Results 11 to 20 of about 19,437 (170)
KATP channels and cardioprotection [PDF]
Arhiv za farmacijuThis review discusses ATP-sensitive potassium (KATP) channels, which connect intracellular energy metabolism to cellular electrical activity and play crucial roles in various physiological processes, particularly in the pancreas and cardiovascular system.
Taskin Eylem +5 more
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BAD and KATP channels regulate neuron excitability and epileptiform activity [PDF]
eLife, 2018 Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures ...
Juan Ramón Martínez-François +6 more
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Inhibition Mechanism of Pancreatic KATP Channels by Centipede Toxin [PDF]
ResearchThe pancreatic adenosine triphosphate (ATP)-sensitive potassium (KATP) channel acts as a crucial metabolic sensor, regulating insulin secretion to maintain whole-body energy homeostasis.
Tianyi Hou +4 more
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Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells [PDF]
International Journal of Photoenergy, 2014 Background and Objective. ATP-sensitive potassium (KATP) channel couples cell metabolism to excitability. To explore role of KATP channels in cellular photobiomodulation, we designed experiment to study effect of low intensity 808 nm laser irradiation on
Fu-qing Zhong, Yang Li, Xian-qiang Mi
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Membrane trafficking of ATP-sensitive potassium channels [PDF]
, 2005 ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
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Mechanical effects on KATP channel gating in rat ventricular myocytes.
PLoS ONE, 2013 Cardiac KATP channels link metabolism with electrical activity. They are implicated in arrhythmias, secretion of atrial natriuretic peptide and protection of the heart from hypertrophy and failure. These processes may involve mechanosensitivity.
Haixia Huang +6 more
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Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons [PDF]
, 2016 Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsiveness of
McCrimmon, Rory J.; id_orcid +18 more
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Zebrafish Models of KATP Channelopathies [PDF]
, 2021 Much work has been carried out to understand the composition, structure, and function of ATP-sensitive potassium (KATP) channels in mammalian tissues, as well as the molecular basis of the channelopathies that result from loss-of-function or gain-of ...
Singareddy, Soma S
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Regulation of KATP channel activity [PDF]
, 2021 ATP-sensitive potassium (KATP) channels are present in many tissues, most notably pancreatic islets and cardiac cells, where they couple the metabolic state of a cell to its electrical activity by regulating the flow of K+ across the membrane in response
Usher, Samuel
core +1 more source
eLife, 2020 Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+
Samuel G Usher +2 more
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