Results 31 to 40 of about 1,253,570 (258)

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

eLife, 2019
ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis.
Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng   +7 more
doaj   +1 more source

Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit

Molecules, 2015
Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by 1H-NMR, 13C-NMR, MS spectrum and elemental analysis.
Chunjiang Wu, Min Wang, Qidong Tang, Rong Luo, Le Chen, Pengwu Zheng, Wufu Zhu   +6 more
doaj   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen, Wied, Susanne, Pünter, Jürgen, Unkelbach, Angelika, Crecelius, Anna, Müller, Günter   +5 more
core   +1 more source

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide [PDF]

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
core   +1 more source

The unusual stoichiometry of ADP activation of the KATP channel

Frontiers in Physiology, 2014
KATP channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR.
Eric eHosy, Michel eVivaudou
doaj   +1 more source

Neonatal diabetes caused by the heterozygous Pro1198Leu mutation in the ABCC8 gene in a male infant: 6‐year clinical course

Journal of Diabetes Investigation, 2020
Neonatal diabetes is a rare disease, often caused by a monogenic abnormality. A male infant patient developed diabetic ketoacidosis at 2 months‐of‐age due to the heterozygous ABCC8 gene mutation (p.Pro1198Leu).
Shinsuke Uraki, Hiroto Furuta, Masakazu Miyawaki, Norihiko Matsutani, Yuko Shima, Miki Iwamoto, Shohei Matsuno, Shuhei Morita, Machi Furuta, Asako Doi, Hiroshi Iwakura, Hiroyuki Ariyasu, Masahiro Nishi, Hiroyuki Suzuki, Takashi Akamizu   +14 more
doaj   +1 more source

Determination of the molecular mass of the native beta-cell sulfonylurea receptor. [PDF]

, 1994
In the present study we have determined the molecular mass of the beta-cell sulfonylurea receptor in its native form by two different experimental approaches; gel filtration chromatography and radiation inactivation analysis.
Ashcroft, SJ, Skeer, JM, Potier, Michel, Pilar Dégano, Frances M. Ashcroft, Ashcroft, Frances, Stephen J.H. Ashcroft, Potier, M, Michel Potier, Ashcroft, FM, Coles, B, Ashcroft, Stephen J.H., Skeer, Jacqueline M., Barbara Coles, Dégano, P, Dégano, Pilar, Jacqueline M. Skeer, Coles, Barbara, Ashcroft, Frances M.   +18 more
core   +1 more source

Treatment of type 2 diabetes: the stability of the effectiveness of hypoglycemic medications

Ожирение и метаболизм, 2016
This article is dedicated to the problem of glycaemic durability of drugs used in treatment of type 2 diabetes. The results of studies comparing durability of glycemic control as monotherapy or in combination of metformin with different drugs: dipeptidyl
Tat'yana Morgunova, Valentin Fadeev
doaj   +1 more source

Swiss recommendations of the Society for Endocrinology and Diabetes (SGED/SSED) for the treatment of type 2 diabetes mellitus (2023)

Swiss Medical Weekly, 2023
As a first step, the authors emphasise lifestyle changes (increased physical activity, stopping smoking), blood pressure control, and lowering cholesterol).
Giacomo Gastaldi, Barbara Lucchini, Sebastien Thalmann, Stephanie Alder, Markus Laimer, Michael Brändle, Peter Wiesli, Roger Lehmann, Working group of the SGED/SSED   +8 more
doaj   +1 more source

Sulfonylurea is associated with higher risks of ventricular arrhythmia or sudden cardiac death compared with metformin: A population-based cohort study [PDF]

, 2022
Background Commonly prescribed diabetic medications such as metformin and sulfonylurea may be associated with different arrhythmogenic risks. This study compared the risk of ventricular arrhythmia or sudden cardiac death between metformin and ...
Jeremy Man Ho Hui, Danish Iltaf Satti, Tong Liu, Shuk Han Cheng, Pias Tang Hoi Kiu, Ian Chi Kei Wong, Wing Tak Wong, Teddy Tai Loy Lee, Yan Hiu Athena Lee, Bernard Man Yung Cheung, Gary Tse, Yuki Ka Ling Shum, Jeffrey Shi Kai Chan, Abraham Ka Chung Wai   +13 more
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