Results 71 to 80 of about 5,030 (211)

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2

, 2011
Functional integrity of pancreatic adenosine triphosphate (ATP)-sensitive potassium (KATP) channels depends on the interactions between the pore-forming potassium channel subunit Kir6.2 and the regulatory subunit sulfonylurea receptor 1 (SUR1).
Paul Tewson, Cathrin E. Bruederle, Show-Ling Shyng, William R. Skach, Emily B. Pratt   +4 more
core   +1 more source

Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study

Journal of Arrhythmia, Volume 41, Issue 6, December 2025.
Mendelian randomization analyses suggest that genetic proxies for antidiabetic drug targets—KCNJ11/ABCC8, SLC5A2, and RXRB—reduce the risk of paroxysmal tachycardia (PT), right bundle branch block (RBBB), and atrial fibrillation (AF), respectively.
Zheng‐Qi Song, Zhi‐Bo Zhou, Bo‐Xiang Wang, Sheng‐Ke Wu, Yi‐Han Sun, Yi‐He Chen, Su‐Yin Feng, Run‐Feng Sun   +7 more
wiley   +1 more source

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.

, 2004
ATP-sensitive potassium (K(ATP)) channels comprise Kir6.2 and SUR subunits. The site at which ATP binds to mediate K(ATP) channel inhibition lies on Kir6.2, but the potency of block is enhanced by coexpression with SUR1.
Michael Dabrowski, Ashcroft, FM, Andrei Tarasov, Tarasov, A, Frances M. Ashcroft, Dabrowski, M, Ashcroft, Frances   +6 more
core   +1 more source

Pushing Biomolecule Detection Limit With Graphene Field‐effect Transistor Biosensors

Advanced Electronic Materials, Volume 11, Issue 19, November 18, 2025.
Graphene knows your health! This work presents a comprehensive overview of recent advances in graphene field‐effect transistor (GFET) biosensors for ultrasensitive biomolecule detection. How device engineering, high‐mobility graphene synthesis, and tailored surface chemistry push detection limits is highlighted, while discussing emerging strategies ...
Co Dang Pham, Quang Thang Trinh, Jun Zhang, Nam‐Trung Nguyen, Tuan‐Khoa Nguyen   +4 more
wiley   +1 more source

Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice

, 2001
ATP-sensitive potassium (K ATP) channels were discovered in ventricular cells, but their roles in the heart remain mysterious. K ATP channels have also been found in numerous other tissues, including vascular smooth muscle.
Tamagawa, M, Nakaya, H, Suzuki, M, Seino, S, Sakamoto, N, Miki, T, Li, RA, Uemura, H, OhmotoSekine, Y, Ogura, T, Marbán, E   +10 more
core   +1 more source

β2-Adrenergic ion-channel coupled receptors as conformational motion detectors.

PLoS ONE, 2011
Ion Channel-Coupled Receptors (ICCRs) are artificial proteins comprised of a G protein-coupled receptor and a fused ion channel, engineered to couple channel gating to ligand binding.
Lydia N Caro, Christophe J Moreau, Jean Revilloud, Michel Vivaudou   +3 more
doaj   +1 more source

Clinical and Molecular Heterogeneity Underlying Monogenic Causes of Pediatric Diabetes Associated to Brain Developmental Disorders

Clinical Genetics, Volume 108, Issue 5, Page 495-510, November 2025.
A growing number of genetic variants linking non‐autoimmune diabetes to NDDs across different ages offer key insights about a common background of these phenotypes. These findings call for multidisciplinary approaches to care that integrate metabolic and neurological management in affected children.
Gabriele Di Pasquale, Camilla Valsecchi, Giulia Marie Smylie, Vincenzo Salpietro, Gian Vincenzo Zuccotti, Maurizio Delvecchio, Chiara Mameli   +6 more
wiley   +1 more source

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

, 2006
ATP-sensitive potassium (K(ATP)) channels, composed of pore-forming Kir6.2 and regulatory sulphonylurea receptor (SUR) subunits, play an essential role in insulin secretion from pancreatic beta cells.
Proks, P, Perez de Nanclares, G, Castano, L, Girard, CA, Absalom, N, Ashcroft, Frances, Shimomura, K   +6 more
core   +1 more source

Tamoxifen Inhibits Cardiac ATP-Sensitive and Acetylcholine-Activated K+ Currents in Part by Interfering With Phosphatidylinositol 4,5-Bisphosphate–Channel Interaction

Journal of Pharmacological Sciences, 2010
Tamoxifen inhibits transmembrane currents of the Kir2.x inward rectifier potassium channels by interfering with the interaction of the channels with membrane phosphatidylinositol 4,5-bisphosphate (PIP2).
Daniela Ponce-Balbuena, Eloy G. Moreno-Galindo, Angélica López-Izquierdo, Tania Ferrer, José A. Sánchez-Chapula   +4 more
doaj   +1 more source