The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development [PDF]
Frontiers in Molecular Neuroscience, 2023 Migraine is one of the leading causes of disability worldwide, affecting work and social life. It has been estimated that sales of migraine medicines will reach 12.9 billion USD in 2027.
Amalie Clement +5 more
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Identification of an ATP-sensitive potassium channel in mitochondria. [PDF]
Nature, 2019 Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood. Here we confirm the existence of a protein complex localized in mitochondria that mediates ATP-dependent potassium currents (
Paggio A +8 more
europepmc +4 more sources
Characterization of the zebrafish as a model of ATP-sensitive potassium channel hyperinsulinism [PDF]
BMJ Open Diabetes Research & CareIntroduction Congenital hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Current models to study the most common and severe form of HI resulting from inactivating mutations in the ATP-sensitive potassium channel (KATP) are
Diva D De León +2 more
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GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents [PDF]
Cardiology Research and Practice, 2019 GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning ...
Qian-Feng Xiong +8 more
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Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development [PDF]
Frontiers in ImmunologyIntroductionInvolved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to
Natalie Samper +13 more
doaj +2 more sources
Preclinical Pharmacokinetic Profile of Topical Ophthalmic and Intravenous Delivery of QLS-101, a Novel ATP-Sensitive Potassium Channel Opening Ocular Hypotensive Agent [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2023 Peter Dosa +2 more
exaly +2 more sources
Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel [PDF]
International Journal of Molecular Sciences, 2019 Adam Szewczyk +2 more
exaly +2 more sources
ATP sensitive potassium channel openers: A new class of ocular hypotensive agents [PDF]
Experimental Eye Research, 2017 Peter Dosa +2 more
exaly +2 more sources
Effects of In Vivo Intracellular ATP Modulation on Neocortical Extracellular Potassium Concentration
Biomedicines, 2022 Neuronal and glial activity are dependent on the efflux of potassium ions into the extracellular space. Efflux of K is partly energy-dependent as the activity of pumps and channels which are involved in K transportation is ATP-dependent.
Azin EbrahimAmini +2 more
doaj +1 more source
Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
doaj +1 more source