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Structural and functional plasticity at the axon initial segment [PDF]
Frontiers in Cellular Neuroscience, 2016 The axon initial segment (AIS) is positioned between the axonal and somato-dendritic compartments and plays a pivotal role in triggering action potentials and determining neuronal output.
Rei Yamada, Hiroshi Kuba
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Contribution of Axon Initial Segment Structure and Channels to Brain Pathology [PDF]
Cells, 2023 Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
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Plasticity at the axon initial segment [PDF]
Communicative & Integrative Biology, 2010 Experience dependent alterations in neural activity are mediated by diverse forms of plasticity, which are conventionally thought to occur at either synaptic terminals and/or postsynaptic membrane, such as dendrites and cell soma.
Hiroshi Kuba
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The axon initial segment as a source of neuropathic pain [PDF]
Brain, 2022 This scientific commentary refers to ‘Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain’ by Nascimento et al. (https://doi.org/10.1093/brain/awac078).
Ana Dorrego-Rivas, Matthew S Grubb
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Immunoproximity biotinylation reveals the axon initial segment proteome [PDF]
Nature Communications, 2023 The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge ...
Wei Zhang +9 more
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Channelrhodopsin-2 localised to the axon initial segment.
PLoS ONE, 2010 The light-gated cation channel Channelrhodopsin-2 (ChR2) is a powerful and versatile tool for controlling neuronal activity. Currently available versions of ChR2 either distribute uniformly throughout the plasma membrane or are localised specifically to ...
Matthew S Grubb, Juan Burrone
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Inhibitory Synapse Formation at the Axon Initial Segment [PDF]
Frontiers in Molecular Neuroscience, 2019 The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons and is thus a critical site in the regulation of neuronal excitability.
Anna J. Nathanson +4 more
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P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development [PDF]
Frontiers in Cellular Neuroscience, 2019 Morphological and functional polarization of neurons depends on the generation and maintenance of the axon initial segment (AIS). This axonal domain maintains axonal properties but is also the place where the action potential (AP) is generated. All these
Wei Zhang +5 more
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Pyramidal cell axon initial segment in Alzheimer´s disease [PDF]
Scientific Reports, 2022 The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity.
Alejandro Antón-Fernández +3 more
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Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets [PDF]
MedCommThe axon initial segment (AIS) is a specialized neuronal microdomain that serves as a physical diffusion barrier, separating the axon from somatodendritic compartments.
Dong‐Yan Song +4 more
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