Results 11 to 20 of about 17,716 (217)
KATP channels and cardioprotection [PDF]
Arhiv za farmacijuThis review discusses ATP-sensitive potassium (KATP) channels, which connect intracellular energy metabolism to cellular electrical activity and play crucial roles in various physiological processes, particularly in the pancreas and cardiovascular system.
Taskin Eylem +5 more
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BAD and KATP channels regulate neuron excitability and epileptiform activity [PDF]
eLife, 2018 Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures ...
Juan Ramón Martínez-François +6 more
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Regulation of KATP channel activity
, 2021 ATP-sensitive potassium (KATP) channels are present in many tissues, most notably pancreatic islets and cardiac cells, where they couple the metabolic state of a cell to its electrical activity by regulating the flow of K+ across the membrane in response to the intracellular ATP/ADP ratio.
Usher, Samuel
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Zebrafish Models of KATP Channelopathies
, 2021 Much work has been carried out to understand the composition, structure, and function of ATP-sensitive potassium (KATP) channels in mammalian tissues, as well as the molecular basis of the channelopathies that result from loss-of-function or gain-of ...
Singareddy, Soma S
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Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells [PDF]
International Journal of Photoenergy, 2014 Background and Objective. ATP-sensitive potassium (KATP) channel couples cell metabolism to excitability. To explore role of KATP channels in cellular photobiomodulation, we designed experiment to study effect of low intensity 808 nm laser irradiation on
Fu-qing Zhong, Yang Li, Xian-qiang Mi
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The Pharmacology of ATP-Sensitive K+ Channels (KATP)
, 2021 ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels thus playing an important physiological role by coupling cellular metabolism with membrane excitability.
Li, Y, Aziz, Q, Tinker, A
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Regulation of mitochondrial KATP channel by redox agents
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999 The ATP-dependent K+ channel (KATP) was purified from the inner mitochondrial membrane and reconstituted into lipid bilayer membranes. KATP activity was inhibited by high concentrations of ATP and ADP, but activated by low concentrations (up to 200 microM) of ADP.
Grigoriev, S.M. +3 more
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Cardiovascular consequences of KATP overactivity in Cantu syndrome [PDF]
JCI Insight, 2018 Cantu syndrome (CS) is characterized by multiple vascular and cardiac abnormalities including vascular dilation and tortuosity, systemic hypotension, and cardiomegaly. The disorder is caused by gain-of-function (GOF) mutations in genes encoding pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits ...
Yan Huang +12 more
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Nature's KATP-Channel Knockout
Physiology, 1997 We describe here how ion-channel dysfunction in b-cells is associated with the pathogenesis of a potentially lethal condition in newborn children and early infancy. We review how nature's KATP-channel knockout has important medical implications and how key lessons in physiology can be learned from studies of rare diseases.
MJ Dunne, A Aynsley-Green, KJ Lindley
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Mechanical effects on KATP channel gating in rat ventricular myocytes.
PLoS ONE, 2013 Cardiac KATP channels link metabolism with electrical activity. They are implicated in arrhythmias, secretion of atrial natriuretic peptide and protection of the heart from hypertrophy and failure. These processes may involve mechanosensitivity.
Haixia Huang +6 more
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