Results 31 to 40 of about 19,437 (170)

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Cell Reports, 2023
Summary: The ATP-sensitive K+ (KATP) channel is a key regulator of hormone secretion from pancreatic islet endocrine cells. Using direct measurements of KATP channel activity in pancreatic β cells and the lesser-studied α cells, from both humans and mice,
Thuong Ho, Evgeniy Potapenko, Dawn B. Davis, Matthew J. Merrins   +3 more
doaj   +1 more source

AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

eLife
Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as
Assmaa Elsheikh, Camden M Driggers, Ha H Truong, Zhongying Yang, John Allen, Niel M Henriksen, Katarzyna Walczewska-Szewc, Show-Ling Shyng   +7 more
doaj   +1 more source

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

Frontiers in Cellular Neuroscience, 2014
Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak, Maria S. Lemak, Oksana eVoloshanenko, Andreas eDraguhn, Andreas eDraguhn, Alexei V. Egorov, Alexei V. Egorov   +6 more
doaj   +1 more source

Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels

Frontiers in Physiology, 2022
There is strong evidence that the omega-3 polyunsaturated fatty acids (n-3 PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have cardioprotective effects.
Cristiana Bercea, Cristiana Bercea, Roshan Limbu, Kamila Behnam, Keat-Eng Ng, Qadeer Aziz, Andrew Tinker, Francesco Tamagnini, Graeme S Cottrell, Alister J McNeish   +9 more
doaj   +1 more source

ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats

International Journal of Cell Biology, 2011
ATP-sensitive potassium channels (KATP) protect the myocardium from hypertrophy induced by pressure-overloading. In this study, we determined the effects of these channels in volume-overloading.
Zikiar V. Alvin, Richard M. Millis, Wissam Hajj-Mousssa, Georges E. Haddad   +3 more
doaj   +1 more source

The Pharmacology of ATP-Sensitive K+ Channels (KATP).

, 2021
ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels thus playing an ...
Yiwen Li, Li, Y, Aziz, Q, Tinker, A, Andrew Tinker, Qadeer Aziz   +5 more
core   +1 more source

Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels

Function
The adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits, are essential for glucose homeostasis.
Athena H Li, Wen-Sheng Tsai, Wen-Hao Tsai, Shi-Bing Yang   +3 more
doaj   +1 more source

Memantine has no effect on KATP channels in pancreatic β cells

BMC Research Notes, 2018
Objective Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death.
Ryota Imai, Shingen Misaka, Shoichiro Horita, Shoko Yokota, Rie O’hashi, Yuko Maejima, Kenju Shimomura   +6 more
doaj   +1 more source

Potassium ion channels as a molecular target to reduce virus infection and mortality of honey bee colonies

Virology Journal, 2023
Declines in managed honey bee populations are multifactorial but closely associated with reduced virus immunocompetence and thus, mechanisms to enhance immune function are likely to reduce viral infection rates and increase colony viability.
Christopher J. Fellows, Michael Simone-Finstrom, Troy D. Anderson, Daniel R. Swale   +3 more
doaj   +1 more source

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

eLife, 2022
Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP ...
Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins   +11 more
doaj   +1 more source