Endocytosis of KATP Channels Drives Glucose-Stimulated Excitation of Pancreatic β Cells
Cell Reports, 2018 Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depends on the inhibition of KATP channel activity in HG.
Myong-Ho Jeong +2 more
exaly +3 more sources
The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel
Cell Reports, 2019 Summary: Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive potassium channel (KATP).
Yunlu Kang, Jing-Xiang Wu
exaly +3 more sources
Neuroprotective effect of nicorandil in 6-OHDA induced in vitro model of parkinson's disease
Medicine Science, 2022 The purpose of this study was to examine the consequences of opening KATP channels using nicorandil in an in vitro 6-OHDA Parkinsons disease model conducted in SH-SY5Y cells.
Ufuk Okkay, Irmak Ferah Okkay
doaj +1 more source
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Channels, 2022 ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection.
Bo Yang +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate ...
Zhicheng Wang +4 more
doaj +1 more source
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
Royal Society Open Science, 2017 ATP-sensitive potassium channels (KATP channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, KATP channels are essential for coupling glucose metabolism to insulin secretion.
Christopher H. Emfinger +8 more
doaj +1 more source
Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides
Nature Communications, 2022 KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.
Mengmeng Wang +3 more
doaj +1 more source
Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. [PDF]
PLoS ONE, 2016 The search for new approaches to treatment and prevention of heart failure is a major challenge in medicine. The adenosine triphosphate-sensitive potassium (KATP) channel has been long associated with the ability to preserve myocardial function and ...
Zhan Gao +8 more
doaj +1 more source
Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves
iScience, 2022 Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce ...
Hiromi Nakai-Shimoda +18 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh +2 more
doaj +1 more source