Results 21 to 30 of about 3,151,822 (315)

SYNERGISM AND DRUG-RECEPTOR

Japanese Journal of Pharmacology, 1964
In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
TAKAGI, KEIJIRO, TAKAYANAGI, ISSEI
openaire   +3 more sources

GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization

Frontiers in Molecular Neuroscience, 2019
Differential regulation of the μ-opioid receptor (MOP) has been linked to the development of opioid tolerance and dependence which both limit the clinical use of opioid analgesics.
Arisbel B. Gondin, Arisbel B. Gondin, Arisbel B. Gondin, Michelle L. Halls, Meritxell Canals, Meritxell Canals, Meritxell Canals, Stephen J. Briddon, Stephen J. Briddon   +8 more
doaj   +1 more source

Nuclear receptors: a bridge linking the gut microbiome and the host

Molecular Medicine, 2021
Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties
Zixuan Wang, Wei-Dong Chen, Yan-Dong Wang   +2 more
doaj   +1 more source

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

iScience, 2018
Summary: The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their ...
Diana C. Alcobia, Alexandra I. Ziegler, Alexander Kondrashov, Eleonora Comeo, Sarah Mistry, Barrie Kellam, Aeson Chang, Jeanette Woolard, Stephen J. Hill, Erica K. Sloan   +9 more
doaj   +1 more source

Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract [PDF]

, 2012
Background: G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate ...
Schiöth, Helgi B,, Olszewski, Pawel K, Cedernaes, Jonathan,, Vergoni, Anna V, Schiöth, Helgi B, Jonathan Cedernaes, Schiöth, Helgi B., Anna V Vergoni, Pawel K Olszewski, Badiali, Luca, Luca Badiali, Olof Nylander, Badiali, Luca,, Helgi B Schiöth, Nylander, Olof, Nylander, Olof,, VERGONI, Anna Valeria, Olszewski, Pawel K., Vergoni, Anna V., Cedernaes, Jonathan, Olszewski, Pawel K,, Nylander Olof, Badiali Luca, Vergoni Anna V, Schiöth Helgi B, Olszewski Pawel K, Cedernaes Jonathan   +26 more
core   +2 more sources

Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

Acta Pharmaceutica Sinica B, 2021
Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization. With no curative therapy for IBD at present, the development of effective therapeutics is highly advocated.
Peng Liu, Caifang Gao, Hongguo Chen, Chi Teng Vong, Xu Wu, Xudong Tang, Shengpeng Wang, Yitao Wang   +7 more
doaj   +1 more source

Ganfule capsule alleviates AFB1-induced toxic liver injury via inhibiting oxidative stress, inflammatory response, and apoptosis

Ecotoxicology and Environmental Safety
Aflatoxins, particularly aflatoxin B1 (AFB1), are widely present in the environment and pose a significant risk to food safety. However, no specific drugs are available for AFB1-induced toxic liver injury. Ganfule (GFL) is a traditional Chinese medicine (
Pan Li, Yujia Cao, Yifan Hou, Jianhua Zhang, Linlin Zhang, Ziang Li, Hongtao Xu, Wenbo Zhang, Zhenhua Zhao, Xiaobo Nie, Junqing Hou   +10 more
doaj   +1 more source

Structure-Function Analyses of Human Bitter Taste Receptors—Where Do We Stand?

Molecules, 2020
The finding that bitter taste receptors are expressed in numerous tissues outside the oral cavity and fulfill important roles in metabolic regulation, innate immunity and respiratory control, have made these receptors important targets for drug discovery.
Maik Behrens, Florian Ziegler
doaj   +1 more source

Pregnane Xenobiotic Receptors and Their Effect on Drug Elimination from the Organism

Prague Medical Report, 2013
Nuclear receptors are intracellular proteins which, having been activated by their more or less specific ligands, regulate (usually increase) the transcription of target genes.
Martin Šíma, I. Netíková, O. Slanař
doaj   +1 more source

Molecular Simulations and Drug Discovery of Adenosine Receptors

Molecules, 2022
G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins. Four subtypes of adenosine receptors (ARs), the A1AR, A2AAR, A2BAR and A3AR, each with a unique pharmacological profile and distribution within the tissues in ...
Jinan Wang, Apurba Bhattarai, Hung N. Do, Sana Akhter, Yinglong Miao   +4 more
doaj   +1 more source