Results 1 to 10 of about 7,411 (220)

Efficacy of glyburide vs. metformin in preventing neonatal birth obesity in pregnancies complicated by gestational diabetes mellitus: a systematic review and meta-analysis [PDF]

Frontiers in Pediatrics
BackgroundGestational diabetes mellitus (GDM) has significant implications for both maternal and fetal health, increasing the risk of macrosomia, neonatal hypoglycemia, and long-term metabolic complications in offspring.
Wan Jiang, Hongli Zhang, Xin Liu, Jianglan Xie, Jian Liu   +4 more
doaj   +4 more sources

¹¹ C-glyburide PET imaging unveils the negligible brain penetration of glyburide in humans [PDF]

Neurology, 2019
Kimberly and coworkers reported the beneficial effects of intravenous glyburide on the clinical outcome of brain edema. We developed the carbon-11 radiolabeled analogue of glyburide to study the body distribution of this compound using PET imaging.
Solène Marie, Claude Comtat, Fabien Caillé, Laurent Becquemont, Michel Bottlaender, Nicolas Tournier   +5 more
openaire   +6 more sources

Comparative safety of sulfonylurea therapies on cardiovascular and severe hypoglycemia outcomes among adults with type 2 diabetes and moderate cardiovascular risk: a target trial emulation [PDF]

BMJ Open Diabetes Research & Care
Introduction To examine within-class sulfonylurea safety, we compared risks of major adverse cardiovascular events (MACE) and severe hypoglycemia among adults with type 2 diabetes (T2D) and moderate cardiovascular risk following sulfonylurea initiation ...
Guillermo E Umpierrez, Rodolfo J Galindo, Jeph Herrin, Juan P Brito, Joseph S Ross, Víctor M Montori, Rozalina Grubina McCoy, Eric C Polley, Bradley A Maron, Alexandria A Ratzki-Leewing, Yihong Deng, Stacey Sklepinski, Kavya Sindhu Swarna, Joshua J Neumiller, Bijan J Borah, Mindy M Mickelson   +15 more
doaj   +2 more sources

Comparative effectiveness of sulfonylureas on kidney outcomes in adults with type 2 diabetes and moderate cardiovascular risk: a target trial emulation [PDF]

BMJ Open Diabetes Research & Care
Introduction To assess the within-class variation in kidney outcomes following initiation of sulfonylurea therapy.Research design and methods We used claims data of enrollees in commercial, Medicare Advantage, and traditional Medicare health plans ...
Guillermo E Umpierrez, Rodolfo J Galindo, Jeph Herrin, Juan P Brito, Joseph S Ross, Víctor M Montori, Rozalina Grubina McCoy, Eric C Polley, Alexandria A Ratzki-Leewing, Yihong Deng, Stacey Sklepinski, Kavya Sindhu Swarna, Joshua J Neumiller, Mindy M Mickelson   +13 more
doaj   +2 more sources

Maternal-to-Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines. [PDF]

Clin Pharmacol Ther
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Richardson K, Kiptoo J, Mpora Odongkara B, Ojara FW, Waitt C.   +4 more
europepmc   +2 more sources

Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury [PDF]

PeerJ, 2018
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans.
Nick Jeffery, C. Elizabeth Boudreau, Megan Konarik, Travis Mays, Virginia Fajt   +4 more
doaj   +3 more sources

Virtual Bioequivalence Assessment and Dissolution Safe Space Exploration for Fixed-Dose Metformin–Glyburide Tablet Using Physiologically Based Biopharmaceutics Modeling [PDF]

Pharmaceutics
Background/Objectives: Fixed-dose combinations (FDCs) hold significant clinical value for the management of hypertension, diabetes and other chronic diseases.
Chenshuang Zhao, Chaozhuang Shen, Yumeng Xiao, Ling Wang   +3 more
doaj   +2 more sources

Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis [PDF]

BMC Endocrine Disorders, 2021
Aims We aimed to assess the comparative efficiency and safety of the use of glyburide, metformin, and insulin in gestational diabetes mellitus (GDM). Methods We searched for randomized controlled trials that compared glyburide, metformin, and insulin in ...
Dan-Qing Yu, Guan-Xin Xu, Xin-Yuan Teng, Jing-Wei Xu, Liang-Fang Tang, Chun Feng, Jin-Peng Rao, Min Jin, Li-Quan Wang   +8 more
doaj   +2 more sources

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide

Journal of Lipid Research, 2004
Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a receptor that binds HDL with high affinity and mediates both the selective lipid uptake of cholesteryl
Thomas J.F. Nieland, Angeliki Chroni, Michael L. Fitzgerald, Zoltan Maliga, Vassilis I. Zannis, Tomas Kirchhausen, Monty Krieger   +6 more
doaj   +2 more sources

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

The Journal of Experimental Medicine, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1β (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns (DAMPs), and crystals.
Lamkanfi, Mohamed, Mueller, JL, Vitari, AC, Misaghi, S, Fedorova, A, Deshayes, K, Lee, WP, Hoffman, HM, Dixit, VM   +8 more
openaire   +6 more sources