Results 41 to 50 of about 3,142,470 (292)
Activation of KATP channels in pain modulation: a systematic review of preclinical studies
Frontiers in PhysiologyObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich +3 more
doaj +1 more source
Anionic Phospholipids Activate ATP-sensitive Potassium Channels [PDF]
Journal of Biological Chemistry, 1997 The ATP-sensitive potassium channel (KATP) controls insulin release in pancreatic beta-cells and also modulates important functions in other cell types. In this study we report that anionic phospholipids activated KATP in pancreatic beta-cells, cardiac myocytes, skeletal muscle cells, and a cloned KATP composed of two subunits (SUR/Kir6.
Z, Fan, J C, Makielski
openaire +2 more sources
Pharmaceuticals, 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring +3 more
doaj +1 more source
PharmaceuticsBackground/Objectives: The present study investigated the local analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone, or BHMC, in a mouse model of peripheral nociception.
Ming Tatt Lee +6 more
doaj +1 more source
Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells
Journal of Diabetes Research, 2014 The aim of this study was to investigate the effects of simvastatin on insulin secretion in mouse MIN6 cells and the possible mechanism. MIN6 cells were, respectively, treated with 0 μM, 2 μM, 5 μM, and 10 μM simvastatin for 48 h.
Jieqiong Zhou +8 more
doaj +1 more source
The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]
, 2007 ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]
, 2003 The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV +4 more
core
Identification of putative potassium channel homologues in pathogenic protozoa [PDF]
, 2012 K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L +3 more
core +2 more sources
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source