Results 21 to 30 of about 2,749,588 (276)

ATP-sensitive K(+)-channels in muscle cells: features and physiological role [PDF]

The Ukrainian Biochemical Journal, 2014
ATP-sensitive K+-channels of plasma membranes belong to the inward rectifier potassium channels type. They are involved in coupling of electrical activity of muscle cell with its metabolic­ state.
O. B. Vadzyuk
doaj   +1 more source

Control of neurovascular coupling by ATP-sensitive potassium channels. [PDF]

J Cereb Blood Flow Metab
Regional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demonstrate the striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (K ATP ) channels in control of NVC in the sensory ...
Bowen RM, York NW, Padawer-Curry J, Bauer AQ, Lee JM, Nichols CG.   +5 more
europepmc   +3 more sources

Identification of an ATP-sensitive potassium channel in mitochondria [PDF]

Nature, 2019
Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood. Here we confirm the existence of a protein complex localized in mitochondria that mediates ATP-dependent potassium currents (
Paggio A., Checchetto V., Campo A., Menabo R., DI MARCO, GIULIA, Di Lisa F., Szabo I., Rizzuto R., De Stefani D.   +8 more
openaire   +2 more sources

ATP-sensitive potassium transport in rat brain mitochondria is highly sensitive to mK(ATP) channels openers: a light scattering study [PDF]

The Ukrainian Biochemical Journal, 2020
The aspects of ATP-sensitive K+ transport regulation by mitochondrial K+,ATP-sensitive (mKATP) channels openers are important for understanding the properties of these channels.
O. V. Akopova, L. I. Kolchinskaya, V. I. Nosar, A. N. Smirnov, L. V. Bratus   +4 more
doaj   +1 more source

Structure of a Pancreatic ATP-Sensitive Potassium Channel [PDF]

Cell, 2017
ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated extensively in a spectrum of metabolic diseases and disorders.
Ningning, Li, Jing-Xiang, Wu, Dian, Ding, Jiaxuan, Cheng, Ning, Gao, Lei, Chen   +5 more
openaire   +2 more sources

The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system [PDF]

British Journal of Pharmacology, 2014
Andrew Tinker, Qadeer Aziz, Alison Thomas   +2 more
exaly   +2 more sources

Postconditioning with D-limonene exerts neuroprotection in rats via enhancing mitochondrial activity

Türk Biyokimya Dergisi, 2023
The key component of neuroprotection after cerebral ischemia–reperfusion (I–R) injury is mitochondrial improvement. By focusing on the function of mitochondrial biogenesis and ATP-sensitive potassium (mK–ATP) channels and inflammatory responses, the ...
Zhang Leguo, Zhao Zeyu, Jia Jianpu, Zhang Liran, Xia Ruixue, Zhu Cuimin   +5 more
doaj   +1 more source

Role of potassium conductance in mechanisms of exrtacellular atp impact on the contractive activity of vascular smooth muscle cells

Бюллетень сибирской медицины, 2017
The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with ...
S. N. Orlov, L. V. Smagliy, S. V. Gusakova, V. S. Rydchenko, Yu. G. Birulina, A. N. Baikov, V. N. Vasiliyev, G. A. Sukhanova, T. S. Fedorova, T. V. Lasukova   +9 more
doaj   +1 more source

Moxifloxacin and gemifloxacin mediates its antispasmodic profile via ATP-sensitive potassium channels: An in-vitro bioassay study

Pakistan Journal of Pharmaceutical Sciences, 2021
Moxifloxacin and gemifloxacin were tested on isolated rabbits’ jejunal preparations as little is known about its effects on gastrointestinal tissues.
Abidullah, Shujaat Ahmad, Niaz Ali, Feras Almarshad, Muhammad Nabi, Shafiq Ur Rahman, Shakir Ullah, Jahangir Khan, Haya Hussain, Syeda Hajira Bukhari   +9 more
doaj   +1 more source

Inhibition of ATP‐sensitive potassium channels by haloperidol [PDF]

British Journal of Pharmacology, 2004
Chronic haloperidol treatment has been associated with an increased incidence of glucose intolerance and type‐II diabetes mellitus. We studied the effects of haloperidol on native ATP‐sensitive potassium (KATP) channels in mouse pancreatic β cells and on cloned Kir6.2/SUR1 channels expressed in HEK293 cells.
Yang, S, Proks, P, Ashcroft, F, Rupnik, M   +3 more
openaire   +3 more sources