Results 61 to 70 of about 7,638 (174)

Automated two-step manufacturing of [11C]glyburide radiopharmaceutical for PET imaging in humans

, 2020
International audienceIntroduction: Glyburide is an approved anti-diabetes drug binding to the sulfonylurea receptors-1 (SUR-1) and substrate of solute carrier (SLC) transporters, which can be isotopically radiolabelled with carbon-11 for PET imaging ...
Marie, Solène, Tournier, Nicolas, Kuhnast, Bertrand, Auvity, Sylvain, Caillé, Fabien, Coulon, Christine, Gervais, Philippe   +6 more
core   +1 more source

Risk of Severe Hypoglycemia Associated With Concomitant Use of Sulfonylureas and Amiodarone

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9336-9345, October 2026.
ABSTRACT Aims To evaluate whether initiation of amiodarone while receiving sulfonylurea is associated with an increased risk of severe hypoglycemia compared with the initiation of other antiarrhythmic agents (flecainide, sotalol, or propafenone) while receiving sulfonylurea. Materials and Methods We conducted a population‐based cohort study using South
Sungho Bea, Hyesung Lee, Young Min Cho, You‐Jung Choi, Ju‐Young Shin, Katsiaryna Bykov   +5 more
wiley   +1 more source

Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis. [PDF]

, 2011
BACKGROUND: Patients with diabetes mellitus are more prone to bacterial sepsis, but there are conflicting data on whether outcomes are worse in diabetics after presentation with sepsis.
Direk Limmathurotsakul, van der Poll, T, Schreiber, M. Fernanda, Sharon J. Peacock, Weera Mahavanakul, Koh, GCKW, Chierakul, Wirongrong, Gavin C. K. W. Koh, Chaowagul, W, Koh, Gavin C. K. W., Maude, Rapeephan R., Rapeephan R. Maude, Wipada Chaowagul, Sue J. Lee, Wirongrong Chierakul, Koh, GC, Peacock, Sharon J., Peacock, SJ, Mahavanakul, Weera, Wuthiekanun, V, Nicholas P. J. Day, Gordon Dougan, Wiersinga, W. Joost, Chaowagul, Wipada, Tom van der Poll, Wiersinga, WJ, Nicholas J. White, M. Fernanda Schreiber, White, Nicholas, Lee, Sue J., Mahavanakul, W, White, Nicholas J., Schreiber, MF, Lee, Sue, Day, Nicholas P. J., Day, NP, Day, NPJ, Maude, RR, Limmathurotsakul, Direk, Limmathurotsakul, D, Lee, SJ, Wuthiekanun, Vanaporn, Dougan, Gordon, W. Joost Wiersinga, Vanaporn Wuthiekanun, Chierakul, W, Day, Nicholas, van der Poll, Tom, White, NJ, Dougan, G   +49 more
core   +1 more source

EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE ACTIVITY IN ALLOXAN-INDUCED DIABETIC RAT HEPATOCYTES

, 1994
In the present study we administrated glyburide (glibenclamide) to type 2 (NIDDM) diabetic rats and determined the effect of such treatment on liver superoxide dismutase (SOD) activity.
ALTAN, N, ENGIN, A, HASANOGLU, E, SINDEL, S, TUNCER, C, ONGUN, CO   +5 more
core   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Dipeptidyl Peptidase‐4 Inhibitors Associated Heart Failure Events in Adult Patients With Type‐2 Diabetes Mellitus Treated With Dipeptidyl Peptidase‐4 Inhibitors: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
DPP‐4 Inhibitors associated withheart failure events in patients with type‐2 diabetes. This study found statistically insignificant summary effect for all DPP‐4 inhibitors combined but found asignificant association of saxagliptin with heart failure events (RR = 1.24, 95% CI 1.05–1.47). Results are to be interpreted with caution.
Shishir Nepal, Shiva Prasad Nepal
wiley   +1 more source

Glyburide transport in the human mammary gland and the placenta: implications for developmental toxicology

, 2005
Results. There was no detectable glyburide in any breast milk samples. There was significant transfer of glyburide against the concentration gradient from fetus to mother. Verapamil did not modify glyburide transport. Background.
Kraemer, Jennifer Marie
core   +1 more source

SCING—Spinal Cord Injury Neuroprotection with Glyburide: a pilot, open-label, multicentre, prospective evaluation of oral glyburide in patients with acute traumatic spinal cord injury in the USA

BMJ Open, 2019
Introduction Acute traumatic spinal cord injury (tSCI) is a devastating neurological disorder with no pharmacological neuroprotective strategy proven effective to date. Progressive haemorrhagic necrosis (PHN) represents an increasingly well-characterised
A Mehta, Amy Janelle Minnema, Warren W Boling, Jan Schwab, H Francis Farhadi   +4 more
doaj   +1 more source

One Size Fits None: Developing a Person‐Centered Approach to Weight Management in Older Adults

Journal of the American Geriatrics Society, EarlyView.
Aruna V. Josyula, Jennifer Muniak, Anushka Tandon, Noelle Marie Javier, Michi Yukawa, Colleen Christmas, Timothy W. Farrell   +6 more
wiley   +1 more source

Glyburide does not influence production of IFNγ.

, 2013
Note. IFNγ = gamma interferon. Mice were treated with glyburide or vehicle for seven days prior to intranasal inoculation with ∼6×102 B. pseudomallei. All mice were treated with ceftazidime starting 24 h after inoculation and continued until sacrifice ...
Tassili A. Weehuizen (473323), Kathrin Krause (473325), Ivo Steinmetz (392595), Liesbeth M. Kager (367131), Tom van der Poll (33907), Gavin C. K. W. Koh (185751), Sharon J. Peacock (35782), Katrin Breitbach (473324), Arjan J. Hoogendijk (473326), Antje Bast (473327), Hanna K. de Jong (304424), W. Joost Wiersinga (33895)   +11 more
core   +1 more source