Results 1 to 10 of about 1,154,493 (312)
Frontiers in Pharmacology, 2023 Objective: PB-119, a PEGylated exenatide injection, is a once-weekly glucagon-like peptide-1 receptor agonist. In the present study, we aimed to evaluate the effects of PB-119 on insulin resistance and beta-cell function in Chinese patients with type 2 ...
Xu Liu +15 more
doaj +1 more source
WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice
Discover Oncology, 2023 Non-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated.
Wanting Xue +7 more
doaj +1 more source
Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease
Frontiers in Pharmacology, 2022 The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries ...
Yajie Fu +12 more
doaj +1 more source
Emerging Roles of Wnt Ligands in Human Colorectal Cancer
Frontiers in Oncology, 2020 Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases.
Xiaobo Nie +5 more
doaj +1 more source
Role of G-protein coupled receptors in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2023 Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li +4 more
doaj +1 more source
The Apelin/APJ System in Psychosis and Neuropathy
Frontiers in Pharmacology, 2020 Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals ...
Shuang-Yu Lv +3 more
doaj +1 more source
Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors [PDF]
, 2011 Subtype 2 serotonin (5-hydroxytryptamine, 5-HT) receptors are major drug targets for schizophrenia, feeding disorders, perception, depression, migraines, hypertension, anxiety, hallucinogens, and gastrointestinal dysfunctions.' We report here ...
Abrol, Ravinder +4 more
core +2 more sources
Frontiers in Pharmacology, 2019 The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC).
Xiaobo Nie +13 more
doaj +1 more source
Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core +1 more source
Emerging Roles of NPQ/Spexin in Physiology and Pathology
Frontiers in Pharmacology, 2019 Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide. Spexin gene and protein are widely expressed in central nervous system and peripheral tissues in humans, rodents, goldfish, etc.
Shuang-Yu Lv +5 more
doaj +1 more source