Results 31 to 40 of about 2,674,072 (303)

The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis

Frontiers in Endocrinology, 2022
AimsThis study aimed to assess the impact of different antidiabetic agents on individuals with diabetes and COVID-19.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to October 31, 2021 and included seven ...
Yidan Chen, Xingfei Lv, Sang Lin, Mohammad Arshad, Mengjun Dai   +4 more
doaj   +1 more source

Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation.

American Journal of Physiology. Heart and Circulatory Physiology, 2010
Sulfonylurea receptor-containing ATP-sensitive potassium (KATP) channels have been implicated in cardioprotection, but the cell type and constitution of channels responsible for this protection have not been clear.
D. Stoller, J. Fahrenbach, K. Chalupský, Bi-Hua Tan, Nitin T. Aggarwal, J. Metcalfe, Michele Hadhazy, N. Shi, J. Makielski, E. McNally   +9 more
semanticscholar   +2 more sources

From ions to insulin

eLife, 2017
Electron cryo-microscopy has revealed the three-dimensional structure of a potassium channel that has a central role in regulating the release of insulin from the pancreas.
Voula Kanelis
doaj   +1 more source

Transmembrane Topology of the Sulfonylurea Receptor SUR1 [PDF]

Journal of Biological Chemistry, 2001
Sulfonylurea receptors (SURx) are multi-spanning transmembrane proteins of the ATP-binding cassette (ABC) family, which associate with Kir6.x to form ATP-sensitive potassium channels. Two models, with 13-17 transmembrane segments, have been proposed for SURx topologies.
L R, Conti, C M, Radeke, S L, Shyng, C A, Vandenberg   +3 more
openaire   +2 more sources

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

eLife, 2017
KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas.
Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng   +7 more
doaj   +1 more source

Five‐year follow‐up of incretin‐based therapy in a patient with KCNJ11‐related permanent neonatal diabetes: Achieving insulin discontinuation and sulfonylurea reduction [PDF]

Journal of Diabetes Investigation, Volume 17, Issue 6, Page 1075-1078, June 2026.
In a woman with KCNJ11‐related permanent neonatal diabetes mellitus, incretin‐based therapy enabled insulin discontinuation and maintained glycemic control for more than 5 years, with HbA1c between 6.1% and 6.5% on the lowest semaglutide dose, dose‐dependent improvement in insulin secretion, and an approximately 60% reduction in glibenclamide dose ...
Toshiaki Ohkuma, Ryoichiro Aotani, Wakako Sakamoto, Ayaka Oshiro, Tetsuro Ago   +4 more
wiley   +2 more sources

Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones [PDF]

Diabetes & Metabolism Journal, 2011
BackgroundSulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ ...
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park   +5 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Anthelminthic activity of glibenclamide on secondary cystic echinococcosis in mice. [PDF]

PLoS Neglected Tropical Diseases, 2017
Cystic echinococcosis (CE) is a worldwide parasitic zoonosis caused by the larval stage of Echinococcus granulosus. Current chemotherapy against this disease is based on the administration of benzimidazoles (BZMs).
Julia A Loos, María Sandra Churio, Andrea C Cumino   +2 more
doaj   +1 more source

Glibenclamide Targets Sulfonylurea Receptor 1 to Inhibit p70S6K Activity and Upregulate KLF4 Expression to Suppress Non-Small Cell Lung Carcinoma

Molecular Cancer Therapeutics, 2019
Sulfonylurea receptor 1 (SUR1) is the regulatory subunit of ATP-sensitive potassium channels (KATP channels) and the receptor of antidiabetic drugs, such as glibenclamide, which induce insulin secretion in pancreatic β cells.
Kexin Xu, Geng Sun, Min Li, Hongling Chen, Zuhao Zhang, Xixi Qian, Ping Li, Lin Xu, Wenbin Huang, Xuerong Wang   +9 more
semanticscholar   +1 more source