Results 61 to 70 of about 7,411 (220)

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Antidiabetic evaluation of vanillic acid-glyburide loaded polymeric micelles in high fat diet and streptozotocin induced diabetic rats [PDF]

, 2023
Jaskiran Kaur, Monica Gulati, Narendra Kumar Pandey, Gopal L. Khatik, Swathi Sudhakar, Faisal Alotaibi, Deepak Kumar, Monu Kumar Shukla, Parveen Kumar, Paras Famta, Poonam Arora, Kunle Okaiyeto, Oluwafemi Omoniyi Oguntibeju, Gaurav Gupta, Keshav Raj Paudel, Kamal Dua, Sachin Kumar Singh   +16 more
openalex   +1 more source

Evaluation of Potentially Inappropriate Medications Prescribed to Older Adults Upon Emergency Department Discharge

Academic Emergency Medicine, Volume 33, Issue 3, March 2026.
ABSTRACT Background Older adults are susceptible to adverse drug effects due to age‐related changes, a higher prevalence of comorbidities, and complexities in medication management. Nearly half of geriatric patients are prescribed at least one new medication at ED discharge.
Jessica Schowe, Andrew M. North, Kyle Schuchter, Katherine M. Hunold, Elizabeth Rozycki   +4 more
wiley   +1 more source

Beyond evidence hierarchies: Leveraging randomized controlled trials and real‐world data to advance the value of maternity care

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 3, Page 395-402, March 2026.
Value‐based maternity care decisions should draw on cost‐effectiveness evidence from both randomized controlled trials and real‐world data, integrating them systematically rather than ranking them hierarchically. Abstract While existing literature has compared the methodological strengths and limitations of randomized controlled trials (RCTs) and real ...
Yanan Hu, Valerie Slavin, Joanne Enticott, Emily Callander   +3 more
wiley   +1 more source

Genetic Analysis and Follow-Up of 25 Neonatal Diabetes Mellitus Patients in China

Journal of Diabetes Research, 2016
Aims. To study the clinical features, genetic etiology, and the correlation between phenotype and genotype of neonatal diabetes mellitus (NDM) in Chinese patients. Methods.
Bingyan Cao, Chunxiu Gong, Di Wu, Chaoxia Lu, Fang Liu, Xiaojing Liu, Yingxian Zhang, Yi Gu, Zhan Qi, Xiaoqiao Li, Min Liu, Wenjing Li, Chang Su, Xuejun Liang, Mei Feng   +14 more
doaj   +1 more source

Short-term high-fat diet (HFD) induced anxiety-like behaviors and cognitive impairment are improved with treatment by glyburide

Frontiers in Behavioral Neuroscience, 2016
Obesity-associated comorbidities such as cognitive impairment and anxiety are an increasing public health burden that has gained prevalence in children. To better understand the impact of childhood obesity on brain function, mice were fed a high-fat diet
Stephen Gainey, Stephen Gainey, Kristin Kwakwa, Julie Bray, Melissa Pillote, Vincent Tir, Albert Towers, Albert Towers, Gregory Freund, Gregory Freund, Gregory Freund   +10 more
doaj   +1 more source

Loss of Beta‐Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes

MedComm, Volume 7, Issue 2, February 2026.
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Sumit Patel, Zihan Yan, Maria S. Remedi
wiley   +1 more source

Associations of modifiable preconception, pregnancy and postpartum factors with health outcomes for women with type 2 diabetes and their children: A systematic review and meta‐analysis of observational studies

Diabetic Medicine, Volume 43, Issue 2, February 2026.
Abstract Aim Type 2 diabetes (T2D) in pregnancy is increasingly common and associated with suboptimal outcomes for these women and their children. We aimed to synthesize observational evidence on associations of modifiable preconception, pregnancy and postpartum risk factors with perinatal outcomes among women with pregestational T2D.
Danielle Schoenaker, Eleanor Dyer, Nicola Heslehurst, Grainne Kent, Sowmiya Gunabalasingam, Lily Hopkins, Artemis Kyrka, Rivka Lebrett, Angela C. Flynn, Sara L. White, Claire L. Meek, Rita Forde   +11 more
wiley   +1 more source

Tratamento do diabetes mellitus gestacional com glibenclamida: fatores de sucesso e resultados perinatais Gestational diabetes mellitus management with glyburide: factors of success and perinatal outcomes

Revista Brasileira de Ginecologia e Obstetrícia, 2007
OBJETIVO: identificar os fatores relacionados ao sucesso no tratamento do diabetes mellitus gestacional (DMG) com a glibenclamida e avaliar os resultados perinatais. MÉTODOS: estudo longitudinal, prospectivo, no qual foram incluídas, no período de agosto
Jean Carl Silva, Amanda Heinen, Mariana Benedet Scheidt, Marina Abreu de Oliveira Marcondes, Anna Maria Bertini   +4 more
doaj   +1 more source

Comparison of Glyburide and Insulin In Women with Gestational Diabetes Mellitus and Associated Perinatal Outcome: a Randomized Clinical Trial

Acta Medica Iranica, 2015
Insulin is currently the drug of choice in treating patients with gestational diabetes mellitus but insulin is expensive, inconvenient to store and use and probably associated with more risks of asymptomatic hypoglycemia in comparison with some oral ...
Masoomeh Mirzamoradi, Zahra Heidar, Ziba Faalpoor, Zahra Naeiji, Razyeh Jamali   +4 more
doaj