KATP channels and cardioprotection [PDF]
Arhiv za farmacijuThis review discusses ATP-sensitive potassium (KATP) channels, which connect intracellular energy metabolism to cellular electrical activity and play crucial roles in various physiological processes, particularly in the pancreas and cardiovascular system.
Taskin Eylem +5 more
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KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies [PDF]
Frontiers in NeurologyCumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as ...
Hassan Ali Suleiman Daoud +4 more
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Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases [PDF]
Frontiers in Pharmacology, 2022 ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate ...
Zhicheng Wang +4 more
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Endocytosis of KATP Channels Drives Glucose-Stimulated Excitation of Pancreatic β Cells
Cell Reports, 2018 Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depends on the inhibition of KATP channel activity in HG.
Young-Eun Han +10 more
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KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology [PDF]
JCI Insight, 2023 Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer’s disease (AD).
John Grizzanti +21 more
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Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels [PDF]
Channels, 2022 ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection.
Bo Yang +6 more
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Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell KATP channels [PDF]
Frontiers in PhysiologyATP-sensitive potassium (KATP) channels link beta-cell metabolism to electrical activity. By modulating the beta-cell membrane potential, they finely regulate glucose-stimulated insulin secretion.
Natascia Vedovato +5 more
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Sodium butyrate activates the KATP channels to regulate the mechanism of Parkinson's disease microglia model inflammation [PDF]
Immunity, Inflammation and DiseaseBackground Parkinson's disease (PD) is a common neurodegenerative disorder. Microglia‐mediated neuroinflammation has emerged as an involving mechanism at the initiation and development of PD. Activation of adenosine triphosphate (ATP)‐sensitive potassium
Ye Xu +6 more
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Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
Royal Society Open Science, 2017 ATP-sensitive potassium channels (KATP channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, KATP channels are essential for coupling glucose metabolism to insulin secretion.
Christopher H. Emfinger +8 more
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Pharmaceutics, 2021 Zoledronic acid (ZOL) is used as a bone-specific antiresorptive drug with antimyeloma effects. Adverse drug reactions (A.D.R.) are associated with ZOL-therapy, whose mechanics are unknown.
Fatima Maqoud +6 more
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