Results 1 to 10 of about 6,498 (133)

Comparative safety of sulfonylurea therapies on cardiovascular and severe hypoglycemia outcomes among adults with type 2 diabetes and moderate cardiovascular risk: a target trial emulation [PDF]

BMJ Open Diabetes Research & Care
Introduction To examine within-class sulfonylurea safety, we compared risks of major adverse cardiovascular events (MACE) and severe hypoglycemia among adults with type 2 diabetes (T2D) and moderate cardiovascular risk following sulfonylurea initiation ...
Guillermo E Umpierrez, Rodolfo J Galindo, Jeph Herrin, Juan P Brito, Joseph S Ross, Víctor M Montori, Rozalina Grubina McCoy, Eric C Polley, Bradley A Maron, Alexandria A Ratzki-Leewing, Yihong Deng, Stacey Sklepinski, Kavya Sindhu Swarna, Joshua J Neumiller, Bijan J Borah, Mindy M Mickelson   +15 more
doaj   +2 more sources

Comparative effectiveness of sulfonylureas on kidney outcomes in adults with type 2 diabetes and moderate cardiovascular risk: a target trial emulation [PDF]

BMJ Open Diabetes Research & Care
Introduction To assess the within-class variation in kidney outcomes following initiation of sulfonylurea therapy.Research design and methods We used claims data of enrollees in commercial, Medicare Advantage, and traditional Medicare health plans ...
Guillermo E Umpierrez, Rodolfo J Galindo, Jeph Herrin, Juan P Brito, Joseph S Ross, Víctor M Montori, Rozalina Grubina McCoy, Eric C Polley, Alexandria A Ratzki-Leewing, Yihong Deng, Stacey Sklepinski, Kavya Sindhu Swarna, Joshua J Neumiller, Mindy M Mickelson   +13 more
doaj   +2 more sources

Efficacy of glyburide vs. metformin in preventing neonatal birth obesity in pregnancies complicated by gestational diabetes mellitus: a systematic review and meta-analysis [PDF]

Frontiers in Pediatrics
BackgroundGestational diabetes mellitus (GDM) has significant implications for both maternal and fetal health, increasing the risk of macrosomia, neonatal hypoglycemia, and long-term metabolic complications in offspring.
Wan Jiang, Hongli Zhang, Xin Liu, Jianglan Xie, Jian Liu   +4 more
doaj   +2 more sources

Virtual Bioequivalence Assessment and Dissolution Safe Space Exploration for Fixed-Dose Metformin–Glyburide Tablet Using Physiologically Based Biopharmaceutics Modeling [PDF]

Pharmaceutics
Background/Objectives: Fixed-dose combinations (FDCs) hold significant clinical value for the management of hypertension, diabetes and other chronic diseases.
Chenshuang Zhao, Chaozhuang Shen, Yumeng Xiao, Ling Wang   +3 more
doaj   +2 more sources

How the First 9 Months Shape the Rest of Your Life: The Impact of Gestational Diabetes on the Metabolic Future. [PDF]

Diabetes Obes Metab
ABSTRACT Gestational diabetes mellitus (GDM) represents far more than a transient glycaemic disorder: it is a sentinel metabolic event that unveils pre‐existing defects in β‐cell function and insulin action, with profound implications for both maternal and offspring cardiometabolic health across the lifespan.
Kanat M, Abdul-Ghani M, DeFronzo RA.
europepmc   +2 more sources

Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure [PDF]

Acta Pharmaceutica Sinica B
Organic anion-transporting polypeptides (OATP) transporter function, which mediates many drugs' liver uptake, was investigated as a molecular determinant of pharmacokinetic variability.
Solène Marie, Anne-Lise Lecoq, Louise Breuil, Fabien Caillé, Vincent Lebon, Claude Comtat, Sébastien Goutal, Laurent Becquemont, Michel Bottlaender, Céline Verstuyft, Nicolas Tournier   +10 more
doaj   +2 more sources

Glyburide reduces bacterial dissemination in a mouse model of melioidosis. [PDF]

PLoS Neglected Tropical Diseases, 2013
Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ~40% mortality rate despite antimicrobial chemotherapy. We showed in a previous cohort
Gavin C K W Koh, Tassili A Weehuizen, Katrin Breitbach, Kathrin Krause, Hanna K de Jong, Liesbeth M Kager, Arjan J Hoogendijk, Antje Bast, Sharon J Peacock, Tom van der Poll, Ivo Steinmetz, W Joost Wiersinga   +11 more
doaj   +1 more source

Aspalathin-rich green rooibos tea in combination with glyburide and atorvastatin enhances lipid metabolism in a db/db mouse model

Frontiers in Clinical Diabetes and Healthcare, 2022
Rooibos (Aspalathus linearis), an indigenous South African plant and its major flavonoid, aspalathin, exhibited positive effects on glycemia and dyslipidemia in animal studies.
Oelfah Patel, Oelfah Patel, Christo J. F. Muller, Christo J. F. Muller, Christo J. F. Muller, Elizabeth Joubert, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Johan Louw, Charles Awortwe, Charles Awortwe   +11 more
doaj   +1 more source

Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury [PDF]

PeerJ, 2018
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans.
Nick Jeffery, C. Elizabeth Boudreau, Megan Konarik, Travis Mays, Virginia Fajt   +4 more
doaj   +2 more sources

Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk.

PLoS ONE, 2020
BackgroundIn pregnant women with gestational diabetes, glyburide can be an alternative to insulin despite concerns about its transplacental transfer. However, transplacental transfer of glyburide is poorly quantified and the relationship between cord ...
Hanane Bouchghoul, Jean-Claude Alvarez, Céline Verstuyft, Jean Bouyer, Marie-Victoire Senat   +4 more
doaj   +1 more source