Results 21 to 30 of about 19,437 (170)

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Alison Morrissey, Tomoe Y Nakamura, Yoshida, H, Parachuru, L, Nakamura, TY, Coetzee, WA, Lavanya Parachuru, Hidetada Yoshida, Andrew Tinker, Lanning, J, Gwendolyn Lopez, Morrissey, A, Michael Artman, William A Coetzee, Lopez, G, Tong, X, Dhar Chowdhury, P, XiaoYong Tong, Han, S, Jonathan P Giblin, Sandra Han, Giblin, JP, Erika Rosner, Jennifer Lanning, Piyali Dhar Chowdhury, Tinker, A, Rosner, E   +27 more
core   +1 more source

Zoledronic Acid as a Novel Dual Blocker of KIR6.1/2-SUR2 Subunits of ATP-Sensitive K⁺ Channels: Role in the Adverse Drug Reactions

Pharmaceutics, 2021
Zoledronic acid (ZOL) is used as a bone-specific antiresorptive drug with antimyeloma effects. Adverse drug reactions (A.D.R.) are associated with ZOL-therapy, whose mechanics are unknown.
Fatima Maqoud, Rosa Scala, Vincenzo Tragni, Ciro Leonardo Pierri, Maria Grazia Perrone, Antonio Scilimati, Domenico Tricarico   +6 more
doaj   +1 more source

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M, Stephanou, A., Chanalaris, A., Townsend, P. A., Lawrence, K. M., Townsend, P A, Lawrence, KM, Knight, RA, Ferrari, R., Chanalaris, A, Scarabelli, T., Scarabelli, T, Hubank, M., Pasini, E., Townsend, PA, Latchman, D S, Tinker, A., Latchman, D. S., Knight, R A, Pasini, E, Comini, L, Lawrence, K M, Latchman, DS, Tinker, A, Ferrari, R, Comini, L., Knight, R. A., Stephanou, A   +27 more
core   +1 more source

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

Frontiers in Pharmacology, 2019
Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction.
Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova   +8 more
doaj   +1 more source

KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

JCI Insight, 2023
Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer’s disease (AD).
John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, James A. Snipes, Derek Kellar, Emily E. Caesar, Ryan J. Pettit-Mee, Stephen M. Day, Jonathon P. Sens, Noelle I. Nicol, Jasmeen Dhillon, Maria S. Remedi, Drew D. Kiraly, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley   +21 more
doaj   +1 more source

Binding of sulphonylureas to plasma proteins - A KATP channel perspective. [PDF]

PLoS ONE, 2018
Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (KATP) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenuated by
Peter Proks, Holger Kramer, Elizabeth Haythorne, Frances M Ashcroft   +3 more
doaj   +1 more source

The effect of signal pathways on the neural KATP subunits SUR1/Kir6.2 expression induced by Aβ1-42

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To investigate the potential signal transduction mechanism of β⁃amyloid protein1-42 (Aβ1-42) induced up⁃regulation of ATP sensitive potassium channel KATP subunit SUR1/Kir6.2 proteins expression.
LI Yan⁃ju, ZHANG Ge , WANG Xiao⁃jing, XING Xiao⁃min, MA Guo⁃zhao   +4 more
doaj   +1 more source

The therapeutic agents that target ATP-sensitive potassium channels

Acta Pharmaceutica, 2016
ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
doaj   +1 more source

Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen [PDF]

, 2014
The effects of hypoxia on gene expression have been vigorously studied, but possible effects of small changes in oxygen tension have never been addressed.
Sukhodub, Andriy, Mohammed Abdul, Khaja Shameem, Du, Qingyou, Jovanovic, Aleksandar, Khaja Shameem Mohammed Abdul, Sofija Jovanović, Jovanovic, Sofija, Aleksandar Jovanović, Andriy Sukhodub, Qingyou Du   +9 more
core   +1 more source

KATP MD Simulation Trajectories

, 2022
MD simulation trajectories of pancreatic KATP ...
Patton, Bruce L., Zuckerman, Daniel M., Russo, John D., Shyng, Show-Ling, Sung, Min Woo, Mostofian, Barmak, Driggers, Camden M.   +6 more
core   +1 more source