Results 31 to 40 of about 3,142,470 (292)

ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential

Cells, 2022
Globally, migraine is a leading cause of disability with a huge impact on both the work and private life of affected persons. To overcome the societal migraine burden, better treatment options are needed.
Amalie Clement, Song Guo, Inger Jansen-Olesen, Sarah Louise Christensen   +3 more
doaj   +1 more source

Potassium channels in the sinoatrial node and their role in heart rate control

Channels, 2018
Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties and their role in pacemaking and ...
Qadeer Aziz, Yiwen Li, Andrew Tinker
doaj   +1 more source

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
Perciaccante, J. V., Domoki, Ferenc, Bari, Ferenc, Veltkamp, R.   +3 more
core   +2 more sources

Mechanism of resveratrol-induced relaxation in the human gallbladder

BMC Complementary and Alternative Medicine, 2017
Background Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Resveratrol produces relaxation of vascular smooth muscle and may prevent cardiovascular diseases.
Ching-Chung Tsai, Ming-Che Lee, Shu-Leei Tey, Ching-Wen Liu, Shih-Che Huang   +4 more
doaj   +1 more source

Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]

, 2000
The objective was to investigate whether myocardial adenosine triphosphate-sensitive K⁺ (K_ATP) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J., MacKenzie, I., Workman, A.J.   +2 more
core   +1 more source

ATP-sensitive potassium channel (K_ATP channel) expression in the normal canine pancreas and in canine insulinomas

BMC Veterinary Research, 2005
Background Pancreatic beta cells express ATP-sensitive potassium (KATP) channels that are needed for normal insulin secretion and are targets for drugs that modulate insulin secretion. The KATP channel is composed of two subunits: a sulfonylurea receptor
Kidder Aimee C, Hiskett Erin K, Donley Vicky R, Schermerhorn Thomas   +3 more
doaj   +1 more source

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M, Stephanou, A., Chanalaris, A., Townsend, P. A., Lawrence, K. M., Townsend, P A, Lawrence, KM, Knight, RA, Ferrari, R., Chanalaris, A, Scarabelli, T., Scarabelli, T, Hubank, M., Pasini, E., Townsend, PA, Latchman, D S, Tinker, A., Latchman, D. S., Knight, R A, Pasini, E, Comini, L, Lawrence, K M, Latchman, DS, Tinker, A, Ferrari, R, Comini, L., Knight, R. A., Stephanou, A   +27 more
core   +1 more source

ATP-Sensitive Potassium Channels in the Cerebral Circulation [PDF]

Stroke, 2003
Background— In brain blood vessels, electrophysiological studies proving the existence of ATP-sensitive potassium channels (K ATP ) are scarce. However, numerous pharmacological studies establish the importance of K ATP channels in these blood vessels ...
openaire   +2 more sources

Metabolic Control of Epilepsy: A Promising Therapeutic Target for Epilepsy

Frontiers in Neurology, 2020
Epilepsy is a common neurological disease that is not always controlled, and the ketogenic diet shows good antiepileptic effects drug-resistant epilepsy or seizures caused by specific metabolic defects via regulating the metabolism.
Yanqing Fei, Ruting Shi, Zhi Song, Jinze Wu   +3 more
doaj   +1 more source

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Alison Morrissey, Tomoe Y Nakamura, Yoshida, H, Parachuru, L, Nakamura, TY, Coetzee, WA, Lavanya Parachuru, Hidetada Yoshida, Andrew Tinker, Lanning, J, Gwendolyn Lopez, Morrissey, A, Michael Artman, William A Coetzee, Lopez, G, Tong, X, Dhar Chowdhury, P, XiaoYong Tong, Han, S, Jonathan P Giblin, Sandra Han, Giblin, JP, Erika Rosner, Jennifer Lanning, Piyali Dhar Chowdhury, Tinker, A, Rosner, E   +27 more
core   +1 more source