Results 1 to 10 of about 28,493 (107)

Actin polymerization and longitudinal actin fibers in axon initial segment plasticity [PDF]

Frontiers in Molecular Neuroscience
The location of the axon initial segment (AIS) at the junction between the soma and axon of neurons makes it instrumental in maintaining neural polarity and as the site for action potential generation. The AIS is also capable of large-scale relocation in
David Micinski, David Micinski, Pirta Hotulainen, Pirta Hotulainen   +3 more
doaj   +4 more sources

Immunoproximity biotinylation reveals the axon initial segment proteome [PDF]

Nature Communications, 2023
The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge ...
Wei Zhang, Yu Fu, Luxin Peng, Yuki Ogawa, Xiaoyun Ding, Anne Rasband, Xinyue Zhou, Maya Shelly, Matthew N. Rasband, Peng Zou   +9 more
doaj   +2 more sources

Pyramidal cell axon initial segment in Alzheimer´s disease [PDF]

Scientific Reports, 2022
The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity.
Alejandro Antón-Fernández, Gonzalo León-Espinosa, Javier DeFelipe, Alberto Muñoz   +3 more
doaj   +2 more sources

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets [PDF]

MedComm
The axon initial segment (AIS) is a specialized neuronal microdomain that serves as a physical diffusion barrier, separating the axon from somatodendritic compartments.
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
doaj   +2 more sources

The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling

Cell Reports, 2019
Summary: The axon initial segment (AIS) is a compartment that serves as a molecular barrier to achieve axon-dendrite differentiation. Distribution of specific proteins during early neuronal development has been proposed to be critical for AIS ...
Sotaro Ichinose, Tadayuki Ogawa, Xuguang Jiang, Nobutaka Hirokawa   +3 more
doaj   +3 more sources

Contribution of Axon Initial Segment Structure and Channels to Brain Pathology [PDF]

Cells, 2023
Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
doaj   +2 more sources

Oxidative Stress Induces Disruption of the Axon Initial Segment

ASN Neuro, 2017
The axon initial segment (AIS), the domain responsible for action potential initiation and maintenance of neuronal polarity, is targeted for disruption in a variety of central nervous system pathological insults.
Kareem C. Clark, Brooke A. Sword, Jeffrey L. Dupree   +2 more
doaj   +2 more sources

Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease [PDF]

MedComm
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid‐β (Aβ) and hyperphosphorylated tau.
Yu Li, Han Wang, Yiming Wang, Zhiya Chen, Yiqiong Liu, Wu Tian, Xinrui Kang, Abolghasem Pashang, Don Kulasiri, Xiaoli Yang, Hung Wing Li, Yan Zhang   +11 more
doaj   +2 more sources

Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]

Biomolecules
The axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu, Yanyan Yu, Zhuqian Jiang, Yoshinori Otani, Masashi Fujitani   +4 more
doaj   +2 more sources

The axon initial segment as a source of neuropathic pain [PDF]

Brain, 2022
Ana Dorrego-Rivas, Matthew S Grubb
exaly   +2 more sources