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Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus

iScience
Summary: Type 2 diabetes mellitus (T2DM) represents a common complication during pregnancy that affects fetoplacental development. We demonstrated the existence of impaired trophoblast syncytialization under hyperglycemic conditions.
Jie Ning, Jie Yan, Shuxian Wang, Zifeng Cui, Yiwei Xue, Juan Juan, Huixia Yang   +6 more
doaj   +1 more source

The Impact of Umbilical Blood Flow Regulation on Fetal Development Differs in Diabetic and Non-Diabetic Pregnancy

Kidney & Blood Pressure Research, 2014
Background/Aims: Diabetes is well-known to influence endothelial function. Endothelial function and blood flow regulation might be different in diabetic and non-diabetic pregnancy.
Jian Li, You-Peng Chen, Yun-Peng Dong, Cai-Hong Yu, Yong-Ping Lu, Xiao-Min Xiao, Berthold Hocher   +6 more
doaj   +1 more source

Association of Pregnancy-Associated Plasma Protein A (PAPP-A) and Gestational Diabetes [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2017
Introduction: Gestational diabetes mellitus is the most common medical complication during pregnancy that negatively affects the health of mother and fetus and neonate. Gestational diabetes mellitus occurs in 3-5% of pregnancies.
Somayeh Ramezani, Mahboubeh Ahmadi, Hamid Saqhafi, Mahmood Alipoor   +3 more
doaj   +1 more source

Gestational Diabetes in the Population Served by Brazilian Public Health Care. Prevalence and Risk Factors [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2020
Objective To assess the prevalence of gestational diabetes mellitus and the main associated risk factors in the population served by the Brazilian Unified Health System in the city of Caxias do Sul, state of Rio Grande do Sul.
Pâmela Antoniazzi dos Santos, José Mauro Madi, Emerson Rodrigues da Silva, Daiane de Oliveira Pereira Vergani, Breno Fauth de Araújo, Rosa Maria Rahmi Garcia   +5 more
doaj   +1 more source

Adverse obstetric outcomes in early‐diagnosed gestational diabetes mellitus: The Japan Environment and Children’s Study

Journal of Diabetes Investigation, 2021
Aims/Introduction To examine adverse outcomes in women with early‐diagnosed gestational diabetes mellitus using data from a large birth cohort study in Japan.
Hyo Kyozuka, Shun Yasuda, Tsuyoshi Murata, Toma Fukuda, Akiko Yamaguchi, Aya Kanno, Akiko Sato, Yuka Ogata, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori, The Japan Environment and Children’s Study (JECS) Group   +13 more
doaj   +1 more source

The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing

Frontiers in Cell and Developmental Biology, 2022
Placenta accreta spectrum disorders (PAS) are severe pregnancy complications that occur when extravillous trophoblast cells (EVTs) invade beyond the uterine inner myometrium and are characterized by hypervascularity on prenatal ultrasound and ...
Jingmei Ma, Jingmei Ma, Jingmei Ma, Yawei Liu, Yawei Liu, Yawei Liu, Yawei Liu, Yawei Liu, Zhirong Guo, Zhirong Guo, Run Sun, Run Sun, Run Sun, Run Sun, Xinrui Yang, Xinrui Yang, Weiran Zheng, Weiran Zheng, Yongdan Ma, Yongdan Ma, Yin Rong, Yin Rong, Yin Rong, Yin Rong, Hongmei Wang, Hongmei Wang, Hongmei Wang, Hongmei Wang, Huixia Yang, Huixia Yang, Zhenyu Xiao, Zhenyu Xiao, Zhenyu Xiao, Zhenyu Xiao, Zhenyu Xiao   +34 more
doaj   +1 more source

Fetal sex and the development of gestational diabetes mellitus in gravidae with multiple gestation pregnancies

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction There is an increasing incidence of pregnancies with twin gestations. One outcome more likely to occur with multiple gestations is gestational diabetes mellitus.
Alexa M. Sassin, Haleh Sangi‐Haghpeykar, Kjersti M. Aagaard   +2 more
doaj   +1 more source

Risk Factors for Gestational Diabetes in Women with Polycystic Ovarian Syndrome

Medicine Science, 2016
We aimed to compare the pre-gestational metabolic states of the women who were previously diagnosed with policystic ovarian syndrome and had gestational diabetes mellitus in the subsequent pregnancy and who did not have gestational diabetes mellitus in ...
Senem Arda Duz, Ilgin Turkcuoglu
doaj   +1 more source

Maternal and neonatal outcomes of gestational diabetes: A retrospective cohort study from Southern India

Journal of Family Medicine and Primary Care, 2015
Background: The prevalence of gestational diabetes is on the rise. Understanding the various outcomes of it is necessary to face this challenge. Objectives: To study the frequency of occurrence of various maternal and fetal outcomes among gestational ...
P R Sreelakshmi, Sanjeev Nair, Biju Soman, Rani Alex, K Vijayakumar, V Raman Kutty   +5 more
doaj   +1 more source

Effects of galactooligosaccharides on maternal metabolism and the gut microbiota during pregnancy

Frontiers in Microbiology
BackgroundThe gut microbiota of pregnant women changes dynamically throughout gestation, adapting to the physiological changes of pregnancy. At the same time, dysbacteriosis is involved in the pathophysiological processes of pregnancy-related diseases ...
Jiayang Wan, Jiayang Wan, Lin An, Zhenghong Ren, Huixia Yang, Huixia Yang, Jingmei Ma, Jingmei Ma   +7 more
doaj   +1 more source