Results 1 to 10 of about 144,668 (268)
Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters
Nature Communications, 2023 The potassium channel selectivity filter is responsible for conduction and selectivity of K + over other cations. Here, the authors use a combination of single molecule FRET, non-canonical fluorescent amino acid incorporation, and single channel patch ...
Marcos Matamoros +4 more
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Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS
EMBO Molecular Medicine, 2023 ABCC9‐related intellectual disability and myopathy syndrome (AIMS) arises from loss‐of‐function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP‐sensitive potassium (KATP) channels.
Conor McClenaghan +7 more
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Nature Communications, 2022 Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel.
Guohui Zhang +12 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Cardiomegaly caused by left ventricular hypertrophy is a risk factor for development of congestive heart failure, classically associated with decreased systolic and/or diastolic ventricular function.
Gautam K. Singh +6 more
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Neuron, 2019 Engram cells can encode and switch between multiple mnemonic functions, but how they intrinsically do so is unknown. Pignatelli, Ryan, and colleagues show that upon memory recall, the engram's excitability is transiently elevated, allowing its bearer to adapt to changing environments.
Albo, Zimbul, Gräff, Johannes
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Activation of the archaeal ion channel MthK is exquisitely regulated by temperature
eLife, 2020 Physiological response to thermal stimuli in mammals is mediated by a structurally diverse class of ion channels, many of which exhibit polymodal behavior.
Yihao Jiang +3 more
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Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels
Function, 2023 Physiological activity of G protein gated inward rectifier K+ (GIRK, Kir3) channel, dynamically regulated by three key ligands, phosphoinositol-4,5-bisphosphate (PIP2), Gβγ, and Na+, underlies cellular electrical response to multiple hormones and ...
Sun-Joo Lee +3 more
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Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility
eLife, 2023 Prestin responds to transmembrane voltage fluctuations by changing its cross-sectional area, a process underlying the electromotility of outer hair cells and cochlear amplification.
Xiaoxuan Lin +5 more
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Exciting and not so exciting roles of pannexins [PDF]
Neuroscience Letters, 2019 It is the current view that purinergic signaling regulates many physiological functions. Pannexin1 (Panx1), a member of the gap junction family of proteins is an ATP releasing channel that plays important physio-pathological roles in various tissues, including the CNS.
Eliana, Scemes, Jana, Velíšková
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eLife, 2014 Voltage-gated ion channels generate electrical currents that control muscle contraction, encode neuronal information, and trigger hormonal release. Tissue-specific expression of accessory (β) subunits causes these channels to generate currents with ...
Mark A Zaydman +10 more
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