Results 31 to 40 of about 1,901 (173)

Requirement of Sur2 for Efficient Replication of Mouse Adenovirus Type 1 [PDF]

Journal of Virology, 2004
ABSTRACTMouse adenovirus type 1 (MAV-1) early region 1A (E1A) encodes a virulence gene in viral infection of mice. To broaden our understanding of the functions of E1A in MAV-1 pathogenesis, an unbiased experimental approach, glutathioneS-transferase (GST) pulldown, was used to screen for cellular proteins that interact with E1A protein.
Lei, Fang, Jennitte L, Stevens, Arnold J, Berk, Katherine R, Spindler   +3 more
openaire   +2 more sources

Novel cholesterol‐dependent regulation of cardiac KATP subunit expression revealed using histone deacetylase inhibitors

Physiological Reports, 2021
We recently discovered that the histone deacetylase inhibitor, trichostatin A (TSA), increases expression of the sulfonylurea receptor 2 (SUR2; Abcc9) subunit of the ATP‐sensitive K+ (KATP) channel in HL‐1 cardiomyocytes.
Robert Geiger, Naheed Fatima, James F. Schooley Jr., Jeremy T. Smyth, Mark C. Haigney, Thomas P. Flagg   +5 more
doaj   +1 more source

Genetic parameters for dairy calf and replacement heifer wellness traits and their association with cow longevity and health indicators in Holstein cattle

Journal of Dairy Science, 2022
: High mortality and involuntary culling rates cause great economic losses to the worldwide dairy cattle industry. However, there is low emphasis on wellness traits in replacement animals (dairy calves and replacement heifers) during their development ...
Hailiang Zhang, Kai Wang, Tao An, Lei Zhu, Yao Chang, Wenqi Lou, Lin Liu, Gang Guo, Aoxing Liu, Guosheng Su, Luiz F. Brito, Yachun Wang   +11 more
doaj   +1 more source

The short form of the SUR1 and its functional implications in the damaged brain

Neural Regeneration Research, 2022
Sulfonylurea receptor (SUR) belongs to the adenosine 5′-triphosphate (ATP)-binding cassette (ABC) transporter family; however, SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the pore.
Iván Alquisiras-Burgos, Javier Franco-Pérez, Moisés Rubio-Osornio, Penélope Aguilera   +3 more
doaj   +1 more source

Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension

Biomolecules, 2020
Pulmonary arterial hypertension (PAH) is a rare and severe cardiopulmonary disease without curative treatments. PAH is a multifactorial disease that involves genetic predisposition, epigenetic factors, and environmental factors (drugs, toxins, viruses ...
Hélène Le Ribeuz, Véronique Capuano, Barbara Girerd, Marc Humbert, David Montani, Fabrice Antigny   +5 more
doaj   +1 more source

Effects of Naringin on Cardiomyocytes From a Rodent Model of Type 2 Diabetes

Frontiers in Pharmacology, 2021
Diabetic cardiomyopathy (DCM) is a primary disease in diabetic patients characterized by diastolic dysfunction leading to heart failure and death. Unfortunately, even tight glycemic control has not been effective in its prevention. We have found aberrant
A. Uryash, A. Mijares, V. Flores, J. A. Adams, J. R. Lopez   +4 more
doaj   +1 more source

Cantu syndrome-associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels. [PDF]

J Biol Chem
Gain-of-function (GOF) mutations in either Kir6.1 (encoded by KCNJ8) or SUR2 (encoded by ABCC9) are causally associated with Cantu syndrome (CS), characterized by coarse facial appearance, hypertrichosis, and multiple cardiovascular abnormalities. To date, all SUR2 mutations identified in association with CS have demonstrated GOF because of reduced ATP
Gao J, Thompson ET, Nichols CG.
europepmc   +3 more sources

Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes [PDF]

Journal of Molecular and Cellular Cardiology, 2003
The subcellular distribution of ATP-sensitive potassium (K(ATP)) channel subunits in rat-isolated ventricular myocytes was investigated using a panel of subunit-specific antisera. Kir6.1 subunits were associated predominantly with myofibril structures and were co-localized with the mitochondrial marker MitoFluor red (correlation coefficient (cc) = 0.63
Singh, Harprit, Hudman, Diane, Lawrence, C.L., Rainbow, Richard Daniel, Lodwick, David, Norman, Robert I.   +5 more
openaire   +4 more sources

Allicin, a SUR2 opener: possible mechanism for the treatment of diabetic hypertension in rats [PDF]

Revista Brasileira de Farmacognosia, 2012
The garlic (Allium sativum L., Amaryllidaceae) has been popularly used in the treatment of diabetes and cardiac complications. In the present work, we have studied the possible mechanisms, sulfonylurea receptor (SUR) selectivity of allicin in diabetic hypertensive rats.
Dubey, Harikesh, Singh, Anamika, Patole, Angad Mohanrao, Tenpe, Chandrashekhar Ramdas, Ghule, Balu Vinayak   +4 more
openaire   +3 more sources

Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome

Frontiers in Pharmacology, 2022
Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channel ...
Marien J. C. Houtman, Theres Friesacher, Xingyu Chen, Eva-Maria Zangerl-Plessl, Marcel A. G. van der Heyden, Anna Stary-Weinzinger   +5 more
doaj   +1 more source