Results 51 to 60 of about 5,030 (211)
Journal of Diabetes Investigation, Volume 17, Issue 6, Page 1075-1078, June 2026.In a woman with KCNJ11‐related permanent neonatal diabetes mellitus, incretin‐based therapy enabled insulin discontinuation and maintained glycemic control for more than 5 years, with HbA1c between 6.1% and 6.5% on the lowest semaglutide dose, dose‐dependent improvement in insulin secretion, and an approximately 60% reduction in glibenclamide dose ...
Toshiaki Ohkuma +4 more
wiley +1 more source
Flexibility of the Kir6.2 inward rectifier K + channel pore [PDF]
Proceedings of the National Academy of Sciences, 2001 Interactions of sulfhydryl reagents with introduced cysteines in the pore-forming (Kir6.2) subunits of the K ATP channel were examined. 2-Aminoethyl methanethiosulfonate (MTSEA + ) failed to modify Cd 2+ -insensitive control-Kir6.2 channels, but rapidly and ...
G, Loussouarn +4 more
openaire +2 more sources
, 2004 9 páginas, 7 figuras, 2 tablas -- PAGS nros. 585-593The role of the K-ATP channel pore-forming subunit Kir6.2 on protection from cerebral hypoxic–ischemic injury was assessed in transgenic mice overexpressing normal Kir6.2 or a dominant negative form ...
Mobbs, Charles +9 more
core +1 more source
Video1_Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels.MP4
, 2021 ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell ...
Sarala Pellikan (11254941) +2 more
core +1 more source
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Accounting for Near-Normal Glucose Sensitivity in Kir6.2[AAA] Transgenic Mice [PDF]
Biophysical Journal, 2009 K(ir)6.2[AAA] transgenic mouse islets exhibit mosaicism such that approximately 70% of the beta-cells have nonfunctional ATP-sensitive potassium (K(ATP)) channels, whereas the remainder have normal K(ATP) function. Despite this drastic reduction, the glucose dose-response curve is only shifted by approximately 2 mM.
Tsaneva-Atanasova, KT, Sherman, Arthur
openaire +4 more sources
Molecular structure of human KATP in complex with ATP and ADP
eLife, 2017 In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ABC transporter SUR1 and the inward-rectifier K ...
Kenneth Pak Kin Lee +2 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.In the non‐diabetic beta‐cell (top left) activation of glucokinase (bottom left) leads to inhibition of mitochondrial metabolism and thereby impairs insulin secretion. The effect is similar to that of chronic hyperglycaemia as seen in the diabetic beta‐cell (top right).
Matthew Lloyd +9 more
wiley +1 more source
Membrane trafficking of ATP-sensitive potassium channels [PDF]
, 2005 ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
core
A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel
, 2018 The adenosine triphosphate (ATP)-sensitive (KATP) channels in pancreatic β cells couple the blood glucose level to insulin secretion. KATP channels in pancreatic β cells comprise the pore-forming Kir6.2 and the modulatory sulfonylurea receptor 1 (SUR1 ...
Yajamana Ramu, Yanping Xu, Zhe Lu
core +1 more source