Results 51 to 60 of about 2,674,072 (303)

Characterization of the rat mesangial cell type 2 sulfonylurea receptor

, 1999
Characterization of the rat mesangial cell type 2 sulfonylurea receptor.BackgroundSulfonylurea receptors are classified as either high-affinity type 1 (SUR1) or low-affinity type 2 receptors (SUR2), and the gene expression of SURs has recently been ...
Garvin, Jeffrey L, Garvin, Jeffrey L., Rodríguez-Barbero, Alicia, Riser, Bruce L, Cortes, Pedro, Riser, Bruce L., Szamosfalvi, Balázs, Asano, Kenichiro, Yee, Jerry   +8 more
core   +1 more source

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
core   +1 more source

The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel

Cell Reports, 2019
Summary: Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive potassium channel (KATP).
Dian Ding, Mengmeng Wang, Jing-Xiang Wu, Yunlu Kang, Lei Chen   +4 more
doaj   +1 more source

Identification of the Potassium Channel Opener Site on Sulfonylurea Receptors [PDF]

Journal of Biological Chemistry, 1999
Diversity of sulfonylurea receptor (SUR) subunits underlies tissue specific pharmacology of K(ATP) channels, which represent critical regulators of electrical activity in numerous cells. Notably, the neuronal/pancreatic beta-cell receptor, SUR1, imparts high sensitivity to hypoglycemic sulfonylureas (SUs; e.g.
I, Uhde, A, Toman, I, Gross, C, Schwanstecher, M, Schwanstecher   +4 more
openaire   +2 more sources

The Sulfonylurea Receptor 1 (Sur1)-Transient Receptor Potential Melastatin 4 (Trpm4) Channel

Journal of Biological Chemistry, 2012
Background: Sur1-NCCa-ATP channels implicated in acute CNS injury are hypothesized to be formed by co-association of Sur1 and a nonselective cation channel.
S. K. Woo, M. S. Kwon, A. Ivanov, V. Gerzanich, J. Simard   +4 more
semanticscholar   +1 more source

Optimization of therapy of type 2 diabetes mellitus with the oral hypoglycemic agent glimepiride

Сахарный диабет, 2010
Type 2 diabetes is believed to develop as a result of lowered insulin secretion and insulin resistance leading to hyperglycemia. Sulfonylureas stimulateinsulin secretion and thereby decrease blood glucose level which accounts for their wide application ...
Tatiana Ivanovna Romantsova, Nadezhda Viktorovna Maksimova   +1 more
doaj   +1 more source

Refractory Hypoglycaemia- The Need for Genetic Work Up [PDF]

Indian Journal of Neonatal Medicine and Research, 2020
Congenital Hyperinsulinism of Infancy (CHI) is a rare condition that causes of persistent hypoglycemia refractory to treatment. Neonatal hypoglycaemia is caused by numerous clinical conditions, such as birth asphyxia, Small for Gestation Age (SGA ...
Charu Jha, Bhavesh Rathod
doaj   +1 more source

Sulfonylurea receptor 1 in central nervous system injury: a focused review

Journal of Cerebral Blood Flow and Metabolism, 2012
The sulfonylurea receptor 1 (Sur1)-regulated NCCa-ATP channel is a nonselective cation channel that is regulated by intracellular calcium and adenosine triphosphate.
J. Simard, S. K. Woo, G. Schwartzbauer, V. Gerzanich   +3 more
semanticscholar   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

National ambulatory care non-insulin antidiabetic medication prescribing trends in the United States from 2009 to 2015.

PLoS ONE, 2019
ObjectiveDespite their efficacy in lowering hemoglobin A1c, recent data suggest that sulfonylureas are associated with cardiovascular risk and hypoglycemia.
Amanda K Kitten, Meghan Kamath, Laurajo Ryan, Kelly R Reveles   +3 more
doaj   +1 more source