Results 21 to 30 of about 2,674,072 (303)

Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in Egyptian patients with type 2 diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2011
Objective: This study investigated the possibility that genetic factors, such as polymorphism of K inward rectifier subunit (Kir6.2), E23K, and Arg 972 polymorphism of insulin receptor substrate-1 (IRS-1), may predispose patients to sulfonylurea failure.
Alaa E. El-sisi, Sahar K. Hegazy, Shereen S. Metwally, Alaa M. Wafa, Naglaa A. Dawood   +4 more
doaj   +3 more sources

Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations* [PDF]

J Biol Chem, 2016
ATP-sensitive potassium (KATP) channels play a key role in mediating glucose-stimulated insulin secretion by coupling metabolic signals to β-cell membrane potential.
Gregory M. Martin, Emily A. Rex, Prasanna K. Devaraneni, J. Denton, Kara E Boodhansingh, D. Deleon, C. Stanley, S. Shyng   +7 more
semanticscholar   +2 more sources

Sulfonylurea Receptor Pharmacology Alters the Performance of Two Central Pattern Generating Circuits in Cancer borealis [PDF]

Function
Neuronal activity and energy supply must maintain a fine balance for neuronal fitness. Various channels of communication between the two could impact network output in different ways.
Sonal Kedia, Naziru M Awal, Jackie Seddon, Eve Marder   +3 more
doaj   +2 more sources

Effective Treatment With Oral Sulfonylureas in Patients With Diabetes Due to Sulfonylurea Receptor 1 (SUR1) Mutations [PDF]

Diabetes Care, 2008
OBJECTIVE—Neonatal diabetes can result from mutations in the Kir6.2 or sulfonylurea receptor 1 (SUR1) subunits of the ATP-sensitive K+ channel. Transfer from insulin to oral sulfonylureas in patients with neonatal diabetes due to Kir6.2 mutations is well described, but less is known about changing therapy in patients with SUR1 mutations.
Rafiq, Meena, Flanagan, Sarah E., Patch, Ann Marie, Shields, Beverley M., Ellard, Sian, Hattersley, Andrew T., Batra, Chandar, Bruining, Jan, Carson, Dennis, Codner, Ethel, Cummings, Elizabeth, Curran, Jacqueline, Davis, Elizabeth, Deiss, Dorothee, Herr, Mathias, Hussain, Khalid, Legault, Laurent, Malecki, Maciek, Paskova, Magdalena, Pearson, Ewan, Rodda, Christine, Rothenbuhler, Anya, Sanchez, Juan, Shield, Julian, Stanca, Ràcealà Motoc, Van Der Meulen, John   +25 more
openaire   +6 more sources

Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit

Molecules, 2015
Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by 1H-NMR, 13C-NMR, MS spectrum and elemental analysis.
Chunjiang Wu, Min Wang, Qidong Tang, Rong Luo, Le Chen, Pengwu Zheng, Wufu Zhu   +6 more
doaj   +2 more sources

Use of Glucagon‐Like Peptide‐1 Receptor Agonists and Risk of Parkinson's Disease: Scandinavian Cohort Study [PDF]

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5767-5778, July 2026.
ABSTRACT Aims To investigate the association between use of GLP‐1 receptor agonists and incident Parkinson's disease. Material and Methods Cohort study using data from nationwide registers in Denmark, Norway and Sweden and an active‐comparator, new‐user design.
Arvid Engström, Henrik Svanström, Anders Hviid, Björn Eliasson, Soffia Gudbjörnsdottir, Viktor Wintzell, Kristian Hveem, Christian Jonasson, Mads Melbye, Peter Ueda, Björn Pasternak   +10 more
wiley   +2 more sources

Sulfonylurea Receptor 1 in Humans with Post-Traumatic Brain Contusions [PDF]

J Neurotrauma, 2015
Tamara Martínez-Valverde, M. Vidal-Jorge, E. Martínez-Sáez, Lidia Castro, F. Arikan, E. Cordero, A. Rădoi, M. Poca, J. Simard, J. Sahuquillo   +9 more
semanticscholar   +2 more sources

Overexpression of a Short Sulfonylurea Splice Variant Increases Cardiac Glucose Uptake and Uncouples Mitochondria by Regulating ROMK Activity

Life, 2023
The mitochondrial splice variant of the sulfonylurea receptor (SUR2A-55) is associated with protection from myocardial ischemia-reperfusion (IR) injury, increased mitochondrial ATP sensitive K+ channel activity (mitoKATP) and altered glucose metabolism ...
Sarah K. El-Meanawy, Holly Dooge, Allison C. Wexler, Anna C. Kosmach, Lara Serban, Elizabeth A. Santos, Francisco J. Alvarado, Timothy A. Hacker, Mohun Ramratnam   +8 more
doaj   +1 more source

Pharmacological Profiling of K_ATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine

Pharmaceuticals, 2023
Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring, Inger Jansen-Olesen, Palle Christophersen, Jes Olesen   +3 more
doaj   +1 more source

Transient neonatal diabetes mellitus caused by a gene mutation [PDF]

Korean Journal of Pediatrics, 2011
Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes mellitus that presents within the first 6 months of life with remission in infancy or early childhood.
Jung Hyun Kong, June Bum Kim
doaj   +1 more source