Results 11 to 20 of about 2,749,588 (276)
The therapeutic agents that target ATP-sensitive potassium channels [PDF]
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
doaj +4 more sources
Membrane trafficking of ATP-sensitive potassium channels [PDF]
, 2005 ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
core +9 more sources
Role of ATP-sensitive potassium channels in the basilar artery
American Journal of Physiology-Heart and Circulatory Physiology, 1993 This study examined the hypothesis that activation of ATP-sensitive potassium channels produces vasodilation and contributes to dilator responses of the basilar artery to acetylcholine in vivo. Diameter of the basilar artery (baseline diam = 245 +/- 14 microns, means +/- SE) was measured through a cranial window in anesthetized rats. RP52891 (1 microM)
F M, Faraci, D D, Heistad
openaire +3 more sources
Regulation of cholecystokinin secretion by ATP-sensitive potassium channels
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1994 The relationship of potassium channel activity to the secretion of cholecystokinin (CCK) was evaluated in STC-1 cells, an intestinal CCK-secreting cell line. Patch-clamp and 86Rb efflux studies showed that an ATP-sensitive potassium channel was endogenously expressed in STC-1 cells.
A W, Mangel +6 more
openaire +3 more sources
Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
doaj +1 more source
ATP-sensitive potassium channels and vascular function. [PDF]
Channels (Austin), 2015 ATP-sensitive potassium channels (KATP) are widely distributed in different organs of the body. They are best described in pancreatic β cells and cardiac myocytes but are also present in the periph...
Aziz Q, Li Y, Tinker A.
europepmc +4 more sources
Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels
Frontiers in Pharmacology, 2022 Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in
Xiao-Yu Liu +2 more
doaj +1 more source
The role of potassium channels and calcium in the relaxation mechanism of magnesium sulfate on the isolated rat uterus [PDF]
Archives of Biological Sciences, 2019 MgSO4 is used as a tocolytic agent. It is considered to be a calcium channel antagonist, but a different mechanism of its action might be involved. The aim of this study was to examine the contribution of calcium concentrations and potassium channels in ...
Sokolović Dragana +6 more
doaj +1 more source
Effects of In Vivo Intracellular ATP Modulation on Neocortical Extracellular Potassium Concentration
Biomedicines, 2022 Neuronal and glial activity are dependent on the efflux of potassium ions into the extracellular space. Efflux of K is partly energy-dependent as the activity of pumps and channels which are involved in K transportation is ATP-dependent.
Azin EbrahimAmini +2 more
doaj +1 more source
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
, 2006 KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
Joshi, Shreena +2 more
core +5 more sources