, and the amount of binding has a direct effect on free drug concentration and subsequent pharmacokinetics. Multiple active and facilitative transport systems regulate the excretion of anionic compounds from the blood in excretory and barrier tissues.
Daniel A J, Bow, Jennifer L, Perry, John D, Simon, John B, Pritchard   +3 more
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Fluorescent stilbene (BADS) binding proteins in anion-transporting epithelia

American Journal of Physiology-Cell Physiology, 1990
Chloride transport occurs at the interface between the internal and external environments of a cell where chloride uptake or efflux is regulated through a variety of mechanisms that involve cotransport of cations, exchange mechanism with anions, or movement through channels.
S F, Pearce, J A, Zadunaisky
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Anion transport in relation to proteolytic dissection of band 3 protein

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1978
Sulfate efflux was measured in inside-out vesicles obtained from human red cells. Inhibition was observed in vesicles derived from cells pretreated with DIDS (4,4'-diisothiocyano-2,2'-stilbene disulfonate) or after addition of dipyridamole to the vesicles, both agents being specific and potent inhibitors of anion transport in cells.
S, Grinstein, S, Ship, A, Rothstein
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Conformation and stability of the anion transport protein of human erythrocyte membranes

Biochemistry, 1985
The conformation and stability of purified preparations of band 3, the anion transport protein of human erythrocyte membranes, and its constituent proteolytic subfragments have been studied by circular dichroism. Band 3, purified in the presence of the nonionic detergent n-dodecyl octaethylene glycol monoether (C12E8), had an alpha-helical content of ...
K, Oikawa, D M, Lieberman, R A, Reithmeier   +2 more
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Denaturation of a membrane transport protein by urea: The erythrocyte anion exchanger

The Journal of Membrane Biology, 1987
Chloride equilibrium exchange was measured in the presence of intracellular and extracellular urea, several different alkylureas and thiourea. Urea half-inhibited Cl exchange at about 2.5 M, but the other, less polar analogs had significantly higher potencies; e.g., butylurea half-inhibited at about 60 mM.
O, Fröhlich, S C, Jones
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Transepithelial Transport of Organic Anions across the Choroid Plexus: Possible Involvement of Organic Anion Transporter and Multidrug Resistance-Associated Protein

The Journal of Pharmacology and Experimental Therapeutics, 1999
Transport characteristics of 17beta-estradiol 17beta-D-glucuronide (E217betaG), a dual substrate of the transporters for cellular uptake (organic anion-transporting polypeptide 1 or oatp1) and cellular excretion (multidrug resistance-associated protein 1or MRP1), in the rat choroid plexus were studied in vivo and in vitro.
J, Nishino, H, Suzuki, D, Sugiyama, T, Kitazawa, K, Ito, M, Hanano, Y, Sugiyama   +6 more
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Structure and Function of the Red Blood Cell Anion Transport Protein

Annual Review of Biophysics and Biophysical Chemistry, 1989
PHYSIOLOGICAL FUNCTION . Role of Chloride-Bicarbonate Exchange in Carbon Dioxide Transport .. Other Substrates of Red Cell Band 3 . . Transport Functions Other Than Anion Exchange . . Band 3 Homologs in Nonerythroid Cells ..
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Macromolecular conjugates of transport inhibitors: new tools for probing topography of anion transport proteins

American Journal of Physiology-Cell Physiology, 1991
Macromolecular-conjugated, water-soluble, membrane-impermeant compounds were designed and assessed as topological probes for chloride-transporting agencies. The novel compounds were derivatives of either disulfonic stilbene (DS) and benzylaminoethylsulfonate (BS), "classical" inhibitors of erythrocyte chloride-bicarbonate exchange, or of ...
O, Eidelman, P, Yani, H C, Englert, H G, Lang, R, Greger, Z I, Cabantchik   +5 more
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Asymmetry of functional sites of the erythrocyte anion transport protein

Trends in Biochemical Sciences, 1978
The accessibility of functional sites of the anion transport system of the red blood cell to inhibitory probes differs depending on the side of the membrane to which they are applied. These effects are discussed in terms of the asymmetric arrangement of the transport protein, Band 3, in the membrane.
A. Rothstein, S. Grinstein, S. Ship, P.A. Knauf   +3 more
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Immunologic distribution of an organic anion transport protein in rat liver and kidney

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1996
A Na(+)-independent organic anion transport protein was recently cloned from rat liver using a Xenopus laevis oocyte expression system [E. Jacquemin, B. Hagenbuch, B. Stieger, A.W. Wolkoff, and P.J. Meier, Proc. Natl. Acad. Sci. USA 91: 133-137, 1994].
Bergwerk, A. J., Shi, X., Ford, A. C., Kanai, N., Jacquemin, E., Burk, R. D., Bai, S., Novikoff, P. M., Stieger, B., Meier, P. J., Schuster, V. L., Wolkoff, A. W.   +11 more
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