Identification of an ATP-sensitive potassium channel in mitochondria. [PDF]
Nature, 2019 Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood. Here we confirm the existence of a protein complex localized in mitochondria that mediates ATP-dependent potassium currents (
Paggio A +8 more
europepmc +4 more sources
Regulation of cholecystokinin secretion by ATP-sensitive potassium channels
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1994 The relationship of potassium channel activity to the secretion of cholecystokinin (CCK) was evaluated in STC-1 cells, an intestinal CCK-secreting cell line.
S. Basavappa +6 more
core +3 more sources
Effects of In Vivo Intracellular ATP Modulation on Neocortical Extracellular Potassium Concentration
Biomedicines, 2022 Neuronal and glial activity are dependent on the efflux of potassium ions into the extracellular space. Efflux of K is partly energy-dependent as the activity of pumps and channels which are involved in K transportation is ATP-dependent.
Azin EbrahimAmini +2 more
doaj +1 more source
Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
doaj +1 more source
Mitochondria from rat uterine smooth muscle possess ATP-sensitive potassium channel [PDF]
Saudi Journal of Biological Sciences, 2018 Vadzyuk OB, Kosterin SO.
exaly +2 more sources
The role of potassium channels and calcium in the relaxation mechanism of magnesium sulfate on the isolated rat uterus [PDF]
Archives of Biological Sciences, 2019 MgSO4 is used as a tocolytic agent. It is considered to be a calcium channel antagonist, but a different mechanism of its action might be involved. The aim of this study was to examine the contribution of calcium concentrations and potassium channels in ...
Sokolović Dragana +6 more
doaj +1 more source
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects
Frontiers in Pharmacology, 2022 Bisphosphonates (BPs) are the most used bone-specific anti-resorptive agents, often chosen as first-line therapy in several bone diseases characterized by an imbalance between osteoblast-mediated bone production and osteoclast-mediated bone resorption ...
Rosa Scala +11 more
doaj +1 more source
Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases
Frontiers in Physiology, 2022 Astrocytes play an important role in the central nervous system (CNS). Ion channels in these cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but also participate in physiological processes of neurons and glial ...
Sijian Wang +5 more
doaj +1 more source
ATP-sensitive potassium channels and vascular function [PDF]
Channels, 2015 ATP-sensitive potassium channels (KATP) are widely distributed in different organs of the body. They are best described in pancreatic β cells and cardiac myocytes but are also present in the periph...
Qadeer, Aziz, Yiwen, Li, Andrew, Tinker
openaire +2 more sources
Inhibition of ATP‐sensitive potassium channels by haloperidol [PDF]
British Journal of Pharmacology, 2004 Chronic haloperidol treatment has been associated with an increased incidence of glucose intolerance and type‐II diabetes mellitus. We studied the effects of haloperidol on native ATP‐sensitive potassium (KATP) channels in mouse pancreatic β cells and on cloned Kir6.2/SUR1 channels expressed in HEK293 cells.
Yang, S +3 more
openaire +3 more sources