Results 31 to 40 of about 3,151,822 (315)
Adenosine receptors as targets for drug development
, 2003 Adenosine is a ubiquitous autacoid that acts on four defined receptors, named A(1), A(2A), A(2B) and A(3). Although the biological activity of adenosine has been known for more than 70 years and the existence of specific receptors for more than 25 years,
B.B. Fredholm, Fredholm, BB
core +1 more source
Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
Frontiers in Cellular Neuroscience, 2016 Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
doaj +1 more source
iScience, 2020 Summary: Compared with conventional chemotherapy and radiotherapy, targeted molecular therapy, e.g., antibody-drug conjugates or aptamer-drug conjugates, can specifically identify overexpressed natural receptors on the cancer cell, perform targeted ...
Hoda Safari Yazd +9 more
doaj +1 more source
Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis [PDF]
, 2003 Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging contrast agents or in drug delivery applications.
Berry, C.C. +3 more
core +1 more source
Molecules, 2021 Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets.
Yann Waltenspühl +3 more
doaj +1 more source
Journal of Pharmacy and Pharmacology, 1966 Abstract The rate of association of drug and receptor when limited by diffusion alone will correspond to a basic rate of 2·5 × 109 litres/mole sec and will have a net activation energy of 3–4 kcal/mole. This rate will not be significantly increased by attractive forces between drug and receptor but could be reduced by repulsive forces ...
openaire +2 more sources
The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]
, 2014 This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core
Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine +17 more
wiley +1 more source
G protein-coupled receptors: structure- and function-based drug discovery
Signal Transduction and Targeted Therapy, 2021 As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.
Dehua Yang +14 more
doaj +1 more source
Nicotine addiction : a review [PDF]
, 2013 Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core +1 more source