Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel [PDF]
International Journal of Molecular Sciences, 2019 An increased flux of potassium ions into the mitochondrial matrix through the ATP-sensitive potassium channel (mitoKATP) has been shown to provide protection against ischemia-reperfusion injury.
Piotr Bednarczyk +2 more
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Structure of a Pancreatic ATP-Sensitive Potassium Channel [PDF]
Cell, 2017 ATP-sensitive potassium channels ( K-ATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated extensively in a spectrum of metabolic diseases and
Ningning Li, Jing-Xiang Wu, Dian Ding
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THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL
Lancet, The, 1985 The stimulation of insulin secretion from the ß cells of the islets of Langerhans appears to be mediated by a decrease in the cell-membrane potassium-ion permeability.
Daniel L Cook, C N Hales, N C Sturgess
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Characterization of the zebrafish as a model of ATP-sensitive potassium channel hyperinsulinism [PDF]
BMJ Open Diabetes Research & CareIntroduction Congenital hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Current models to study the most common and severe form of HI resulting from inactivating mutations in the ATP-sensitive potassium channel (KATP) are
Diva D De León +2 more
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GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents [PDF]
Cardiology Research and Practice, 2019 GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning ...
Qian-Feng Xiong +8 more
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Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy. [PDF]
Methods Enzymol, 2021 ATP-sensitive potassium (K(ATP)) channels are multimeric protein complexes made of four inward rectifying potassium channel (Kir6.x) subunits and four ABC protein sulfonylurea receptor (SURx) subunits.
Driggers CM, Shyng SL.
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Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development [PDF]
Frontiers in ImmunologyIntroductionInvolved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to
Natalie Samper +13 more
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Peripheral Analgesic Effect of a Novel Curcuminoid Derivative: Possible Involvement of Peripheral Opioid Receptor and ATP-Sensitive Potassium Ion Channel [PDF]
PharmaceuticsBackground/Objectives: The present study investigated the local analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone, or BHMC, in a mouse model of peripheral nociception.
Ming Tatt Lee +6 more
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Pharmacogenomics and Personalized Medicine, 2010 Veronica Lang, Peter E LightDepartment of Pharmacology and Alberta Diabetes Institute, Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, CanadaAbstract: Neonatal diabetes mellitus (NDM)
Veronica Lang, Peter E Light
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ATP sensitive potassium channel openers: A new class of ocular hypotensive agents [PDF]
Experimental Eye Research, 2017 Uttio Roy Chowdhury +2 more
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