Channelrhodopsin-2 localised to the axon initial segment.
PLoS ONE, 2010 The light-gated cation channel Channelrhodopsin-2 (ChR2) is a powerful and versatile tool for controlling neuronal activity. Currently available versions of ChR2 either distribute uniformly throughout the plasma membrane or are localised specifically to ...
Matthew S Grubb, Juan Burrone
doaj +4 more sources
TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment [PDF]
The Journal of Neuroscience, 2019 Selective cargo transport into axons and dendrites over the microtubule network is essential for neuron polarization. The axon initial segment (AIS) separates the axon from the somatodendritic compartment and controls the microtubule-dependent transport ...
Motshagen, Jasmijn +18 more
core +6 more sources
Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment [PDF]
eLife, 2020 Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability.
Aniket Ghosh +3 more
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Theoretical relation between axon initial segment geometry and excitability
eLife, 2020 In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial segment (AIS). Both position and length of the AIS vary across and within neuron types, with activity, development and pathology.
Sarah Goethals, Romain Brette
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Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma. [PDF]
PLoS Computational Biology, 2017 Spikelets are small spike-like depolarizations that can be measured in somatic intracellular recordings. Their origin in pyramidal neurons remains controversial.
Martina Michalikova +2 more
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Action Potential Initiation in a Damaged Axon Initial Segment
, 2016 We constructed a model for the initiation of the action potential (AP) in a damaged axon initial segment(AIS). We modelled the full axon including the AIS with a system of partial differential equations that we solved numerically.
Jacques, Louis
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Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment [PDF]
Frontiers in Cellular Neuroscience, 2017 The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motors determines the destination and selectivity of transport,
Anne F. J. Janssen +5 more
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Alterations of the axon initial segment in multiple sclerosis grey matter. [PDF]
Brain Commun, 2022 Grey matter damage has been established as a key contributor to disability progression in multiple sclerosis. Aside from neuronal loss and axonal transections, which predominate in cortical demyelinated lesions, synaptic alterations have been detected in
Senol AD +8 more
europepmc +2 more sources
Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development. [PDF]
J Neurosci, 2023 Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials (APs) to downstream targets. Neuronal polarity is maintained by the axon initial segment (AIS),
Lipkin AM, Bender KJ.
europepmc +2 more sources
Axon initial segment geometry in relation to motoneuron excitability.
PLoS ONE, 2021 The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability.
Travis M Rotterman +5 more
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