Results 61 to 70 of about 53,716 (302)

Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle

Scientific Reports, 2021
Developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, the most severe end of neonatal diabetes mellitus, is caused by mutation in the ATP-sensitive potassium (KATP) channel.
Shoichiro Horita, Tomoyuki Ono, Saul Gonzalez-Resines, Yuko Ono, Megumi Yamachi, Songji Zhao, Carmen Domene, Yuko Maejima, Kenju Shimomura   +8 more
doaj   +1 more source

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source

The Involvement of l-Arginine-Nitric Oxide-cGMP-ATP-Sensitive K⁺ Channel Pathway in Antinociception of BBHC, a Novel Diarylpentanoid Analogue, in Mice Model

Molecules, 2021
The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC ...
Hui Ming Ong, Ahmad Farhan Ahmad Azmi, Sze Wei Leong, Faridah Abas, Enoch Kumar Perimal, Ahmad Akira Omar Farouk, Daud Ahmad Israf, Mohd Roslan Sulaiman   +7 more
doaj   +1 more source

Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]

, 1990
An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Quasthoff, Stefan, Lehmann-Horn, Frank, Strupp, Michael, Grafe, Peter   +3 more
core   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel [PDF]

PeerJ, 2018
Background ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. KATP dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina ...
Alfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga   +6 more
doaj   +2 more sources

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy [PDF]

, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage.
Dale, T, Nan Lin, Brown, Pamela, England, Sarah, Pamela Brown, Jeff Jerman, McCavera, Samantha, Rand, DA, Tickle, D, Kettleborough, Catherine, McCavera, S, Brosens, Jan, Taggart, MJ, Chan, YW, Trezise, Derek J., Catherine Kettleborough, Manu Vatish, Denton, JS, Jerod S Denton, van den Berg, HA, Siobhan Quenby, Atia, Jolene, Cara Rada, England, Sarah K, Rada, C, Rada, Cara, Rand, David A., Shmygol, A, Catalano, R, Vatish, M, Brown, P, van den Berg, Hugo A., Dale, Timothy, David A Rand, Michael J Taggart, Kettleborough, C, McCloskey, C., Lin, Nan, McCloskey, C, Bailey, Elizabeth H., Chan, Yi-Wah, Vatish, Manu, Jerman, J, Andrew M Blanks, Sarah K England, Tickle, David, Berg, Hugo van den, Kanumilli, S, Shmygol, Anatoly, England, Sarah K., Quenby, S, Chan, Y-W, Srinivasan Kanumilli, Steve Thornton, Conor McCloskey, Timothy Dale, Zhang, J, Kanumilli, Srinivasan, David Tickle, Catalano, Roberto D., Atia, J, Yi‐Wah Chan, Jan J Brosens, England, S., Trezise, Derek, Paul Wright, Trezise, DJ, Jie Zhang, Roberto Catalano, Quenby, Siobhan, Bailey, Elizabeth, Derek J Trezise, Brosens, Jan J., McCloskey, Conor, Jerman, Jeff, England, SK, Denton, Jerod S., Zhang, Jie, Brosens, JJ, et al,, Wright, P, Thornton, S, Thornton, Steven, Hugo A van den Berg, Jolene Atia, Taggart, Michael J., Blanks, Andrew M., van den Berg, H. A., Thornton, Steve, Catalano, Roberto, Blanks, AM, Samantha McCavera, Rand, D. A., Blanks, Andrew, Denton, Jerod, Lin, N, Taggart, Michael, Wright, Paul, Bailey, E, Elizabeth Bailey, Anatoly Shmygol   +100 more
core   +1 more source

Chlorination‐Enabled Oxygen Control and Dual‐Sulfur Source Aided Trap Passivation to Unlock 8.24% Efficient Sb2S3 Photovoltaic Devices

Advanced Functional Materials, EarlyView.
This work demonstrates a scalable, low‐temperature synthesis strategy that combines a thioacetamide (TA)‐based dual sulfur source with CdS chlorination, enabling the formation of high‐quality Sb2S3 with a reduced open‐circuit voltage loss, resulting in improved device efficiency.
Vijay C. Karade, Namuna Adhikari, Samietha S. Kumar, Alisha Adhikari, Vamsi Borra, Prabodika N. Kaluarachchi, Tingting Zhu, Tyler Brau, Rohini Kanase, Ebin Bastola, Xavier Mathew, Abasi Abudulimu, Adam B. Phillips, Michael J. Heben, Zhaoning Song, Yanfa Yan, Randy J. Ellingson   +16 more
wiley   +1 more source

Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]

, 1989
The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Lehmann-Horn, Frank, Grafe, Peter, Spuler, A.   +2 more
core   +1 more source

Spectroscopic Investigation of Polysulfide Redox Evolution in Catholyte Solutions for Potassium–Sulfur Batteries

Advanced Functional Materials, EarlyView.
Potassium–sulfur batteries are investigated using UV–vis spectroscopy to track the evolution of potassium polysulfide species at elevated temperature. The study reveals sulfur radical anions as key intermediates and shows how solvent composition and cell design influence polysulfide stability, redox behavior, and cycling performance, providing insights
Chiara Morini, Dawid Kasprzak, Lincoln Crowe, Cecilia Spedalieri, Johannes Baller, Naiyu Qi, Fariza Kalyk, Gustav Graeber   +7 more
wiley   +1 more source