ATP-sensitive potassium channels and vascular function. [PDF]
Channels (Austin), 2015 ATP-sensitive potassium channels (KATP) are widely distributed in different organs of the body. They are best described in pancreatic β cells and cardiac myocytes but are also present in the periph...
Aziz Q, Li Y, Tinker A.
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Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels [PDF]
Protein & Cell, 2018 ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level.
Jing-Xiang Wu +5 more
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Control of neurovascular coupling by ATP-sensitive potassium channels. [PDF]
J Cereb Blood Flow MetabRegional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demonstrate the striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (K ATP ) channels in control of NVC in the sensory ...
Bowen RM +5 more
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Inhibition of ATP‐sensitive potassium channels by haloperidol [PDF]
British Journal of Pharmacology, 2004 Chronic haloperidol treatment has been associated with an increased incidence of glucose intolerance and type‐II diabetes mellitus. We studied the effects of haloperidol on native ATP‐sensitive potassium (KATP) channels in mouse pancreatic β cells and on cloned Kir6.2/SUR1 channels expressed in HEK293 cells.
Yang, S +3 more
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Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studies [PDF]
Frontiers in EndocrinologyInsulin secretion from pancreatic islet β-cells is governed by both metabolic and electrogenic pathways. The latter involves changes in membrane potential regulated by various potassium channels, including ATP-sensitive K+ (KATP) channels, Ca2+-sensitive
Jing-Jing Xing +2 more
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Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
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Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels
Frontiers in Pharmacology, 2022 Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in
Xiao-Yu Liu +2 more
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The role of potassium channels and calcium in the relaxation mechanism of magnesium sulfate on the isolated rat uterus [PDF]
Archives of Biological Sciences, 2019 MgSO4 is used as a tocolytic agent. It is considered to be a calcium channel antagonist, but a different mechanism of its action might be involved. The aim of this study was to examine the contribution of calcium concentrations and potassium channels in ...
Sokolović Dragana +6 more
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Effects of In Vivo Intracellular ATP Modulation on Neocortical Extracellular Potassium Concentration
Biomedicines, 2022 Neuronal and glial activity are dependent on the efflux of potassium ions into the extracellular space. Efflux of K is partly energy-dependent as the activity of pumps and channels which are involved in K transportation is ATP-dependent.
Azin EbrahimAmini +2 more
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ATP-sensitive K(+)-channels in muscle cells: features and physiological role [PDF]
The Ukrainian Biochemical Journal, 2014 ATP-sensitive K+-channels of plasma membranes belong to the inward rectifier potassium channels type. They are involved in coupling of electrical activity of muscle cell with its metabolic state.
O. B. Vadzyuk
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