Results 21 to 30 of about 1,253,570 (258)

The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis

Frontiers in Endocrinology, 2022
AimsThis study aimed to assess the impact of different antidiabetic agents on individuals with diabetes and COVID-19.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to October 31, 2021 and included seven ...
Yidan Chen, Xingfei Lv, Sang Lin, Mohammad Arshad, Mengjun Dai   +4 more
doaj   +1 more source

Characterization of the rat mesangial cell type 2 sulfonylurea receptor [PDF]

, 1999
Background. Sulfonylurea receptors are classified as either high- affinity type 1 (SUR1) or low-affinity type 2 receptors (SUR2), and the gene expression of SURs has recently been demonstrated in kidney. However, functional data regarding a renal SUR are
Garvin, Jeffrey L, Rodríguez-Barbero, Alicia, Riser, Bruce L, Cortes, Pedro, Szamosfalvi, Balázs, Asano, Kenichiro, Yee, Jerry   +6 more
core   +2 more sources

From ions to insulin

eLife, 2017
Electron cryo-microscopy has revealed the three-dimensional structure of a potassium channel that has a central role in regulating the release of insulin from the pancreas.
Voula Kanelis
doaj   +1 more source

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

eLife, 2017
KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas.
Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng   +7 more
doaj   +1 more source

Transmembrane Topology of the Sulfonylurea Receptor SUR1 [PDF]

Journal of Biological Chemistry, 2001
Sulfonylurea receptors (SURx) are multi-spanning transmembrane proteins of the ATP-binding cassette (ABC) family, which associate with Kir6.x to form ATP-sensitive potassium channels. Two models, with 13-17 transmembrane segments, have been proposed for SURx topologies.
L R, Conti, C M, Radeke, S L, Shyng, C A, Vandenberg   +3 more
openaire   +2 more sources

Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones [PDF]

Diabetes & Metabolism Journal, 2011
BackgroundSulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ ...
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park   +5 more
doaj   +1 more source

A case with relapsed transient neonatal diabetes mellitus treated with sulfonylurea, ending chronic insulin requirement

Endocrinology, Diabetes & Metabolism Case Reports, 2018
We report a case of a woman with diabetes mellitus caused by a genetic defect in ABCC8-coding sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium (KATP) channel protein. She was diagnosed with diabetes at 7 days after birth.
Akihiko Ando, Shoichiro Nagasaka, Shun Ishibashi   +2 more
doaj   +1 more source

Anthelminthic activity of glibenclamide on secondary cystic echinococcosis in mice. [PDF]

PLoS Neglected Tropical Diseases, 2017
Cystic echinococcosis (CE) is a worldwide parasitic zoonosis caused by the larval stage of Echinococcus granulosus. Current chemotherapy against this disease is based on the administration of benzimidazoles (BZMs).
Julia A Loos, María Sandra Churio, Andrea C Cumino   +2 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in Egyptian patients with type 2 diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2011
Objective: This study investigated the possibility that genetic factors, such as polymorphism of K inward rectifier subunit (Kir6.2), E23K, and Arg 972 polymorphism of insulin receptor substrate-1 (IRS-1), may predispose patients to sulfonylurea failure.
Alaa E. El-sisi, Sahar K. Hegazy, Shereen S. Metwally, Alaa M. Wafa, Naglaa A. Dawood   +4 more
doaj   +1 more source