Results 1 to 10 of about 1,646 (125)

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection [PDF]

Frontiers in Physiology
IntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan, Samir Makwana, Shen Chen, Lauren R. McGuinness, Moustafa Sweihi, Jacob A. Whitmore, Mahmoud E. Elghayesh, Mahmoud E. Elghayesh, Christopher A. Martin, Noorann Sheikh, Manish Patel, Phoebe Malin, Mark W. Sims, Caroline Dart, Richard D. Rainbow   +14 more
doaj   +2 more sources

Functional expression of inwardly rectifying and ATP-sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells. [PDF]

J Physiol
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Barreira B, Morales-Cano D, Moreno L, de Olaiz B, Adão R, Cogolludo A, Perez-Vizcaino F, Sancho M.   +7 more
europepmc   +2 more sources

Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels [PDF]

Channels
Vascular smooth muscle ATP-sensitive potassium (KATP) channels play critical roles in modulating vascular tone and thus represent important drug targets for diverse cardiovascular pathologies.
Kangjun Li, Vaishali Satpute Janve, Jerod Denton   +2 more
doaj   +2 more sources

Gain-of-function mutations in KATP channel subunits compromise colonic tight junction integrity and epithelial homeostasis in murine models of Cantú syndrome [PDF]

Frontiers in Medicine
IntroductionCantú syndrome (CS) is a rare genetic disorder caused by gain-of-function (GOF) mutations in the KCNJ8 (Kir6.1) or ABCC9 (SUR2) subunits of ATP-sensitive potassium (KATP) channels.
Fatima Maqoud, Domenica Mallardi, Antonella Orlando, Domenico Tricarico, Colin G. Nichols, Marina Antonacci, Giusy Bianco, Raffaele Armentano, Ilaria Grassi, Anna Maria Valentini, Francesco Russo   +10 more
doaj   +2 more sources

Effect of Type-2 Diabetes Mellitus on the Expression and Function of Smooth Muscle ATP-Sensitive Potassium Channels in Human Internal Mammary Artery Grafts [PDF]

Pharmaceuticals
Here we have shown for the first time altered expression of the vascular smooth muscle (VSM) KATP channel subunits in segments of the human internal mammary artery (HIMA) in patients with type-2 diabetes mellitus (T2DM). Functional properties of vascular
Jovana Rajkovic, Miodrag Peric, Jelena Stanisic, Milos Gostimirovic, Radmila Novakovic, Vladimir Djokic, Snezana Tepavcevic, Jelena Rakocevic, Milica Labudovic-Borovic, Ljiljana Gojkovic-Bukarica   +9 more
doaj   +2 more sources

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development [PDF]

Frontiers in Immunology
IntroductionInvolved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to
Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee, William A. Coetzee, William A. Coetzee   +13 more
doaj   +2 more sources

Age-dependent cerebral vasodilation induced by volatile anesthetics is mediated by NG2+ vascular mural cells [PDF]

Communications Biology
Anesthesia can influence cerebral blood flow by altering vessel diameter. Using in vivo two-photon imaging, we examined the effects of volatile anesthetics, sevoflurane and isoflurane, on vessel diameter in young and adult mice.
Hang Zhou, Viola Neudecker, Jose F. Perez-Zoghbi, Ansgar M. Brambrink, Guang Yang   +4 more
doaj   +2 more sources

Acute Metabolic Stress Induces Lymphatic Dysfunction Through KATP Channel Activation [PDF]

Function
Lymphatic dysfunction is an underlying component of multiple metabolic diseases, including diabetes, obesity, and metabolic syndrome. We investigated the roles of KATP channels in lymphatic contractile dysfunction in response to acute metabolic stress ...
Hae Jin Kim, Charles E Norton, Scott D Zawieja, Jorge A Castorena-Gonzalez, Michael J Davis   +4 more
doaj   +2 more sources

KLF5 Regulation of Exosome-Derived miR-152-3p From Bone Marrow Stem Cells Improves Ventricular Arrhythmia After Myocardial Infarction. [PDF]

Stem Cells Int
Cardiac fibroblasts (CFs) are activated into cardiac myofibroblasts (CMFs) in myocardial infarction (MI) and promote fibrosis, playing a crucial role in deteriorating cardiac function and inducing fatal arrhythmias. Transplantation of bone marrow mesenchymal stem cells (BMSCs) has emerged as a promising therapeutic approach for ischemic heart diseases,
Wu C, Zou XY, Jiang YW, Lin DW, Jiang F, Wang YS.   +5 more
europepmc   +2 more sources

Trimethylamine N-oxide (TMAO) acutely alters ionic currents but does not increase cardiac cell death [PDF]

Frontiers in Physiology
BackgroundTrimethylamine N-oxide (TMAO) is a product of the action of gut microbiota on choline and other choline-containing compounds ingested in the diet.
Simona Esposito, Simona Esposito, Lauren R. McGuinness, Parveen Sharma, Amy E. Chadwick, Richard D. Rainbow   +5 more
doaj   +2 more sources