Results 21 to 30 of about 17,716 (217)

Five-year follow-up of incretin-based therapy in a patient with KCNJ11-related permanent neonatal diabetes: Achieving insulin discontinuation and sulfonylurea reduction. [PDF]

J Diabetes Investig
In a woman with KCNJ11‐related permanent neonatal diabetes mellitus, incretin‐based therapy enabled insulin discontinuation and maintained glycemic control for more than 5 years, with HbA1c between 6.1% and 6.5% on the lowest semaglutide dose, dose‐dependent improvement in insulin secretion, and an approximately 60% reduction in glibenclamide dose ...
Ohkuma T, Aotani R, Sakamoto W, Oshiro A, Ago T.   +4 more
europepmc   +2 more sources

Role of KATP channels in sepsis [PDF]

Cardiovascular Research, 2006
Sepsis is an infection-induced inflammatory syndrome responsible for approximately 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure.
James F, Buckley, Mervyn, Singer, Lucie H, Clapp   +2 more
openaire   +2 more sources

Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides

Nature Communications, 2022
KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.
Mengmeng Wang, Jing-Xiang Wu, Dian Ding, Lei Chen   +3 more
doaj   +1 more source

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

iScience, 2022
Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce ...
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya   +18 more
doaj   +1 more source

KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies

Frontiers in Endocrinology, 2023
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh, Assmaa ElSheikh, Show-Ling Shyng   +2 more
doaj   +1 more source

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons [PDF]

, 2016
Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsiveness of
McCrimmon, Rory J.; id_orcid, Ashford, ML, Haythorne, Elizabeth, Hamilton, D. Lee, Haythorne, E, McCrimmon, Rory J., McCrimmon, Rory J, Hamilton, DL, Ashford, Michael L J, Hathorne , Elizabeth, Beall, Craig, Findlay, John A, Hamilton, David Lee, Findlay, John A., Findlay, JA, Ashford, Michael L. J.; id_orcid, Beall, C, McCrimmon, RJ, Ashford, Michael L.J.   +18 more
core   +2 more sources

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

eLife, 2020
Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+
Samuel G Usher, Frances M Ashcroft, Michael C Puljung   +2 more
doaj   +1 more source

Intellectual disability in KATP channel neonatal diabetes [PDF]

Yearbook of Paediatric Endocrinology, 2020
OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized.
Pernille Svalastoga, Åsta Sulen, Jarle R. Fehn, Stein M. Aukland, Henrik Irgens, Eivind Sirnes, Silje K.E. Fevang, Eivind Valen, Irene B. Elgen, Pål R. Njølstad   +9 more
openaire   +2 more sources

KATP MD Simulation Trajectories

, 2022
MD simulation trajectories of pancreatic KATP ...
Patton, Bruce L., Zuckerman, Daniel M., Russo, John D., Shyng, Show-Ling, Sung, Min Woo, Mostofian, Barmak, Driggers, Camden M.   +6 more
core   +1 more source

The effect of signal pathways on the neural KATP subunits SUR1/Kir6.2 expression induced by Aβ1-42

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To investigate the potential signal transduction mechanism of β⁃amyloid protein1-42 (Aβ1-42) induced up⁃regulation of ATP sensitive potassium channel KATP subunit SUR1/Kir6.2 proteins expression.
LI Yan⁃ju, ZHANG Ge , WANG Xiao⁃jing, XING Xiao⁃min, MA Guo⁃zhao   +4 more
doaj   +1 more source