Results 91 to 100 of about 5,030 (211)

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats. [PDF]

, 2008
We investigated on the mechanism responsible for the reduced ATP-sensitive K(+)(K(ATP)) channel activity recorded from skeletal muscle of K(+)-depleted rats. Patch-clamp and gene expression measurements of K(ATP) channel subunits were performed.
Tricarico, Domenico, Mele, Antonietta, Mele, A, Liss, Birgit, Tricarico, D, George J.R. , Alfred L., Ashcroft, Frances, Lundquist, AL, Conte Camerino, D, Ashcroft, FM, George, AL, Desai, Reshma R., Lundquist, Andrew L., Conte Camerino, Diana, Desai, RR, Liss, B, Ashcroft, Frances M.   +16 more
core   +1 more source

Modeling Genetic Risk of β‐Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant

Journal of Pineal Research, Volume 77, Issue 5, September 2025.
ABSTRACT Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B (MTNR1B) is robustly associated with increased risk of T2D.
Tania Singh, Sebastian Kalamajski, João. P. M. C. M. Cunha, Siarhei Hladkou, Fiona Roberts, Sevda Gheibi, Anahita Soltanian, Kaveh Yektay Farahmand, Ola Ekström, Anant Mamidi, Paul. W. Franks, Anders Rosengren, Henrik Semb, Hindrik Mulder, Malin Fex   +14 more
wiley   +1 more source

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. [PDF]

, 2005
ATP-sensitive potassium (K(ATP)) channels conduct potassium ions across cell membranes and thereby couple cellular energy metabolism to membrane electrical activity.
Zadek, B, Sansom, MS, Campbell, JD, Ford, RC, Zadek, Brittany, Collins, Richard F., Sansom, Mark S P, De Wet, H, Ashcroft, Frances, Shimomura, K, Mikhailov, Michael V., Shimomura, Kenju, Ashcroft, FM, Ford, Robert C., Mikhailov, MV, Collins, RF, Campbell, Jeff D., De Wet, Heidi, Ashcroft, Frances M.   +18 more
core   +1 more source

Sulphonylureas as Adjunct Therapeutic Agents in the Treatment of Autoimmune Conditions: A Narrative Review

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
NLRP3 Inflammasome activation drives inflammatory responses through the production and activation of pro‐inflammatory cytokines. Repurposing sulphonylureas and their derivatives to target NLRP3 may act as adjunct therapeutics for autoimmune conditions. ABSTRACT A rapid and cost‐effective arm of the drug discovery and development process is finding new ...
Jasen Elford, Robert J. O'Reilly, Anna‐Marie Babey, Rukshan Ahamed Mohamed Rafeek, Natkunam Ketheesan   +4 more
wiley   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
core  

Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels.

, 2013
ATP-sensitive K(+) (K(ATP)) channels, comprised of pore-forming Kir6.x and regulatory SURx subunits, play important roles in many cellular functions; because of their sensitivity to inhibition by intracellular ATP, K(ATP) channels provide a link between ...
Grottesi, A, Tammaro, P, Chadburn, AJ, Tammaro, Paolo, Moran, O   +4 more
core   +1 more source

A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.

PLoS ONE, 2013
In the absence of intracellular nucleotides, ATP-sensitive potassium (KATP) channels exhibit spontaneous activity via a phosphatidylinositol-4,5-bisphosphate (PIP2)-dependent gating process.
Jeremy D Bushman, Qing Zhou, Show-Ling Shyng   +2 more
doaj   +1 more source

Expression and purification of the Kir6.2 channels

, 2007
內向性整流型鉀離子通道Kir6.2 (Inwardly rectifying potassium channels; Kir6.2)屬於Kir離子通道中的第六族，廣泛分布於身體不同的組織，特別在腦部、骨骼肌和胰臟β細胞中最多，並且調控許多重要生理功能如維持細胞靜止膜電位、胰島素分泌以及骨骼肌的收縮等。近十年的研究已知SUR (sulphonylurea receptor)分子與調控Kir6.2的開啟有關，根據電生理的研究分析而知 ATP、MgADP、PIP2 (phosphatidyl-inositol-
Hsu, Pi-Jung, 許碧絨
core  

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.

, 2003
The pancreatic beta-cell type of ATP-sensitive potassium (KATP) channel (Kir6.2/SUR1) is inhibited by intracellular ATP and ADP, which bind to the Kir6.2 subunit, and is activated by Mg-nucleotide interaction with the regulatory sulphonylurea receptor ...
Michael Dabrowski, Ashcroft, FM, Trapp, S, Stefan Trapp, Frances M. Ashcroft, Dabrowski, M, Ashcroft, Frances   +6 more
core   +1 more source

Engineering of an artificial light-modulated potassium channel.

PLoS ONE, 2012
Ion Channel-Coupled Receptors (ICCRs) are artificial receptor-channel fusion proteins designed to couple ligand binding to channel gating. We previously validated the ICCR concept with various G protein-coupled receptors (GPCRs) fused with the inward ...
Lydia N Caro, Christophe J Moreau, Argel Estrada-Mondragón, Oliver P Ernst, Michel Vivaudou   +4 more
doaj   +1 more source