Results 41 to 50 of about 7,638 (174)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Wyne P. Lee, Fedorova, A, Vishva M. Dixit, Vitari, AC, Anna Fedorova, Mueller, JL, Lee, WP, Hal M. Hoffman, Dixit, VM, James L. Mueller, Shahram Misaghi, Alberto C. Vitari, Deshayes, K, Mohamed Lamkanfi, Misaghi, S, Hoffman, HM, Kurt Deshayes, Lamkanfi, Mohamed   +17 more
core   +1 more source

An anti-inflammatory Glyburide-loaded nanoghost for atherosclerosis therapy: A red blood cell based bio-mimetic strategy

Giant, 2023
Inflammation control is becoming a critical strategy for atherosclerosis management, because inflammation is involved in plaque progression. In this regard, a biomimetic strategy using cell membrane-coated nanoparticles has some promising advantages.
Zahra Karami, Mohammad Akrami, Jalil Mehrzad, Mehdi Esfandyari-Manesh, Ismaeil Haririan, Saeid Nateghi   +5 more
doaj   +1 more source

Stretching Scarce Authorizing Legislation as Far as Possible: A Legislative History of the 340B Drug Pricing Program

The Milbank Quarterly, EarlyView.
Policy Points The original purpose of the 340B program was to exempt Public Health Service Act funded clinics and state and local public hospitals from the inflationary best‐price component of the recently enacted Medicaid drug rebate program. The secondary purpose was to reduce drug prices for these clinics and hospitals in order to preserve and ...
SAYEH NIKPAY, MIKAYLA REINKE, NICOLE QUINONES   +2 more
wiley   +1 more source

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide

Journal of Lipid Research, 2004
Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a receptor that binds HDL with high affinity and mediates both the selective lipid uptake of cholesteryl
Thomas J.F. Nieland, Angeliki Chroni, Michael L. Fitzgerald, Zoltan Maliga, Vassilis I. Zannis, Tomas Kirchhausen, Monty Krieger   +6 more
doaj   +1 more source

Antenatal Corticosteroids in Gestational Diabetes: A Systematic Review of Glycemic Response and Management Strategies

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Antenatal corticosteroids (ACS) promote foetal lung maturation in pregnancies at risk of preterm birth; however, in gestational diabetes mellitus (GDM), they can exacerbate maternal glycemia and contribute to adverse neonatal outcomes. Clinical guidelines offer limited direction on optimal treatment adjustment.
Alexandra Katz, Aidan Shulkin, Samantha Jacobson, Chella Price, Michael A. Tsoukas, Isabella Albanese, Agnieszka Majdan, Jill Pancer, Ariane Godbout, Kaberi Dasgupta, Anne‐Sophie Brazeau, Tricia Peters   +11 more
wiley   +1 more source

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

, 2006
BACKGROUND: The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known.
Jones, N, Heise, M, Viberti, G, G. VIBERTI, Kahn, S, RR HOLMAN NJ JONES, Lachin, J, Holman, RR, Kahn, SE, B. ZINMANN, Kravitz, B, Holman, Rury, Study Group, ADOPT, O'Neill, M C, JM LACHIN, Zinman, B, MA HEISE, Herman, WH, Jones, NP, Herman, W, Heise, MA, Holman, R, SM HAFFNER, KAHN SE, O'Neill, MC, Lachin, JM, Haffner, SM, BG KRAVITZ, Kravitz, BG, GALLUZZO, Aldo, WH HERMAN, MCOLLEEN O'NEILL, Haffner, S   +32 more
core   +1 more source

Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta‐analyses and network meta‐analysis

Journal of Diabetes Investigation, 2021
Aims/Introduction Despite there being several meta‐analyses on the effects of antidiabetic agents in patients with gestational diabetes mellitus, the reliability of their findings is a concern, mainly due to undetermined methodological quality of these ...
Razieh Bidhendi Yarandi, Mina Amiri, Fahimeh Ramezani Tehrani, Samira Behboudi‐Gandevani   +3 more
doaj   +1 more source

Characteristics of studies comparing glyburide and insulin.

, 2014
Yrs.: Years.*Percentage of patients requiring insulin therapy in glyburide group. NA: Not available. BMI: Body mass index. F: Fasting.**Mean BMI≥27.3 was observed in 67% of subjects included in the study.#Only women with FPG≥9530.Characteristics of ...
Muhammad Amin (169590), Naeti Suksomboon (524350), Nalinee Poolsup (524351)   +2 more
core   +1 more source

Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus [PDF]

, 2020
In gestational diabetes mellitus (GDM), women are unable to compensate for the increased insulin resistance during pregnancy. Data are limited regarding the pharmacodynamic effects of metformin and glyburide during pregnancy.
Haneline, L.S., Thummel, K.E., Shireman, L.M., Clark, S., Haas, D.M., Brown, L.M., Manuck, T.A., Shuster, D.L., Ma, X., Brown, Z., Caritis, S., Tita, A.T., Ren, Z., Ahmed, M.S., Flood Nichols, S.K., Quinney, S.K., Easterling, T.R., Hebert, M.F., Shen, D.D., Venkataramanan, R.   +19 more
core   +1 more source