Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho+12 more
wiley +1 more source
Correlational analysis between joint-level kinetics of countermovement jumps and weightlifting derivatives [PDF]
The purpose of this study was to investigate the mechanical similarity between net joint moments (NJM) of the countermovement jump (CMJ) and the hang power clean (HPC) and jump shrug (JS).
Comfort, P, Kipp, K, Suchomel, TJ
core +2 more sources
Optimal control of ankle joint moment: Toward unsupported standing in paraplegia [PDF]
This paper considers part of the problem of how to provide unsupported standing for paraplegics by feedback control. In this work our overall objective is to stabilize the subject by stimulation only of his ankle joints while the other joints are braced,
Barr, F.M.D.+3 more
core +1 more source
Advances in Medical Devices for Augmented Acupuncture Therapy
Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai+7 more
wiley +1 more source
Background Logsplitter Injury is a type of high-energy ankle fracture dislocation. The mechanism of injury has not been described in detail. A detailed understanding of the radiological features and pathological changes can further guide treatment ...
Jing-Qi Liang+6 more
doaj +1 more source
Two-week joint mobilization intervention improves self-reported function, range of motion, and dynamic balance in those with chronic ankle instability [PDF]
We examined the effect of a 2-week anterior-to-posterior ankle joint mobilization intervention on weight-bearing dorsiflexion range of motion (ROM), dynamic balance, and self-reported function in subjects with chronic ankle instability (CAI).
Andreatta, Richard D.+6 more
core +2 more sources
Wide Linearity Range and Rapid‐Response Tactile Sensor Inspired by Parallel Structures
Inspired by parallel structures, a composite tactile sensor design is proposed using parallel elastomer integration, developing two novel sensors. This strategy optimizes the force‐electric response and viscoelastic hysteresis of the conductive composite, achieving a balanced enhancement of linear sensing range and fast response.
Weihua Gao+7 more
wiley +1 more source
The Ottawa ankle rules for the use of diagnostic X-ray in after hours medical centres in New Zealand [PDF]
Aims: The aims of this study were to measure baseline use of Ottawa ankle rules (OAR), validate the OAR and, if appropriate, explore the impact of implementing the Rules on X-ray rates in a primary care, after hours medical centre setting. Methods:
Dowell, Anthony+6 more
core
Full gait cycle analysis of lower limb and trunk kinematics and muscle activations during walking in participants with and without ankle instability [PDF]
This document is the Accepted Manuscript version of the following article: Lynsey Northeast, Charlotte N. Gautrey, Lindsay Bottoms, Gerwyn Hughes, Andrew C. S.
Davis+29 more
core +5 more sources
An e‐skin with asymmetric adhesion and textured surface is fabricated. It features an adhesive base and a nonadhesive upper interface, which enables efficient real‐time monitoring of human signals and ensures stable acquisition and transmission of EEG/EMG to facilitate robotic arm manipulation.
Haiyu Li+5 more
wiley +1 more source