Results 81 to 90 of about 5,030 (211)
The Journal of Physiology, Volume 603, Issue 22, Page 7207-7233, November 15, 2025.Abstract figure legend Schematic of REST/NRSF‐dependent postsynaptic downscaling of excitatory strength in response to glycolysis inhibition Glycolysis inhibition enhances REST/NRSF expression and increases REST/NRSF transcriptional repressor activity by promoting its translocation into the nucleus.
Daniele Ferrante +10 more
wiley +1 more source
Engineered pH-Dependence at the Kir6.2 Helix Bundle Crossing [PDF]
Biophysical Journal, 2011 The hallmark functional property of KATP (ATP-sensitive potassium) channels is inhibition by intracellular ATP, which binds to a well-defined binding site on Kir6.x subunits and stabilizes the closed conformation of a gate in the channel pore. Numerous inwardly-rectifying potassium (Kir) channels possess an aromatic residue in the ‘helix bundle ...
Khurana, Anu +4 more
openaire +1 more source
Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
eLife, 2020 We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density.
Hua-Qian Yang +7 more
doaj +1 more source
Loss of β‐cell identity in human islets treated with glibenclamide
Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5782-5792, October 2025.Abstract Aims Loss of β‐cell identity can contribute to the reduction of functional β‐cell mass in type 2 diabetes. Sulfonylureas show shorter durability of antihyperglycaemic action and higher rates of secondary failure compared to other antihyperglycaemic agents, suggesting that they could accelerate the decline of β‐cell functional mass in type 2 ...
Claudia Fernández +9 more
wiley +1 more source
Molecular Mechanisms of Chloroquine Inhibition of Heterologously Expressed Kir6.2/SUR2A Channels [PDF]
Molecular Pharmacology, 2012 Chloroquine and related compounds can inhibit inwardly rectifying potassium channels by multiple potential mechanisms, including pore block and allosteric effects on channel gating. Motivated by reports that chloroquine inhibition of cardiac ATP-sensitive inward rectifier K(+) current (I(KATP)) is antifibrillatory in rabbit ventricle, we investigated ...
Daniela, Ponce-Balbuena +6 more
openaire +2 more sources
The KATP channel Kir6.2 is new target for Alzheimer’s disease therapy
, 2016 Here we report a novel target, ATP-sensitive K+ (KATP) channels, of memantine implicated in memory improvement. We confirmed that memantine improves memory impairment in Alzheimer’s model APP23 mice.
Sakagami, Hiroyuki +20 more
core +1 more source
The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
, 2007 Mutations in Kir6.2, the pore-forming subunit of the K ATP channel, that reduce the ability of ATP to block the channel cause neonatal diabetes. The stimulatory effect of MgATP mediated by the regulatory sulphonylurea receptor (SUR) subunit of the ...
Tammaro, P +3 more
core +1 more source
Brain and Behavior, Volume 15, Issue 9, September 2025.This study identified six potential druggable genes (CALCRL, KCNJ11, NEK3, THSD1, MMP12, and HSD17B12) associated with ischemic stroke risk using a systematic druggable genome‐wide Mendelian randomization analysis. ABSTRACT Background Ischemic stroke (IS) treatment remains a significant challenge.
Peng Zhang +3 more
wiley +1 more source
Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy
MedComm, Volume 6, Issue 9, September 2025.The pancreatic islets, composed of α, β, δ, ε, and PP cells, play a central role in maintaining glucose homeostasis. This review examines the mechanisms of islet hormone secretion and their functional crosstalk networks, alongside the pathophysiology of diabetes driven by hormonal dysregulation.
Jinfang Ma +8 more
wiley +1 more source
Optimized Expression and Purification of Recombinant Kir6.2 delta C26 Channel Protein
, 2010 腺核苷三磷酸感受性鉀離子通道 (KATP channels) 由兩種蛋白組成一異八分子聚合體：其中第六型內向性整流型鉀離子通道蛋白 (Kir6.x) 形成鉀離子篩選孔洞；而磺脲受體蛋白 (SUR) 則與調控有關。此通道廣泛分佈於不同組織：包括胰臟β細胞、心肌與骨骼肌細胞，並受細胞內之腺核苷三磷酸 (ATP)、二磷酸脂酰肌醇 (PIP2) 及MgATP濃度所調控。第六型內向性整流型鉀離子通道蛋白 (Kir6.2) 構造上主要有兩個過膜區域；生理功能主要是負責運送鉀離子及穩定靜止膜電位 ...
Huang, Chun-Man, 黃春滿
core