Results 31 to 40 of about 53,716 (302)

Nicorandil-Induced Hyperkalemia in a Uremic Patient

Case Reports in Medicine, 2012
Nicorandil is an antianginal agent with nitrate-like and ATP-sensitive potassium channel activator properties. After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...
Hung-Hao Lee, Po-Chao Hsu, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu   +4 more
doaj   +1 more source

Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell

Dose-Response, 2023
Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata, Shigeki Kitamura, Makoto Fujiwara, Masaru Shimizu, Chengbo Tan, Songji Zhao, Yuko Maejima, Kenju Shimomura   +7 more
doaj   +1 more source

ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential

Cells, 2022
Globally, migraine is a leading cause of disability with a huge impact on both the work and private life of affected persons. To overcome the societal migraine burden, better treatment options are needed.
Amalie Clement, Song Guo, Inger Jansen-Olesen, Sarah Louise Christensen   +3 more
doaj   +1 more source

Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]

, 2006
KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
Joshi, Shreena, Gurney Alison M, Prabhu Balan, Alison M Gurney, Gurney, Alyson M.; id_orcid, Balan Prabhu, Shreena Joshi, Gurney, Alison M., Joshi Shreena, Balan, Prabhu   +9 more
core   +1 more source

Mechanism of resveratrol-induced relaxation in the human gallbladder

BMC Complementary and Alternative Medicine, 2017
Background Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Resveratrol produces relaxation of vascular smooth muscle and may prevent cardiovascular diseases.
Ching-Chung Tsai, Ming-Che Lee, Shu-Leei Tey, Ching-Wen Liu, Shih-Che Huang   +4 more
doaj   +1 more source

Identification of putative potassium channel homologues in pathogenic protozoa [PDF]

, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L, Neil V Marrion, Marrion, NV, David L Prole   +3 more
core   +1 more source

ATP-sensitive potassium channel (K_ATP channel) expression in the normal canine pancreas and in canine insulinomas

BMC Veterinary Research, 2005
Background Pancreatic beta cells express ATP-sensitive potassium (KATP) channels that are needed for normal insulin secretion and are targets for drugs that modulate insulin secretion. The KATP channel is composed of two subunits: a sulfonylurea receptor
Kidder Aimee C, Hiskett Erin K, Donley Vicky R, Schermerhorn Thomas   +3 more
doaj   +1 more source

The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]

, 2009
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F., Puja R. Mehta, Sutcliffe, M. J., M. J. Sutcliffe, Mehta, Puja R., Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Feng, J.F., Sutcliffe, M.J., Vavoulis, Dimitris V., Mehta, Puja, R., Vavoulis, D. V., Ashmole, I., Stansfeld, P.J., Feng, Jianfeng, Stansfeld, Phillip J., I. Ashmole, J. F. Feng, P. J. Stansfeld, Vavoulis, D.V., D. V. Vavoulis, P. R. Stanfield, Stanfield, P.R.   +23 more
core   +1 more source

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]

, 2007
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J., M. J. Sutcliffe, Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Yuill, K. H., Ashmole, I., Yuill, K.H., Stansfeld, P.J., Stansfeld, Phillip J., I. Ashmole, P. J. Stansfeld, K. H. Yuill, P. R. Stanfield, Stanfield, P.R.   +14 more
core   +1 more source

CO2-dependent opening of an inwardly rectifying K+ channel [PDF]

, 2011
CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Dale, Nicholas, Robert T. R. Huckstepp, Huckstepp, Robert T. R., Nicholas Dale   +3 more
core   +1 more source