Results 91 to 100 of about 53,461 (270)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden   +3 more
wiley   +1 more source

Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]

open access: yes, 1993
In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A.   +2 more
core  

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

open access: yesCell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao   +9 more
wiley   +1 more source

Reproductive health in women with ankylosing spondylitis: contraception and fertility. A narrative review

open access: yesReumatismo
Objective. The knowledge of ankylosing spondylitis is rising, and more and more attention is being paid to the diagnosis of this pathology in females.
L. Marin, A. Andrisani
doaj   +1 more source

Impact of adalimumab treatment on impairment of non‐professional activities in psoriasis patients

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Psoriasis can result in reduced quality of life, work productivity loss, and a significant restriction in non‐professional activities. This study investigates the effects of long‐term treatment with adalimumab regarding work ability, non‐professional activities, and health‐related quality of life in a large real‐word ...
Georgios Kokolakis   +4 more
wiley   +1 more source

Physiotherapy In Ankylosing Spondylitis

open access: yesJournal of Education, Health and Sport, 2018
Balcerska Kamila, Bielejewska Marta, Gąsior Paulina, Wrzesiński Bartłomiej. Physiotherapy in ankylosing spondylitis. Journal of Education, Health and Sport. 2018;8(9):1576-1583 eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1438093 http://ojs.ukw.edu.pl/index.php/johs/article/view/6094 https://pbn.nauka.gov.pl/sedno-webapp/works/879772
Kamila Balcerska   +3 more
openaire   +3 more sources

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas   +11 more
wiley   +1 more source

Association between ED in ankylosing spondylitis: a population-based study

open access: yes, 2017
Even though a growing number of studies have found that patients with ankylosing spondylitis (AS) suffer from sexual problems, only very few studies have specifically addressed the relationship between AS and ED.
劉詩彬   +1 more
core   +1 more source

OSTEOPOROSIS IN PATIENTS WITH ANKYLOSING SPONDYLITIS

open access: yesФундаментальная и клиническая медицина, 2019
Currently, rheumatologists consider osteoporosis as a complication of ankylosing spondylitis, however, in recent years, it is discussed as a comorbidity but not a complication.
TATIANA A. Raskina   +3 more
doaj  

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