Results 21 to 30 of about 725,377 (269)

Ganfule capsule alleviates AFB1-induced toxic liver injury via inhibiting oxidative stress, inflammatory response, and apoptosis

Ecotoxicology and Environmental Safety
Aflatoxins, particularly aflatoxin B1 (AFB1), are widely present in the environment and pose a significant risk to food safety. However, no specific drugs are available for AFB1-induced toxic liver injury. Ganfule (GFL) is a traditional Chinese medicine (
Pan Li, Yujia Cao, Yifan Hou, Jianhua Zhang, Linlin Zhang, Ziang Li, Hongtao Xu, Wenbo Zhang, Zhenhua Zhao, Xiaobo Nie, Junqing Hou   +10 more
doaj   +1 more source

Molecular Simulations and Drug Discovery of Adenosine Receptors

Molecules, 2022
G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins. Four subtypes of adenosine receptors (ARs), the A1AR, A2AAR, A2BAR and A3AR, each with a unique pharmacological profile and distribution within the tissues in ...
Jinan Wang, Apurba Bhattarai, Hung N. Do, Sana Akhter, Yinglong Miao   +4 more
doaj   +1 more source

Pregnane Xenobiotic Receptors and Their Effect on Drug Elimination from the Organism

Prague Medical Report, 2013
Nuclear receptors are intracellular proteins which, having been activated by their more or less specific ligands, regulate (usually increase) the transcription of target genes.
Martin Šíma, I. Netíková, O. Slanař
doaj   +1 more source

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?

Frontiers in Cellular Neuroscience, 2016
Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
doaj   +1 more source

Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery

iScience, 2020
Summary: Compared with conventional chemotherapy and radiotherapy, targeted molecular therapy, e.g., antibody-drug conjugates or aptamer-drug conjugates, can specifically identify overexpressed natural receptors on the cancer cell, perform targeted ...
Hoda Safari Yazd, Yu Yang, Long Li, Lu Yang, Xiaowei Li, Xiaoshu Pan, Zhuo Chen, Jianhui Jiang, Cheng Cui, Weihong Tan   +9 more
doaj   +1 more source

G protein-coupled receptors: structure- and function-based drug discovery

Signal Transduction and Targeted Therapy, 2021
As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.
Dehua Yang, Qingtong Zhou, Viktorija Labroska, Shanshan Qin, Sanaz Darbalaei, Yiran Wu, Elita Yuliantie, Linshan Xie, Houchao Tao, Jianjun Cheng, Qing Liu, Suwen Zhao, Wenqing Shui, Yi Jiang, Ming-Wei Wang   +14 more
doaj   +1 more source

Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies

Molecules, 2021
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets.
Yann Waltenspühl, Janosch Ehrenmann, Christoph Klenk, Andreas Plückthun   +3 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The drug-receptor complex

Journal of Pharmacy and Pharmacology, 1966
Abstract The rate of association of drug and receptor when limited by diffusion alone will correspond to a basic rate of 2·5 × 109 litres/mole sec and will have a net activation energy of 3–4 kcal/mole. This rate will not be significantly increased by attractive forces between drug and receptor but could be reduced by repulsive forces ...
openaire   +2 more sources

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source