Results 1 to 10 of about 2,660,556 (154)
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review
International Journal of Molecular Sciences, 2021 Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor ...
Ruchira M Jha +2 more
exaly +2 more sources
An endogenous ligand for the central sulfonylurea receptor [PDF]
FEBS Letters, 1988 An endogenous ligand for the rat central sulfonylurea receptor has been evidenced in the rat central nervous system. The characteristics of this ligand (extractibility, non‐dialysability, chromatographic behaviour on different media, sensitivity to proteases) indicate that it is a neutral to slightly basic peptide.
Annick Cauvin, D Bataille
exaly +3 more sources
Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease
Diabetes, 2017 Despite widespread clinical use in the treatment of type 2 diabetes, the impact of sulfonylurea therapy on cardiovascular outcomes remains uncertain.
Connor A Emdin +2 more
exaly +2 more sources
Sulfonylurea Receptor 1 Expression in Human Cerebral Infarcts [PDF]
Journal of Neuropathology & Experimental Neurology, 2013 In animal models of stroke, sulfonylurea receptor 1 (Sur1), a member of the adenosine triphosphate binding cassette transporter gene family, is transcriptionally upregulated in neural and vascular cells in which it plays a leading role in edema formation and necrotic cell death. To date, expression of Sur1 in the brains of humans with cerebral infarcts
Mehta, Rupal I. +5 more
openaire +3 more sources
The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C‐terminal 42 amino acids [PDF]
FEBS Journal, 2010 Unusually among ATP‐binding cassette proteins, the sulfonylurea receptor (SUR) acts as a channel regulator. ATP‐sensitive potassium channels are octameric complexes composed of four pore‐forming Kir6.2 subunits and four regulatory SUR subunits. Two different genes encode SUR1 (ABCC8) and SUR2 (ABCC9), with the latter being differentially spliced to ...
Heidi De Wet, Frances M Ashcroft
exaly +7 more sources
FEBS Letters, 2011 Activating mutations in different domains of the ABCC8 gene‐coded sulfonylurea receptor 1 (SUR1) cause neonatal diabetes. Here we show that a diabetogenic mutation in an unexplored helix preceding the ABC core of SUR1 dramatically increases open ...
Andrey P Babenko
exaly +2 more sources
Determination of the molecular mass of the native β-cell sulfonylurea receptor [PDF]
FEBS Letters, 1994 In the present study we have determined the molecular mass of the β‐cell sulfonylurea receptor in its native form by two different experimental approaches; gel filtration chromatography and radiation inactivation analysis. We first confirmed that the denatured photolabelled MIN6 β‐cell receptor had a molecular size of 141 ± 2 kDa (mean ± S.E., n = 8 ...
Michel Potier +2 more
exaly +4 more sources
Biochimica Et Biophysica Acta - Molecular Cell Research, 1992 Stephen J H Ashcroft, Frances M Ashcroft
exaly +3 more sources
International Journal of Molecular Sciences, 2022 New quinazoline-sulfonylurea hybrids were prepared and examined for their in vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as a reference drug.
M. El-Zahabi +7 more
semanticscholar +1 more source
European Journal of Case Reports in Internal Medicine, 2021 Sulfonylurea monotherapy is the standard treatment for patients with the most common form of permanent neonatal diabetes, KCNJ11 neonatal diabetes, but it is not always sufficient.
Morten Hindsø +6 more
doaj +1 more source