Results 11 to 20 of about 2,998,144 (312)
Mixed-model QSAR at the glucocorticoid and liver X receptors [PDF]
, 2009 The presence of hormonally active compounds in the biosphere has become a worldwide environmental concern, and measures such as policy acts and regulations try to address the problem, both in Europe and in the United States.
Spreafico, Morena
core +1 more source
eLife, 2020 By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R ...
J Robert Lane +10 more
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Opioids and Their Receptors [PDF]
, 2020 The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of ...
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Drug‐resistant epilepsy: Drug target hypothesis and beyond the receptors
Epilepsia Open, 2022 Epilepsy is a chronic neurological disorder that affects more than 50 million people worldwide. Despite a recent introduction of antiseizure drugs for the treatment of epileptic seizures, one‐third of these patients suffer from drug‐resistant epilepsy ...
Daniel Fonseca‐Barriendos +5 more
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On the hierarchical classification of G Protein-Coupled Receptors [PDF]
, 2007 Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
Matthew N. Davies +11 more
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Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma
Frontiers in Pharmacology, 2018 Hepatocellular carcinoma is one of the leading causes of cancer death worldwide and the activation of canonical Wnt signaling pathway is universal in hepatocellular carcinoma patients.
Xiaobo Nie +5 more
doaj +1 more source
Japanese Journal of Pharmacology, 1964 In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
TAKAGI, KEIJIRO, TAKAYANAGI, ISSEI
openaire +3 more sources
Xenobiotic receptors in mediating the effect of sepsis on drug metabolism
Acta Pharmaceutica Sinica B, 2020 Sepsis is an infection-induced systemic inflammatory syndrome. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways.
Chuanzhu Lv, Ling Huang
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Nuclear receptors: a bridge linking the gut microbiome and the host
Molecular Medicine, 2021 Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties
Zixuan Wang +2 more
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PET Imaging Radiotracers of Chemokine Receptors
Molecules, 2021 Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells.
Santosh R. Alluri +2 more
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