Results 1 to 10 of about 5,030 (211)

Kir6.2 channel activity is regulated by interaction of transmembrane domains 1 and 2 through I167 in the bundle‐crossing gate [PDF]

Physiological Reports
ATP‐sensitive potassium (KATP) channel in pancreatic β‐cells is composed of four pore‐forming inward rectifier potassium (Kir) 6.2 subunits and four regulatory sulfonylurea receptor (SUR) 1 subunits and regulate insulin secretion.
Ryoko Kawashima, Charlotte Meller, Manabu Suzuki, Shigeki Kato, Shoichiro Horita, Shizu Hidema, Shingen Misaka, Mitsuaki Hosoya, Hayato Go, Kazuto Kobayashi, Heidi deWet, Yuko Maejima, Kenju Shimomura   +12 more
doaj   +5 more sources

Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus [PDF]

Molecules
Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease.
Mohamed E. Elangeeb, Imadeldin Elfaki, Ali M. S. Eleragi, Elsadig Mohamed Ahmed, Rashid Mir, Salem M. Alzahrani, Ruqaiah I. Bedaiwi, Zeyad M. Alharbi, Mohammad Muzaffar Mir, Mohammad Rehan Ajmal, Faris Jamal Tayeb, Jameel Barnawi   +11 more
doaj   +3 more sources

Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation

Redox Biology, 2021
Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal therapeutic target for multiple diseases.
Nanshan Song, Yinquan Fang, Sifan Sun
exaly   +3 more sources

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection [PDF]

Frontiers in Physiology
IntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan, Samir Makwana, Shen Chen, Lauren R. McGuinness, Moustafa Sweihi, Jacob A. Whitmore, Mahmoud E. Elghayesh, Mahmoud E. Elghayesh, Christopher A. Martin, Noorann Sheikh, Manish Patel, Phoebe Malin, Mark W. Sims, Caroline Dart, Richard D. Rainbow   +14 more
doaj   +2 more sources

Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell KATP channels [PDF]

Frontiers in Physiology
ATP-sensitive potassium (KATP) channels link beta-cell metabolism to electrical activity. By modulating the beta-cell membrane potential, they finely regulate glucose-stimulated insulin secretion.
Natascia Vedovato, Natascia Vedovato, Frances M. Ashcroft, Brian Catchpole, Lucy J. Davison, Lucy J. Davison   +5 more
doaj   +2 more sources

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface [PDF]

Nature Communications
ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells.
Camden M. Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng   +4 more
doaj   +2 more sources

Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels [PDF]

Channels
Vascular smooth muscle ATP-sensitive potassium (KATP) channels play critical roles in modulating vascular tone and thus represent important drug targets for diverse cardiovascular pathologies.
Kangjun Li, Vaishali Satpute Janve, Jerod Denton   +2 more
doaj   +2 more sources

Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels [PDF]

Function
The adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits, are essential for glucose homeostasis.
Athena H Li, Wen-Sheng Tsai, Wen-Hao Tsai, Shi-Bing Yang   +3 more
doaj   +2 more sources

Loss of Beta-Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes. [PDF]

MedComm (2020)
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Patel S, Yan Z, Remedi MS.
europepmc   +2 more sources

Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice

eLife, 2022
ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secretion
Yajamana Ramu, Jayden Yamakaze, Yufeng Zhou, Toshinori Hoshi, Zhe Lu   +4 more
doaj   +1 more source