Results 301 to 310 of about 373,177 (393)

Reactive Cysteines in Proteins are the Dominant Reductants for Platinum(IV) Prodrug Activation in Live Cells

Angewandte Chemie, EarlyView.
Pt‐Luc was developed as a pioneering bioluminescent reporter for real‐time monitoring of Pt(IV) reduction in live cells. Using this advanced reporter, we identified that reactive cysteines in proteins, rather than those in small molecules, predominantly mediate the reduction of Pt(IV) prodrugs.
Shu Chen, Wang Peng, Houzong Yao, Zhiqin Deng, Zhao Yue, Gongyuan Liu, Jiaqian Xu, Naixin Lin, Weikang Xu, Jianbo Yue, Guangyu Zhu   +10 more
wiley   +1 more source

Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects. [PDF]

Foods
Han Y, Liu W, Li K, Zhang M, Liu X, Li L, Guo Z, Li H.   +7 more
europepmc   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

Angewandte Chemie, EarlyView.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano, Rosa Márquez García, Wiktor Szymanski   +2 more
wiley   +1 more source

Integrating proteomics and metabolomics to elucidate the regulatory mechanisms of pimpled egg production in chickens: Multi-omics analysis of the mechanism of pimpled egg formation. [PDF]

Poult Sci
Li W, Ma X, Li X, Zhang X, Sun Y, Ning C, Zhang Q, Wang D, Tang H.   +8 more
europepmc   +1 more source

Spatio‐Temporal Processes of Diffusion‐Controlled Communication in Hierarchical Multi‐Compartments

Angewandte Chemie, EarlyView.
This study highlights the molecular communication of neighboring biomimetic populations in pH‐responsive hierarchically and non‐covalently organized multi‐compartments (HMC) through the assembly of micro‐ and nanocompartments. HMC unify key roles for cyclic spatio‐temporal diffusion processes and spatio‐temporal enzyme(‐like) reactions.
Xin Qiao, Haixu Chen, Andreas Schurig, Xiaoliang Wang, Yinyong Sun, Matthias Tobler, Susanne Boye, Kathrin Castiglione, Dietmar Appelhans, Xin Huang   +9 more
wiley   +1 more source

Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression. [PDF]

Biomolecules
Arnhold J.
europepmc   +1 more source

On‐Demand Ligate and Release Strategy Based on Photoclick Reaction in Tandem with Pd‐Mediated Deallylation

Angewandte Chemie, EarlyView.
A consecutive, controllable, and revertible new‐to‐nature ligation and cleavage strategy has been rationally devised to selectively visualize and manipulate biomolecules of interest. The photoclick cycloaddition between allenyl phenyl ether motifs and 9,10‐phenanthrenequinone analogues installed a terminal allyl handle at the exocyclic site, thereby ...
Boon Shing Loh, Hanqing Pang, Soh Wah Yong, Cheng Weng, Wee Han Ang   +4 more
wiley   +1 more source

Rapid Water Permeation by Aramid Foldamer Nanochannels With Hydrophobic Interiors. [PDF]

Angew Chem Int Ed Engl
Farooq S, Malla JA, Nedyalkova M, Freire RVM, Mandal I, Crochet A, Salentinig S, Lattuada M, McTernan CT, Kilbinger AFM.   +9 more
europepmc   +1 more source

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates

Angewandte Chemie, EarlyView.
SNAPR is a ribozyme that repurposes O6‐benzylguanine SNAP‐tag substrates for site‐specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. The N1A‐alkylated RNA products were converted to N6A‐modified RNA by Dimroth rearrangement.
Manisha B. Walunj, Carolin P. M. Scheitl, Tina Jungnickel, Claudia Höbartner   +3 more
wiley   +1 more source

The spectrum of lysosomal stress and damage responses: from mechanosensing to inflammation. [PDF]

EMBO Rep
Scott O, Saran E, Freeman SA.
europepmc   +1 more source