Results 51 to 60 of about 7,638 (174)
A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce +8 more
wiley +1 more source
Glyburide/Glipizide Combination Therapy in Type 2 Diabetes
, 2002 Objective Research has determined differences in the pharmacokinetics and therapeutic actions of glyburide and glipizide. The goal of this study was to evaluate the hypoglycemic effects of glyburide/glipizide combination therapy in the management of ...
Linda A Jaber
core +1 more source
Journal of Lipid Research, 2007 The purpose of this study was to compare the mechanisms of intestinal retinol (ROL) and carotenoid transport. When differentiated Caco-2 cells were incubated with ROL for varying times, cellular ROL plateaued within 2 h, whereas retinyl ester (RE ...
Alexandrine During, Earl H. Harrison
doaj +1 more source
Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats
Saudi Pharmaceutical Journal, 2021 The aim of the present research was to describe the consequences of hyperlipidemia (HL) on the pharmacokinetics of glibenclamide (Gb) in poloxamer 407-induced hyperlipidemic rats.
Yousef A. Bin Jardan +6 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida +7 more
wiley +1 more source
Neonatal outcomes comparing glyburide and insulin.
, 2014 Neonatal outcomes comparing glyburide and insulin.
Muhammad Amin (169590) +2 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Formulation development and optimization: Encapsulated system of atenolol and Glyburide
, 2016 Objective of this study is to develop; tablet- in- a capsule system, to deliver Atenolol 25mg and Glyburide 5mg in the hard gelatin capsule. In order to improve patient compliance and reduce problems associated with complex therapeutic regimen Atenolol ...
Madiha Maboos
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1004-1015, October 2026.A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear +16 more
wiley +1 more source