Results 11 to 20 of about 7,638 (174)

Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date

Drug Design, Development and Therapy, 2018
Zachary A King,1 Kevin N Sheth,1 W Taylor Kimberly,2 J Marc Simard3 1Department of Neurology, Division of Neurocritical Care and Emergency Neurology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Neurology, Division of ...
King ZA, Sheth KN, Kimberly WT, Simard JM   +3 more
doaj   +1 more source

Efficacy and safety of hypoglycemic agents on gestational diabetes mellitus in women: A Bayesian network analysis of randomized controlled trials

Frontiers in Public Health, 2022
ObjectiveTo compare the efficacy and safety of metformin, glyburide, and insulin for GDM, we conducted a subgroup analysis of outcomes for women with GDM according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG ...
Ting Wang, Ting Wang, Yingyu Jing, Haonan Guo, Jing Xu, Man Wang, Lili Huang, Huan Chen, Wei Cui, Lin Song, Xiang Liu, Bo Sun, Ning Wang, Ning Wang   +13 more
doaj   +1 more source

Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade

iScience, 2020
Summary: Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity.
Yan Qiu, Yuanyuan Yang, Yuda Wei, Xiaojian Liu, Zhuanghui Feng, Xuwen Zeng, Yanhao Chen, Yan Liu, Yongxu Zhao, Lanlan Chen, Lijun Luo, Qiurong Ding   +11 more
doaj   +1 more source

Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis

Journal of Family Medicine and Primary Care, 2022
The safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin ...
Mandar K Shah, Mihika A Shah, Sharan D Shah, Parshwa K Shah, Kaushal Patel, Mamta Gupta   +5 more
doaj   +1 more source

Long-Term Oral Treatment with Non-Hypoglycemic Dose of Glibenclamide Reduces Diabetic Retinopathy Damage in the Goto-KakizakiRat Model

Pharmaceutics, 2021
Diabetic retinopathy (DR) remains a major cause of vision loss, due to macular edema, retinal ischemia and death of retinal neurons. We previously demonstrated that acute administration of glibenclamide into the vitreous, or given orally at a non ...
Marianne Berdugo, Kimberley Delaunay, Cécile Lebon, Marie-Christine Naud, Lolita Radet, Léa Zennaro, Emilie Picard, Alejandra Daruich, Jacques Beltrand, Elsa Kermorvant-Duchemin, Michel Polak, Patricia Crisanti, Francine F. Behar-Cohen   +12 more
doaj   +1 more source

Inhibition of SUR1 Decreases the Vascular Permeability of Cerebral Metastases

Neoplasia: An International Journal for Oncology Research, 2013
Inhibition of sulfonylurea receptor 1 (SUR1) by glyburide has been shown to decrease edema after subarachnoid hemorrhage. We investigated if inhibiting SUR1 reduces cerebral edema due to metastases, the most common brain tumor, and explored the putative ...
Eric M Thompson, Gregory L Pishko, Leslie L Muldoon, Edward A Neuwelt   +3 more
doaj   +1 more source

A case of glyburide-induced leukocytoclastic vasculitis [PDF]

, 2013
Introduction: Medication-induced leukocytoclastic vasculitis is a small-vessel vasculitis that most commonly manifests with palpable purpuric lesions on gravity dependent areas.
Fraga, Garth R, Blackmon, Joseph A, Rajpara, Anand, Maz, Mehrdad, Henley, Jill K   +4 more
core   +1 more source

Effect of Glyburide—Metformin Combination Tablet in Patients with Type 2 Diabetes [PDF]

, 2007
BackgroundTo evaluate the efficacy and safety of glyburide/metformin combined tablet compared to glyburide or metformin alone in patients with type 2 diabetes.MethodsIn this 16-week, multicenter, randomized, double-blind, 4-arm and parallel clinical ...
Chang, Chwen-Tzuei, Lee, I-Te, Hsieh, Sheng-Hwu, Sheu, Wayne H.H., Chu, Nain-Feng, Tang, Yih-Jing, Lee, Wen-Jane, Chien, Hsin-Hsi, Huang, Yu-Yao   +8 more
core   +1 more source

Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis.

PLoS ONE, 2017
ObjectiveThe aim of this meta-analysis was to determine the efficacy and safety of glyburide as a treatment for gestational diabetes mellitus (GDM) compared to insulin.MethodsA meta-analysis was conducted to compare the management of gestational diabetes
Rongjing Song, Ling Chen, Yue Chen, Xia Si, Yi Liu, Yue Liu, David M Irwin, Wanyu Feng   +7 more
doaj   +1 more source

The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

Frontiers in Physiology, 2021
BackgroundCalcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (KATP) channels. Here, we investigated the effect of the KATP channel
Hande Coskun, Fatima Azzahra Elbahi, Fatima Azzahra Elbahi, Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Majid Sheykhzade, Messoud Ashina, Messoud Ashina   +7 more
doaj   +1 more source