Results 51 to 60 of about 7,411 (220)
Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1588-1602, June 2026.ABSTRACT Background Multimorbidity, ≥ 2 chronic conditions as per the World Health Organization, can complicate aging in place and lead to earlier transitions to nursing homes. To inform supportive service intervention planning in naturally occurring retirement communities (NORCs), which are areas where large proportions of older adults reside, we ...
Albana Isai +15 more
wiley +1 more source
A Pharmacologic Approach to the Use of Glyburide in Pregnancy [PDF]
Obstetrics & Gynecology, 2013 Despite widespread use of glyburide to treat pregnancy-related hyperglycemia, the dosing regimen is based in large part on pharmacokinetic and pharmacodynamic studies in men and nonpregnant women. Like many medications used by pregnant women, adequate pharmacokinetic and pharmacodynamic data in pregnancy have been sorely lacking.
Steve N, Caritis, Mary F, Hebert
openaire +2 more sources
Association of Combined Lifestyle Behaviors With Healthspan in Older Adults
Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1614-1625, June 2026.In 11,287 older adults from the ASPirin in Reducing Events in the Elderly (ASPREE) cohort, healthy lifestyle behaviors were defined as Mediterranean diet, regular physical activity, moderate alcohol intake, and non‐smoking. Participants with three or more favorable behaviors had a 40% lower hazard of death, dementia, or persistent physical disability ...
Catherine Robb +13 more
wiley +1 more source
Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats
Saudi Pharmaceutical Journal, 2021 The aim of the present research was to describe the consequences of hyperlipidemia (HL) on the pharmacokinetics of glibenclamide (Gb) in poloxamer 407-induced hyperlipidemic rats.
Yousef A. Bin Jardan +6 more
doaj +1 more source
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Heart Rate Variability in Newborns From Diabetic Mothers: Clinical Application and Significance
Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.Risk factors for GDM contribute to a hyperglycemic intrauterine environment, which may in turn impair ANS function in the offspring. Altered ANS activity can be assessed through measures such as HRV. ABSTRACT Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, arising from inadequate insulin secretion and increased ...
Virginia Beretta +7 more
wiley +1 more source
Drug Design, Development and Therapy, 2018 Zachary A King,1 Kevin N Sheth,1 W Taylor Kimberly,2 J Marc Simard3 1Department of Neurology, Division of Neurocritical Care and Emergency Neurology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Neurology, Division of ...
King ZA +3 more
doaj
British Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez +6 more
wiley +1 more source
Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Nokwanda N. Ngcobo, Ntethelelo H. Sibiya
wiley +1 more source
BMJ Open, 2019 Introduction Acute traumatic spinal cord injury (tSCI) is a devastating neurological disorder with no pharmacological neuroprotective strategy proven effective to date. Progressive haemorrhagic necrosis (PHN) represents an increasingly well-characterised
A Mehta +4 more
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