The axon initial segment as a source of neuropathic pain [PDF]
Brain, 2022 This scientific commentary refers to ‘Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain’ by Nascimento et al. (https://doi.org/10.1093/brain/awac078)
Ana Dorrego-Rivas, Matthew S Grubb
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Actin polymerization and longitudinal actin fibers in axon initial segment plasticity [PDF]
Frontiers in Molecular NeuroscienceThe location of the axon initial segment (AIS) at the junction between the soma and axon of neurons makes it instrumental in maintaining neural polarity and as the site for action potential generation. The AIS is also capable of large-scale relocation in
David Micinski +3 more
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Immunoproximity biotinylation reveals the axon initial segment proteome [PDF]
Nature Communications, 2023 The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge ...
Wei Zhang +9 more
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Pyramidal cell axon initial segment in Alzheimer´s disease [PDF]
Scientific Reports, 2022 The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity.
Alejandro Antón-Fernández +3 more
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Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets [PDF]
MedCommThe axon initial segment (AIS) is a specialized neuronal microdomain that serves as a physical diffusion barrier, separating the axon from somatodendritic compartments.
Dong‐Yan Song +4 more
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Cell Reports, 2019 Summary: The axon initial segment (AIS) is a compartment that serves as a molecular barrier to achieve axon-dendrite differentiation. Distribution of specific proteins during early neuronal development has been proposed to be critical for AIS ...
Sotaro Ichinose +3 more
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Contribution of Axon Initial Segment Structure and Channels to Brain Pathology [PDF]
Cells, 2023 Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
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Oxidative Stress Induces Disruption of the Axon Initial Segment
ASN Neuro, 2017 The axon initial segment (AIS), the domain responsible for action potential initiation and maintenance of neuronal polarity, is targeted for disruption in a variety of central nervous system pathological insults.
Kareem C. Clark +2 more
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Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease [PDF]
MedCommAlzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid‐β (Aβ) and hyperphosphorylated tau.
Yu Li +11 more
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Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]
BiomoleculesThe axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu +4 more
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