ATP-sensitive potassium transport in rat brain mitochondria is highly sensitive to mK(ATP) channels openers: a light scattering study [PDF]
The Ukrainian Biochemical Journal, 2020 The aspects of ATP-sensitive K+ transport regulation by mitochondrial K+,ATP-sensitive (mKATP) channels openers are important for understanding the properties of these channels.
O. V. Akopova +4 more
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Identification of an ATP-sensitive potassium channel in mitochondria [PDF]
Nature, 2019 Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood. Here we confirm the existence of a protein complex localized in mitochondria that mediates ATP-dependent potassium currents (
Paggio A. +8 more
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Structure of a Pancreatic ATP-Sensitive Potassium Channel [PDF]
Cell, 2017 ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated extensively in a spectrum of metabolic diseases and disorders.
Ningning, Li +5 more
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Postconditioning with D-limonene exerts neuroprotection in rats via enhancing mitochondrial activity
Türk Biyokimya Dergisi, 2023 The key component of neuroprotection after cerebral ischemia–reperfusion (I–R) injury is mitochondrial improvement. By focusing on the function of mitochondrial biogenesis and ATP-sensitive potassium (mK–ATP) channels and inflammatory responses, the ...
Zhang Leguo +5 more
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Бюллетень сибирской медицины, 2017 The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with ...
S. N. Orlov +9 more
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Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]
, 2000 The objective was to investigate whether myocardial adenosine triphosphate-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J. +2 more
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Anaesthetic phencyclidine, blocker of the ATP‐sensitive potassium channels [PDF]
FEBS Letters, 1994 The double sucrose gap and patch‐clamp studies revealed that phencyclidine blocked the ATP‐sensitive K+ channel in isolated cardiac cells (half‐maximal inhibition at ≈20 μM; Hill coefficient ≈1). 10μM phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae.
Kokoz, Yuri M. +4 more
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A KATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]
, 2001 Low concentrations of certain K<sub>ATP</sub> channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
Northover, B.J. +5 more
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Intractable hyperkalemia due to nicorandil induced potassium channel syndrome
Annals of Cardiac Anaesthesia, 2015 Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space
Vivek Chowdhry, B B Mohanty
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Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
, 2006 KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
Joshi, Shreena +9 more
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