B3GNT2, GPR35, PSMG1 Gene Polymorphisms Are Related With Susceptibility and Severity of Ankylosing Spondylitis in Chinese Han Population. [PDF]
Mol Genet Genomic MedB3GNT2, GPR35, and PSMG1genes are related to ankylosing spondylitis in the Chinese Han population. ABSTRACT Background Latest research on ankylosing spondylitis (AS) indicates a link between the B3GNT2, PSMG1 genes and susceptibility to AS among western populations.
Lian Z +8 more
europepmc +2 more sources
Persistencia de medicamentos biológicos durante ocho años en pacientes con artritis reumatoide y espondiloartritis [PDF]
, 2019 Objective: To calculate the persistence, over a period of eight years, the retention rate of first and second-line of treatment with biological agents in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis and to compare ...
Balsa, Alejandro +5 more
core +3 more sources
IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
Arthritis Research & Therapy, 2018 BackgroundIL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony ankylosis.
S. Jo +9 more
semanticscholar +1 more source
Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome
Advanced Science, EarlyView.Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang +13 more
wiley +1 more source
Advanced Medical JournalBackground and objectives: Ankylosing spondylitis impacts the fibers and synovial tissues of the sacroiliac and spinal joint and is most noticeable commencement occurs in males.
Shahla Taha Ahmad, Shwan Kader Media
doaj +1 more source
Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]
, 1993 In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A. +2 more
core
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]
, 2017 Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo +13 more
core +2 more sources
Recent advances in ankylosing spondylitis: understanding the disease and management
F1000Research, 2018 The term spondyloarthritis refers to a group of immune-mediated diseases characterised by inflammation of the axial skeleton, peripheral joints, and entheses.
L. Garcia-Montoya, H. Gul, P. Emery
semanticscholar +1 more source
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
An epidemiological assessment of lens opacifications that impaired vision in patients injected with radium-224 [PDF]
, 1988 The incidence of lens opacifications that impaired vision (cataract) was analyzed among 831 patients who were injected with known dosages of 224Ra in Germany shortly after World War II.
Chmelevsky, D. +4 more
core +1 more source