Results 1 to 10 of about 1,614 (118)

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS [PDF]

EMBO Molecular Medicine, 2023
ABCC9‐related intellectual disability and myopathy syndrome (AIMS) arises from loss‐of‐function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP‐sensitive potassium (KATP) channels.
Conor Mcclenaghan, Jacob Roeglin, Manfred Grabner   +2 more
exaly   +3 more sources

Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension

Frontiers in Cardiovascular Medicine, 2023
AimsWe hypothesized that the ATP-sensitive K+ channels (KATP) regulatory subunit (ABCC9) contributes to PAH pathogenesis. ABCC9 gene encodes for two regulatory subunits of KATP channels: the SUR2A and SUR2B proteins.
Mary Dutheil, Angele Boet, Véronique Capuano   +2 more
exaly   +3 more sources

Targeting Host Sulphonyl Urea Receptor 2 Can Reduce Severity of Helicobacter pylori Associated Gastritis [PDF]

Gastro Hep Advances, 2023
Background and Aims: While most Helicobacter pylori-infected individuals remain asymptomatic throughout their lifetime, in a significant proportion, the resulting severe chronic gastritis drives the development of gastric cancer.
Sohinee Sarkar, Ghazal Alipour Talesh, Trevelyan R. Menheniott, Philip Sutton   +3 more
doaj   +2 more sources

Myocardial protection by adenosine triphosphate−sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunitCentral MessagePerspective [PDF]

JTCVS Open
Objective: Pharmacologic openers of adenosine triphosphate-sensitive potassium (KATP) channels mimic ischemic preconditioning and are cardioprotective.
Jie Wang, MD, AlleaBelle Bradshaw, MD, Robert Tryon, PhD, Rachel Pan, Sari D. Holmes, PhD, Colin Nichols, PhD, Jennifer S. Lawton, MD   +6 more
doaj   +2 more sources

Pulmonary hypertension associated with diazoxide: the SUR1 paradox [PDF]

ERJ Open Research, 2023
The ATP-sensitive potassium channels and their regulatory subunits, sulfonylurea receptor 1 (SUR1/Kir6.2) and SUR2/Kir6.1, contribute to the pathophysiology of pulmonary hypertension (PH).
David Montani, Fabrice Antigny, Etienne-Marie Jutant, Marie-Camille Chaumais, Hélène Le Ribeuz, Julien Grynblat, Charles Khouri, Marc Humbert   +7 more
doaj   +2 more sources

Structural identification of vasodilator binding sites on the SUR2 subunit

Nature Communications, 2022
SUR2-containing KATP channels are drug targets for certain vasodilators. Here, the authors determine high-resolution cryo-EM structures of SUR2 in complex with two vasodilators, P1075 and levcromakalim, uncovering the mechanisms of these drugs.
Dian Ding, Jing-Xiang Wu
exaly   +2 more sources

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

JCI Insight, 2021
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by ...
Haixia Zhang, Alex Hanson, Conor Mcclenaghan   +2 more
exaly   +2 more sources

Zoledronic Acid Blocks Overactive Kir6.1/SUR2-Dependent K_ATP Channels in Skeletal Muscle and Osteoblasts in a Murine Model of Cantú Syndrome [PDF]

Cells, 2023
Cantú syndrome (CS) is caused by the gain of function mutations in the ABCC9 and KCNJ8 genes encoding, respectively, for the sulfonylureas receptor type 2 (SUR2) and the inwardly rectifier potassium channel 6.1 (Kir6.1) of the ATP-sensitive potassium ...
Rosa Scala, Fatima Maqoud, Conor McClenaghan, Theresa M. Harter, Maria Grazia Perrone, Antonio Scilimati, Colin G. Nichols, Domenico Tricarico   +7 more
doaj   +2 more sources

Gain-of-function mutations in KATP channel subunits compromise colonic tight junction integrity and epithelial homeostasis in murine models of Cantú syndrome [PDF]

Frontiers in Medicine
IntroductionCantú syndrome (CS) is a rare genetic disorder caused by gain-of-function (GOF) mutations in the KCNJ8 (Kir6.1) or ABCC9 (SUR2) subunits of ATP-sensitive potassium (KATP) channels.
Fatima Maqoud, Domenica Mallardi, Antonella Orlando, Domenico Tricarico, Colin G. Nichols, Marina Antonacci, Giusy Bianco, Raffaele Armentano, Ilaria Grassi, Anna Maria Valentini, Francesco Russo   +10 more
doaj   +2 more sources

The IAOx-Dependent IAA Biosynthesis Pathway: Acquired Insights, Paradigm Shifts, and Unresolved Questions [PDF]

Plants
The auxin indole-3-acetic acid (IAA) is essential for plant growth and stress adaptation. Its biosynthesis via the indole-3-acetaldoxime (IAOx) pathway has recently undergone a paradigm shift.
Ming-Kun Ma, Verena Kriechbaumer, Dong-Wei Di   +2 more
doaj   +2 more sources