Results 41 to 50 of about 14,064 (215)

Participation of KАТР-channels of plasma and mitochondrial membranes in the regulation of mechanokinetics of rat myometrium spontaneous contractions

Біологічні студії, 2022
Background. ATP-sensitive K+ channels of the plasma membrane in the smooth muscles of the uterus are one of the most significant ion channels that regulate the excitability of this tissue both in the non-pregnant state and during pregnancy.
O. V. Tsymbalyuk, O. B. Vadzyuk, I. S. Voiteshenko, V. D. Ivanova   +3 more
doaj   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels

Frontiers in Physiology, 2022
There is strong evidence that the omega-3 polyunsaturated fatty acids (n-3 PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have cardioprotective effects.
Cristiana Bercea, Cristiana Bercea, Roshan Limbu, Kamila Behnam, Keat-Eng Ng, Qadeer Aziz, Andrew Tinker, Francesco Tamagnini, Graeme S Cottrell, Alister J McNeish   +9 more
doaj   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Role of KATP channels in angiogenesis [PDF]

, 2021
Σε πολλά εργαστήρια, σε παγκόσμιο επίπεδο, συντελείται σημαντική ερευνητική προσπάθεια για την ταυτοποίηση νέων μοριακών μηχανισμών στο πεδίο της αγγειογένεσης ως στόχων ανάπτυξης φαρμάκων, καθώς η θεραπευτική ρύθμιση της αγγειογένεσης μπορεί να επηρεάσει σημαντικά την εξέλιξη πολλών ασθενειών.
openaire   +1 more source

Membrane trafficking of ATP-sensitive potassium channels [PDF]

, 2005
ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
core  

Expression of ATP-sensitive potassium channels in human pregnant myometrium

Reproductive Biology and Endocrinology, 2011
Background Potassium channels play critical roles in the regulation of cell membrane potential, which is central to the excitability of myometrium. The ATP-sensitive potassium (KATP) channel is one of the most abundant potassium channels in myometrium ...
Hui Ning, Hu Rong, Zhang Lanmei, Gao Lu, You Xingji, Xu Chen, Olson David M, Ni Xin   +7 more
doaj   +1 more source

Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion

BMC Research Notes, 2023
Objective Insulin secretion is regulated by ATP-sensitive potassium (KATP) channels in pancreatic beta-cells. Peroxisome proliferator-activated receptors (PPAR) α ligands are clinically used to treat dyslipidemia.
Shigeki Kitamura, Naoya Murao, Shoko Yokota, Masaru Shimizu, Tomoyuki Ono, Yusuke Seino, Atsushi Suzuki, Yuko Maejima, Kenju Shimomura   +8 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source