Results 11 to 20 of about 7,411 (220)

Transfer of Glyburide and Glipizide Into Breast Milk [PDF]

Obstetrical & Gynecological Survey, 2005
OBJECTIVE—To determine if glyburide and glipizide are excreted into breast milk and if breast-feeding from women taking these drugs causes infant hypoglycemia. RESEARCH DESIGN AND METHODS—We studied eight women who had received a single oral dose of 5 or 10 mg glyburide.
Denice S, Feig, Gerald G, Briggs, Jennifer M, Kraemer, Peter J, Ambrose, David N, Moskovitz, Michael, Nageotte, Diane J, Donat, Guadalupe, Padilla, Stephanie, Wan, Julia, Klein, Gideon, Koren   +10 more
openaire   +4 more sources

Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure [PDF]

Acta Pharmaceutica Sinica B
Organic anion-transporting polypeptides (OATP) transporter function, which mediates many drugs' liver uptake, was investigated as a molecular determinant of pharmacokinetic variability.
Solène Marie, Anne-Lise Lecoq, Louise Breuil, Fabien Caillé, Vincent Lebon, Claude Comtat, Sébastien Goutal, Laurent Becquemont, Michel Bottlaender, Céline Verstuyft, Nicolas Tournier   +10 more
doaj   +2 more sources

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma [PDF]

Nature Communications
Glioblastoma multiforme (GBM) remains a therapeutic challenge due to its aggressive nature and recurrence. This study establishes a radioresistant GBM cell model through repeated irradiation and observes a cellular senescence-like phenotype in these ...
Yuchuan Zhou, Liang Zeng, Linbo Cai, Wang Zheng, Xinglong Liu, Yuqi Xiao, Xiaoya Jin, Yang Bai, Mingyao Lai, Hainan Li, Hua Jiang, Songling Hu, Yan Pan, Jianghong Zhang, Chunlin Shao   +14 more
doaj   +2 more sources

Modeling Whole-Body Dynamic PET Microdosing Data to Predict the Whole-Body Pharmacokinetics of Glyburide in Humans. [PDF]

Clin Pharmacokinet
Comin L, Marie S, Ursino M, Zohar S, Tournier N, Comets E.   +5 more
europepmc   +3 more sources

Glyburide reduces bacterial dissemination in a mouse model of melioidosis. [PDF]

PLoS Neglected Tropical Diseases, 2013
Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ~40% mortality rate despite antimicrobial chemotherapy. We showed in a previous cohort
Gavin C K W Koh, Tassili A Weehuizen, Katrin Breitbach, Kathrin Krause, Hanna K de Jong, Liesbeth M Kager, Arjan J Hoogendijk, Antje Bast, Sharon J Peacock, Tom van der Poll, Ivo Steinmetz, W Joost Wiersinga   +11 more
doaj   +1 more source

Aspalathin-rich green rooibos tea in combination with glyburide and atorvastatin enhances lipid metabolism in a db/db mouse model

Frontiers in Clinical Diabetes and Healthcare, 2022
Rooibos (Aspalathus linearis), an indigenous South African plant and its major flavonoid, aspalathin, exhibited positive effects on glycemia and dyslipidemia in animal studies.
Oelfah Patel, Oelfah Patel, Christo J. F. Muller, Christo J. F. Muller, Christo J. F. Muller, Elizabeth Joubert, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Johan Louw, Charles Awortwe, Charles Awortwe   +11 more
doaj   +1 more source

Glyburide

, 2006
europepmc   +2 more sources

Safety and Effectiveness of Oral Glyburide Suspension in Neonatal Diabetes Mellitus: French Retrospective Cohort Study. [PDF]

J Endocr Soc
Ben Rhaiem I, Beltrand J, Vermillac G, Kariyawasam D, Geraud D, Besançon A, Godot C, Berdugo M, Bonnard AA, Cavé H, Nivot-Adamiak S, Saade MB, Ribault V, Baron S, Petit-Bibal C, Dalla-Vale F, Bourdet K, Morin C, Donzeau A, Gueorguieva I, Souchon PF, Nicolino M, Barat P, Coutant R, Perge K, Polak M.   +25 more
europepmc   +3 more sources

Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk.

PLoS ONE, 2020
BackgroundIn pregnant women with gestational diabetes, glyburide can be an alternative to insulin despite concerns about its transplacental transfer. However, transplacental transfer of glyburide is poorly quantified and the relationship between cord ...
Hanane Bouchghoul, Jean-Claude Alvarez, Céline Verstuyft, Jean Bouyer, Marie-Victoire Senat   +4 more
doaj   +1 more source

Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade

iScience, 2020
Summary: Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity.
Yan Qiu, Yuanyuan Yang, Yuda Wei, Xiaojian Liu, Zhuanghui Feng, Xuwen Zeng, Yanhao Chen, Yan Liu, Yongxu Zhao, Lanlan Chen, Lijun Luo, Qiurong Ding   +11 more
doaj   +1 more source