ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential [PDF]
Cells, 2022 Globally, migraine is a leading cause of disability with a huge impact on both the work and private life of affected persons. To overcome the societal migraine burden, better treatment options are needed.
Amalie Clement +3 more
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Early Effects of Metabolic Syndrome on ATP-Sensitive Potassium Channels from Rat Pancreatic Beta Cells [PDF]
Metabolites, 2022 Metabolic syndrome (MS) is a cluster of metabolic signs that increases the risk of developing type 2 two diabetes mellitus and cardiovascular diseases. MS leads to pancreatic beta cell exhaustion and decreased insulin secretion through unknown mechanisms
Iskra Cruz-Cruz +5 more
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Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection [PDF]
Frontiers in PhysiologyIntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan +14 more
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The therapeutic agents that target ATP-sensitive potassium channels [PDF]
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
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Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels [PDF]
FunctionThe adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits, are essential for glucose homeostasis.
Athena H Li +3 more
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Modulatory Effect of Medicinal Plants and Their Active Constituents on ATP-Sensitive Potassium Channels (KATP) in Diabetes [PDF]
Pharmaceuticals, 2023 Hyperglycemia, which is a chronic metabolic condition caused by either a defect in insulin secretion or insulin resistance, is a hallmark of diabetes mellitus (DM).
Lina T. Al Kury
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Endothelial biology and ATP-sensitive potassium channels. [PDF]
Channels (Austin), 2018 ATP sensitive potassium (KATP) channels are metabolic sensors with channel activity promoted by decreases in ATP and\or increases in MgADP.
Aziz Q, Li Y, Tinker A.
europepmc +5 more sources
Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels [PDF]
Frontiers in Physiology, 2013 ATP-sensitive potassium (KATP) channels link cell metabolism to membrane excitability and are involved in a wide range of physiological processes including hormone secretion, control of vascular tone, and protection of cardiac and neuronal cells against ...
Gregory M. Martin +3 more
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Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia [PDF]
Respiratory Research, 2018 Background ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion ...
Maurizio Turzo +4 more
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The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia [PDF]
Scientific Reports, 2021 The aim of this study is to establish the expression of ATP-sensitive potassium channels(KATP) in human umbilical arteries with severe pre-eclampsia.
Benlan Yin +7 more
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