Results 21 to 30 of about 3,142,470 (292)
Endothelial biology and ATP-sensitive potassium channels [PDF]
Channels, 2018 ATP sensitive potassium (KATP) channels are metabolic sensors with channel activity promoted by decreases in ATP and\or increases in MgADP.
Aziz, Q, Li, Y, Tinker, A
openaire +3 more sources
Бюллетень сибирской медицины, 2017 The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with ...
S. N. Orlov +9 more
doaj +1 more source
ATP-sensitive K(+)-channels in muscle cells: features and physiological role [PDF]
The Ukrainian Biochemical Journal, 2014 ATP-sensitive K+-channels of plasma membranes belong to the inward rectifier potassium channels type. They are involved in coupling of electrical activity of muscle cell with its metabolic state.
O. B. Vadzyuk
doaj +1 more source
Inhibition of ATP‐sensitive potassium channels by haloperidol [PDF]
British Journal of Pharmacology, 2004 Chronic haloperidol treatment has been associated with an increased incidence of glucose intolerance and type‐II diabetes mellitus. We studied the effects of haloperidol on native ATP‐sensitive potassium (KATP) channels in mouse pancreatic β cells and on cloned Kir6.2/SUR1 channels expressed in HEK293 cells.
Yang, S +3 more
openaire +3 more sources
A KATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]
, 2001 Low concentrations of certain K<sub>ATP</sub> channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
Northover, B.J. +5 more
core +1 more source
ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity [PDF]
Diabetes & Metabolism Journal, 2011 BackgroundThe hypothalamus, the center for body weight regulation, can sense changes in blood glucose level based on ATP-sensitive potassium (KATP) channels in the hypothalamic neurons.
Yeul Bum Park +7 more
doaj +1 more source
Intractable hyperkalemia due to nicorandil induced potassium channel syndrome
Annals of Cardiac Anaesthesia, 2015 Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space
Vivek Chowdhry, B B Mohanty
doaj +1 more source
Anaesthetic phencyclidine, blocker of the ATP‐sensitive potassium channels [PDF]
FEBS Letters, 1994 The double sucrose gap and patch‐clamp studies revealed that phencyclidine blocked the ATP‐sensitive K+ channel in isolated cardiac cells (half‐maximal inhibition at ≈20 μM; Hill coefficient ≈1). 10μM phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae.
Kokoz, Yuri M. +4 more
openaire +2 more sources
Nicorandil-Induced Hyperkalemia in a Uremic Patient
Case Reports in Medicine, 2012 Nicorandil is an antianginal agent with nitrate-like and ATP-sensitive potassium channel activator properties. After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...
Hung-Hao Lee +4 more
doaj +1 more source
Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell
Dose-Response, 2023 Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata +7 more
doaj +1 more source