Results 31 to 40 of about 5,030 (211)
Assembly of KATP channels from SUR1 and KIR6.2 [PDF]
Kidney International, 2001 cretion, and other cellular functions. Unexpectedly, islets Adenosine 5 -triphosphate-sensitive potassium (KATP) from Sur1KO mice are refractory to GLP-1 and GIP, channels are unique combinations of potassium inward gastrointestinal peptides known to potentiate glucoserectifiers (KIR6.x) and sulfonylurea receptors (SURs), induced insulin secretion by ...
Bryan, Joseph +3 more
openaire +1 more source
eLife, 2017 KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas.
Gregory M Martin +7 more
doaj +1 more source
JCI Insight, 2023 Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer’s disease (AD).
John Grizzanti +21 more
doaj +1 more source
The unusual stoichiometry of ADP activation of the KATP channel
Frontiers in Physiology, 2014 KATP channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR.
Eric eHosy, Michel eVivaudou
doaj +1 more source
Pharmaceutics, 2021 Zoledronic acid (ZOL) is used as a bone-specific antiresorptive drug with antimyeloma effects. Adverse drug reactions (A.D.R.) are associated with ZOL-therapy, whose mechanics are unknown.
Fatima Maqoud +6 more
doaj +1 more source
Ankyrin-B Regulates Kir6.2 Membrane Expression and Function in Heart [PDF]
Journal of Biological Chemistry, 2010 Ankyrin polypeptides are critical for normal membrane protein expression in diverse cell types, including neurons, myocytes, epithelia, and erythrocytes. Ankyrin dysfunction results in defects in membrane expression of ankyrin-binding partners (including ion channels, transporters, and cell adhesion molecules), resulting in aberrant cellular function ...
Jingdong, Li +4 more
openaire +2 more sources
KATP channel dependent heart multiome atlas
Scientific Reports, 2022 Plasmalemmal ATP sensitive potassium (KATP) channels are recognized metabolic sensors, yet their cellular reach is less well understood. Here, transgenic Kir6.2 null hearts devoid of the KATP channel pore underwent multiomics surveillance and systems ...
D. Kent Arrell +8 more
doaj +1 more source
Cloning and Functional Expression of the Rat Brain KIR6.2 Channel.
The Japanese Journal of Physiology, 1996 We obtained cDNA encoding KIR6.2 channel from the rat brain cDNA library. The reconstituted K+ channel with KIR6.2 and SUR1 genes retained properties similar to those reported in the native ATP-sensitive K+ channel including run-down and recovery of channel activity. When KIR6.2 was co-expressed with CFTR or MDR1, no K+ channel activity was recorded.
TAKANO, Makoto +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2023 Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in cancer is poorly described. Pituitary macroadenoma has been observed in Cantu’ syndrome (C.S.), which is associated with the gain-of-function mutations of the ABCC9 ...
Fatima Maqoud +8 more
doaj +1 more source
Video3_Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels.MP4
, 2021 ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell ...
Sarala Pellikan (11254941) +2 more
core +1 more source