Results 71 to 80 of about 3,142,470 (292)

Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts. [PDF]

, 2010
PURPOSE: Deliberate mild hypothermia (MHT) is applied for cerebroprotection after cardiopulmonary resuscitation and during cardiac surgery. MHT has been shown to alter both contractility and relaxation of blood vessels in the brain.
Cho, Sungsam, Maekawa, Takuji, Tosaka, Reiko, Tosaka, Shinya, Hara, Tetsuya, Sumikawa, Koji   +5 more
core   +1 more source

Ionic Precursors Transformed Into Vinyl Acetate Synthesis Catalyst via Reaction‐Driven Restructuring

Advanced Functional Materials, EarlyView.
This work demonstrates that a simple physical mixture of Pd and Au ionic precursors, KOAc promoter, and SiO2 support can transform into a highly active vinyl acetate synthesis catalyst through reaction‐driven restructuring. The results highlight reaction‐induced restructuring as an innovative and sustainable catalyst design strategy.
Byeong Jun Cha, Welman C. Elias, Hunter P. Jacobs, Kimberly N. Heck, Saghar Rezaie, Sadegh Yazdi, Kiheon Hong, Justin J. Dodson, Laiyuan Chen, Sean G. Mueller, Steven R. Alexander, Michael S. Wong   +11 more
wiley   +1 more source

The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel

Cell Reports, 2019
Summary: Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive potassium channel (KATP).
Dian Ding, Mengmeng Wang, Jing-Xiang Wu, Yunlu Kang, Lei Chen   +4 more
doaj   +1 more source

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks

Advanced Functional Materials, EarlyView.
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran, Kalyan Shobhana, Zlatan Trifunovic, Dan Smith, Michael Stuiber, Chennupati Jagadish, Mirella Dottori, Andrea J. O'Connor, Vini Gautam   +8 more
wiley   +1 more source

ATP-Sensitive Potassium Channel

The aim of this chapter is to delve comprehensively into ATP-sensitive potassium (KATP) channel, which is a ubiquitous class of potassium ion channels located in the biological membrane to sense intracellular nucleotide (ATP/ADP) concentration and mediate potassium efflux in various cell types (and mitochondria), thus functions as a link between ...
Hua-Qian Yang, Shuhan Che, Jianyi Huo, Qianqian Yang   +3 more
openaire   +1 more source

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations [PDF]

, 2010
CFTR, the ABC protein defective in cystic fibrosis, functions as an anion channel. Once phosphorylated by protein kinase A, a CFTR channel is opened and closed by events at its two cytosolic nucleotide binding domains (NBDs).
Gadsby, David C., Gadsby, DC, Csanády, László, Csanady, L, Vergani, Paola, Vergani, P   +5 more
core   +1 more source

Bio‐Inspired Artificial Ionic Mechanoreceptor

Advanced Functional Materials, EarlyView.
A skin‐inspired artificial mechanoreceptor based on ionic interactions is presented for biomimetic tactile sensing. Pressure‐driven ionic redistribution within microfluidic channels generates a self‐powered electrical signal without external bias. The generated waveform exhibits mechanoreceptor‐like temporal features, including overshoot and undershoot,
Mohammad Akbari, Jeppe Don, Lasse A. N. Pedersen, John Noee, Rassoul Tabassian   +4 more
wiley   +1 more source

SENSITIVE EFFECTS OF POTASSIUM AND CALCIUM CHANNEL BLOCKING AND ATP-SENSITIVE POTASSIUM CHANNEL ACTIVATORS ON SEMINAL VESICLE SMOOTH MUSCLE CONTRACTIONS

Journal of Research in Medical Sciences, 2000
<font><font color="#555555"><span style="font-size: 10pt; font-family: Tahoma">Background. Seminal vesicle smooth muscle contraction is mediated through sympathetic and parasympathetic neurons activity. Although seminal vesicle plays an
H SADRAEI
doaj  

A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertension on the Basis of a New Development Concept

Pharmaceuticals, 2010
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 95% of the sodium filtered from the glomeruli before sodium reaches the distal connecting tubules. Excess sodium intake requires the renal kallikrein-kinin
Masataka Majima, Makoto Katori
doaj   +1 more source