Results 211 to 220 of about 9,109,837 (237)

Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development

Neuron, 2020
Variants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known.
Sehyoun Yoon, Euan Parnell, Maria Kasherman   +2 more
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Ankyrin(g) ETS domains to DNA

Nature Structural Biology, 1998
The crystal structure of the heterodimeric transcriptional regulator GABPα/β bound to DNA reveals extensive protein–protein interactions between an ETS domain and ankyrin repeats that may influence DNA binding affinity.
Kathryn R. Ely, Ramadurgam Kodandapani
openaire   +1 more source

Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain

Journal of Clinical Neuroscience, 2004
Ankyrin G has recently been shown to be responsible for activation of sodium channels in the developing and regenerating axonal membrane. Via this sodium channel mechanism, elevated ankyrin G levels have been linked with spontaneous ectopic hyperexcitability and thus with pain phenomena in nervous tissue.
Thomas, Kretschmer, Doan H, Nguyen, Roger W, Beuerman, Robert L, Tiel, David G, Kline   +4 more
openaire   +2 more sources

Ankyrin-G Regulates Inactivation Gating of the Neuronal Sodium Channel, Nav1.6

Journal of Neurophysiology, 2006
Ankyrin-G, a modular protein, plays a critical role in clustering voltage-gated sodium channels (Nav channels) in nodes of Ranvier and initial segments of mammalian neurons. However, direct effects of ankyrin-G on electrophysiological properties of Nav channels remain elusive.
Emi, Shirahata, Hirohide, Iwasaki, Masahiro, Takagi, Changqing, Lin, Vann, Bennett, Yasushi, Okamura, Kiyoshi, Hayasaka   +6 more
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Biochemical and functional characterization of giant ankyrin-G

2021
Ankyrins link diverse ion channels and cell adhesion molecules to the spectrin-based cytoskeleton which stabilizes membranes and regulates physiological processes in various excitable and mechano-resistant tissues and cells. They are regarded as key scaffold proteins at these domains. Three members can be found in vertebrate ankyrin family: ankyrin-R/B/
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Painful human neuromas: a potential role for a structural transmembrane protein, ankyrin G

Journal of Neurosurgery, 2002
Object. Severe nerve injury induces the formation of a neuroma. Some neuromas cause excruciating pain. Overexpression of Na+ channels leads to hyperexcitability and painful phenomena. Ankyrin G, a multifunctional transmembrane protein of the axolemma, might be a key protein in neuroma formation because it binds Na+ channels in the initial segments of a
Thomas, Kretschmer, Doan H, Nguyen, Roger W, Beuerman, Leo T, Happel, John D, England, Robert L, Tiel, David G, Kline   +6 more
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Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non‐conservative amino acid change in a short isoform of ankyrin G

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012
AbstractSignificant association between polymorphisms at the ANK3 gene with bipolar disorder has previously been reported and confirmed in several samples. Here we report on association between ANK3 and bipolar disorder in a new sample of 593 patients and 642 controls (UCL2) as well as the results of sequencing of the exons and flanking regions of ANK3
Alexandra, Dedman, Andrew, McQuillin, Radhika, Kandaswamy, Sally, Sharp, Adebayo, Anjorin, Hugh, Gurling   +5 more
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Mechanistic studies of ankyrin-B/ankyrin-G autoinhibition and regulation

2015
Ankyrins are a family of scaffold proteins, which serves to link great varieties of functional related but structurally diverse integral membrane proteins to the spectrin-based cytoskeletons. In vertebrates, the Ankyrin family consists of three members: ankyrin-R (AnkR), ankyrin-B (AnkB) and ankyrin-G (AnkG), encoded by ANK1, ANK2 and ANK3 ...
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Axonal spines in Purkinje cells of ankyrin-G-deficient mice

2006
Spiny membranous protrusions receiving excitatory synaptic input are a characteristic feature of dendrites. Here we demonstrate that spines can be induced in axons by interfering with the structural integrity of the axon initial segment (AIS). Axonal spines were identified in a mouse model with a cerebellum-specific knock-out for ankyrin-G (AnkG). AnkG
Schultz, C., Ghebremedhin, E., Del Turco, D., Politi, C., Bennett, V., Deller, T.   +5 more
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Regulation of Ankyrin-G on Nav1.5 Channel in Hypoxic HL-1 Cardiac Muscle Cells

Discovery Medicine
Hypoxia has a major regulatory impact on the electrical activity transmission in the myocardium, and it is involved in the development of tachyarrhythmia disease. Anchor protein G (ankyrin-G, ANK-G) is associated with voltage-gated Na+ channels (Nav1.5), but its specific role and mechanism have not been fully defined.
Shanshan, Ma, Shuqin, Yang, Peng, Xu, Wenshui, Li, Yang, Wang, Chenyang, Wang, Heling, Huang, Yang, Li, Xuebin, Cao   +8 more
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