Results 71 to 80 of about 233,059 (308)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase from Acinetobacter baumannii for crafting innovative antimicrobial treatments

Journal of Enzyme Inhibition and Medicinal Chemistry
This study refers to the intricate world of Acinetobacter baumannii, a resilient pathogenic bacterium notorious for its propensity at antibiotic resistance in nosocomial infections. Expanding upon previous findings that emphasised the bifunctional enzyme
Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran, Clemente Capasso   +3 more
doaj   +1 more source

Separation and Analysis of Anions Based on Anion Carriers

Analytical Sciences, 1991
Two approaches are proposed for use of anion carriers. The first approach is development of an adsorbent specific to nitrite based on cobalt(III) complexes of 6-octadecyl-1, 4, 8, 11-tetraazacyclotetradecane-5, 7-dione impregnated in Amberlite XAD-7. The second one is spectrophotometric determination of fluoride followed by selective extraction with ...
JYO, AKINORI, TANOUE, TOMOKO, ETO, KAZUNORI, EGAWA, HIROAKI   +3 more
openaire   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Qualitative analysis of anions. Cathodic stripping voltammetry for anions quantification [PDF]

, 2021
Inorganic anions comprise a large class of organic and inorganic species that find applicability in all subjects of chemistry, pharmacy and medicine. In this lecture we give a systematic approach for qualitative analysis of inorganic anions.
Gulaboski, Rubin
core   +2 more sources

Assessment of the Water Quality of the Odugbo River in Benue State, Nigeria for Irrigation Farming

International Journal of Emerging Research in Engineering, Science, and Management
Food insecurity remains a pressing global issue, particularly in rapidly growing communities such as Odugbo, which may face challenges in sustaining food supply due to increasing population pressure.
Alfa Unekwu Dickson, Umonye Eunice Elachi   +1 more
doaj   +1 more source

New Theoretical Model of Nerve Conduction in Unmyelinated Nerves

Frontiers in Physiology, 2017
Nerve conduction in unmyelinated fibers has long been described based on the equivalent circuit model and cable theory. However, without the change in ionic concentration gradient across the membrane, there would be no generation or propagation of the ...
Tetsuya Akaishi, Tetsuya Akaishi
doaj   +1 more source

Anion/anion exchange in human neutrophils. [PDF]

The Journal of general physiology, 1986
Of the total one-way chloride fluxes (approximately 1.4 meq/liter cell water X min) in steady state human polymorphonuclear leukocytes bathed in 148 mM Cl media, approximately 70% behaves as self-exchange mediated by a nonselective anion carrier that is not inhibited by stilbene disulfonates.
L, Simchowitz, R, Ratzlaff, P, De Weer
openaire   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Carbonic Anhydrase from Porphyromonas Gingivalis as a Drug Target

Pathogens, 2017
Periodontitis originates from a microbial synergy causing the development of a mouth microbial imbalance (dysbiosis), consisting of a microbial community composed of anaerobic bacteria.
Claudiu T. Supuran, Clemente Capasso
doaj   +1 more source